Clinical manifestations of elderly patients with digitalis intoxication in the emergency department

Archives of Gerontology and Geriatrics

Volumn 53, Issue 2, 2011, Pages

  Pita Fernández, Salvador ^a   Lombardía Cortiña, Mónica ^a   Orozco Veltran, Domingo ^b   Gil Guillén, Vicente ^b  

^a HOSPITAL JUAN CANALEJO   (Spain)

^b MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

Author keywords

Adverse effects of digitalis; Diagnosis of digitalis intoxication; Digitalis treatment; Intoxication by digitalis; Toxicity of digitalis

Indexed keywords

AMIODARONE; CALCIUM ION; CLARITHROMYCIN; CREATININE; DIGOXIN; DIGOXIN ANTIBODY; ERYTHROMYCIN; OMEPRAZOLE; PHOSPHORUS; POTASSIUM ION; SODIUM ION; SPIRONOLACTONE;

AGED; ANOREXIA; ARTICLE; BRADYCARDIA; CLINICAL ARTICLE; CLINICAL FEATURE; CREATININE CLEARANCE; DIGITALIS INTOXICATION; DIGOXIN BLOOD LEVEL; DISEASE SEVERITY; DRUG ABSORPTION; DRUG ANTAGONISM; DRUG INDICATION; ELECTROCARDIOGRAM; EMERGENCY WARD; FATIGUE; FEMALE; FUNCTIONAL STATUS; GLOMERULOPATHY; GLOMERULUS FILTRATION RATE; HEART EJECTION FRACTION; HEART FAILURE; HEART FIBRILLATION; HUMAN; HYPERTENSION; ISCHEMIC CARDIOMYOPATHY; KIDNEY CLEARANCE; MALE; NAUSEA; PRIORITY JOURNAL; SPAIN; SYMPTOMATOLOGY; UNIVERSITY HOSPITAL; VALVULAR HEART DISEASE; VOMITING;

AGED; AGED, 80 AND OVER; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIAS, CARDIAC; BRADYCARDIA; DIGITALIS; DIGITALIS GLYCOSIDES; DIGOXIN; ELECTROCARDIOGRAPHY; EMERGENCY SERVICE, HOSPITAL; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; MALE; PROGNOSIS; RETROSPECTIVE STUDIES;

EID: 79960107679     PISSN: 01674943     EISSN: 18726976     Source Type: Journal    
DOI: 10.1016/j.archger.2010.07.003     Document Type: Article

References (24)

1. Aarnoudse A.L., Dieleman J.P., Stricker B.H. Age- and gender-specific incidence of hospitalisation for digoxin intoxication. Drug Safety 2007, 30:431-436.
2. Antman E.M., Wenger T.L., Butler, Haber E., Smith T.W. Treatment of 150 cases of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments. Final report of a multicenter study. Circulation 1990, 81:1744-1752.
3. Beller G.A., Smith T.W., Abelmann W.H., Haber E., Hood Digitalis intoxication. A prospective clinical study with serum level correlations. N. Engl. J. Med. 1971, 284:989-997.
4. Bonilla-Porras M., Lucena Campillo M.A., Delgado Silveira E., Ramallal Jiménez Del Llano M.C., García Díaz B. Intoxicacion digitalica secundaria al tratamiento con claritromicina. Farm. Hosp. 2005, 29:209-213. (in Spanish).
5. Cusack B., Kelly J., O'Malley K., Noel J., Lavan J., Horgan J. Digoxin in the elderly: pharmacokinetic consequences of old age. Clin. Pharmacol. Ther. 1979, 25:772-776.
6. Delk C., Holstege C.P., Brady W.J. Electrocardiographic abnormalities associated with poisoning. Am. J. Emerg. Med. 2007, 25:672-687.
7. Hanratty C.G., McGlinchey P., Johnston G.D., Passmore A.P. Differential pharmacokinetics of digoxin in elderly patients. Drugs Aging 2000, 17:353-362.
8. Haynes K., Heitjan D., Kanetsky P., Hennessy S. Declining public health burden of digoxin toxicity from 1991 to 2004. Clin. Pharmacol. Ther. 2008, 84:90-94.
9. Heinrich K., Prendergast H.M., Erickson T. Chronic digoxin toxicity and significantly elevated BNP levels in the presence of mild heart failure. Am. J. Emerg. Med. 2005, 23:561-562.
10. Honrubia A., Andrés J.M., Alcaine F., Bonasa E., Fernández J., Luján B. Alteraciones visuales inducidas por digoxina con niveles terapeuticos. Arch. Soc. Esp. Oftalmol. 2000, 75:55-56. (in Spanish).
11. Hornestam B., Jerling M., Karlsson M.O., Held P. Intravenously administered digoxin in patients with acute atrial fibrillation: a population pharmacokinetic/pharmacodynamic analysis based on the digitalis in acute atrial fibrillation trial. Eur. J. Clin. Pharmacol. 2003, 58:747-755. DAAF Trial Group.
12. Kiley C.A., Cragin D.J., Roth B.J. Omeprazole-associated digoxin toxicity. South Med. J. 2007, 100:400-402.
13. Klein-Schwartz W., Oderda G.M. Poisoning in the elderly epidemiological, clinical and management considerations. Drugs Aging 1991, 1:67-89.
14. Ma G., Brady W.J., Pollack M., Chan T.C. Electrocardiographic manifestations: digitalis toxicity. J. Emerg. Med. 2001, 20:145-152.
15. Mahajan N., Mahboobi S., Mopala P., Lichstein E., Thekkoott D. Digoxin toxicity in renal failure: role of the electrocardiogram. Br. J. Hosp. Med. (Lond) 2007, 68:216-217.
16. Mangoni A.A., Jackson S.H. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br. J. Clin. Pharmacol. 2004, 57:6-14.
17. Matzke G.R., Frye R.F. Drug administration in patients with renal insufficiency minimising renal and extrarenal toxicity. Drug Safety 1997, 16:205-231.
18. Medina-González L., Fuentes Ferrer M.E., Suárez Llanos J.P., Arranz Peña M.I., Ochoa Mangado E. Epidemiologia de las intoxicaciones medica-mentosas durante un año en el Hospital Universitario Ramon y Cajal. Rev. Clin. Esp. 2008, 9:432-436. (in Spanish).
19. Miura T., Kojima R., Sugiura Y., Mizutani M., Takatsu F., Suzuki Y. Effect of aging on the incidence of digoxin toxicity. Ann. Pharmacother. 2000, 34:427-432.
20. Munidasa U.A., Gawarammana I.B., Kularatne S.A., Kumarasiri P.V., Goonasekera C.D. Survival pattern in patients with acute organophosphate poisoning receiving intensive care. J. Toxicol. Clin. Toxicol. 2004, 42:343-347.
21. Oishi A., Miyamoto K., Kashii S., Yoshimura N. Photopsia as a manifestation of digitalis toxicity. Can. J. Ophthalmol. 2006, 41:603-604.
22. Rich M.W. Epidemiology, pathophysiology, and etiology of congestive heart failure in older adults. J. Am. Geriatr. Soc. 1997, 45:968-974.
23. Rodríguez-Calvo M.S., Rico R., López-Rivadulla M., Suárez-Peñaranda J.M., Muñoz J.I., Concheiro L. Report of a suicidal digoxin intoxication: a case report. Med. Sci. Law 2002, 42:265-268.
24. Wofford J.L., Ettinger W.H. Risk factors and manifestations of digoxin toxicity in the elderly. Am. J. Emerg. Med. 1991, 9(Suppl. 1):11-15.