The HIV/AIDS epidemic in sub-Saharan Africa: Thinking ahead on programmatic tasks and related operational research

Journal of the International AIDS Society

Volumn 14, Issue SUPPL. 1, 2011, Pages

  Zachariah, Rony ^a   Van Damme, Wim ^b   Arendt, Vic ^c   Schmit, Jean Claude ^c   Harries, Anthony D ^d,e  

^a MÉDECINS SANS FRONTIÈRES   (Switzerland)

^b INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^c Public Centre for Health Research and Central Hospital   (Luxembourg)

^d INTERNATIONAL UNION AGAINST TUBERCULOSIS AND LUNG DISEASE   (France)

^e LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AFRICA SOUTH OF THE SAHARA; ARTICLE; CD4 LYMPHOCYTE COUNT; COST EFFECTIVENESS ANALYSIS; DEVELOPING COUNTRY; DISEASE SURVEILLANCE; DISEASE TRANSMISSION; EPIDEMIC; FUNDING; HEALTH CARE COST; HEALTH CARE DELIVERY; HEALTH CARE POLICY; HEALTH EDUCATION; HEALTH PROGRAM; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNIZATION; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; INFECTION CONTROL; INFECTION PREVENTION; PRIORITY JOURNAL; RISK ASSESSMENT; RISK REDUCTION; SYSTEM ANALYSIS; TUBERCULOSIS; ECONOMICS; PUBLIC HEALTH;

ACQUIRED IMMUNODEFICIENCY SYNDROME; AFRICA SOUTH OF THE SAHARA; ANTI-HIV AGENTS; COMMUNICABLE DISEASE CONTROL; HIV INFECTIONS; HUMANS; NATIONAL HEALTH PROGRAMS; OPERATIONS RESEARCH;

EID: 79960099288     PISSN: None     EISSN: 17582652     Source Type: Journal    
DOI: 10.1186/1758-2652-14-S1-S7     Document Type: Article

References (67)

1. UNAIDS report on the global AIDS epidemic 2010. UNAIDS, UNAIDS/10.11E/ JC1958E 2010 http://www.unaids.org/ documents/20101123-GlobalReport-em.pdf
2. Towards Universal Access;: scaling up priority HIV/AIDS interventions in the health sector. WHO, 2010 http://www.who.int/hiv/pub/2009progressreport/en/ index.html
3. The 3 by 5 Initiative. Treat three million people with HIV/AIDS by 2005. WHO, 2002 http://www.who.int/3by5/en/
4. Millennium Development Goals. Traget 6. United Nations, 2000 http://www.un.org/millenniumgoals/aids.shtml
5. Getting to Zero. 2011-2015 strategy. UNAIDS, 2011 http://www.unaids.org/ en/media/unaids/contentassets/documents/unaidspublication/2010/ JC2034-UNAIDS-Strategy-en.pdf
6. Operational research in low-income countries: what, why, and how? R Zachariah AD Harries N Ishikawa HL Rieder K Bissell K Laserson M Massaquoi M Van Herp T Reid, Lancet Infect Dis 2009 9 11 711 717 10.1016/S1473-3099(09)70229-4 19850229
7. Taking long term-view. UNAIDS, 2010 http://www.ftpress.com/store/product. aspx?isbn=0132614146
8. Treatment 2.0. Is this the future of treatment? UNAIDS, 2009 http://data.unaids.org/pub/Outlook/2010/20100713-outlook-treatment2-0-en.pdf
9. Male circumcision for the prevention of heterosexually acquired HIV infection: a meta-analysis of randomized trials involving 11,050 men. E Mills C Cooper A Anema G Guyatt, HIV Med 2008 9 6 332 335 10.1111/j.1468-1293.2008. 00596.x 18705758 (Pubitemid 352015640)
10. Risk compensation is not associated with male circumcision in Kisumu, Kenya: a multi-faceted assessment of men enrolled in a randomized controlled trial. CL Mattson RT Campbell RC Bailey K Agot JO Ndinya-Achola S Moses, PLoS One 2008 3 6 e2443
11. Male circumcision for HIV prevention. WHO, 2007 http://www.who.int/hiv/ topics/malecircumcision/en/index.html
12. Towards Universal Access. Scaling up priority HIV/AIDS interventions in the health sector. WHO UNAIDS UNICEF, Progress report 2010 http://www.who.int/ hiv/pub/2010progressreport/summary-en.pdf
13. Male circumcision for HIV prevention: current research and programmatic issues. HA Weiss KE Dickson K Agot CA Hankins, AIDS 2010 24 Suppl 4 61 69 10.1097/01.aids.0000390708.66136.f4 21042054
14. HIV/AIDS and circumcision: lost in translation. M Fox M Thomson, J Med Ethics 2010 36 12 798 801 10.1136/jme.2010.038695 21112939
15. Antiretroviral drugs for treating pregnant women and preventing HIV infection in infants. WHO, 2009 http://www.who.int/hiv/pub/mtct/ antiretroviral2010/en/index.html
16. (Womens HIV Prevention Tracking Project). Making Medical Male Circumcision Work for Women. WHiPT, 2010 http://www.avac.org/ht/a/ GetDocumentAction/i/28715
17. HIV/AIDS Progress Under Siege Double Blow of Reduced Funding and High Drug Prices Blocks Impact of Latest Science and Treatment Recommendations for People Living With HIV/AIDS. MSF, 2010 http://www.doctorswithoutborders.com/ oublications/article.cfm?id=489O&cat=special-report
18. Global HIV/AIDS funding and health systems: Searching for the win-win. R Levine N Oomman, J Acquir Immune Defic Syndr 2009 52 Suppl 1 3 5 19858934
19. Health systems exist for real people. WM El-Sadr KM De Cock, J Acquir Immune Defic Syndr 2009 52 Suppl 1 1 2 19953690
20. The role of nonphysician clinicians in the rapid expansion of HIV care in Mozambique. K Sherr J Pfeiffer A Mussa F Vio S Gimbel M Micek S Gloyd, J Acquit Immune Defic Syndr 2009 52 Suppl 1 20 23
21. A national survey of the impact of rapid scale-up of antiretroviral therapy on health-care workers in Malawi: effects on human resources and survival. SD Makombe A Jahn H Tweya S Chuka JK Yu M Hochgesang J Aberle-Grasse O Pasulani EJ Schouten K Kamoto AD Harries, Bull World Health Organ 2007 85 851 857 18038075 (Pubitemid 350086457)
22. Mortality reduction associated with HIV/AIDS care and antiretroviral treatment in rural Malawi: evidence from registers, coffin sales and funerals. B Mwagomba R Zachariah M Massaguoi D Misindi M Manzi BC Mandere M Bemelmans M Philips K Kamoto EJ Schouten AD Harries, PLoS One 2010 5 5 10452 10.1371/journal.pone.0010452 20454611
23. Effect of highly active antiretroviral therapy on incidence of tuberculosis in South Africa: a cohort study. M Badri D Wilson R Wood, Lancet 2002 359 2059 2064 10.1016/S0140-6736(02)08904-3 12086758 (Pubitemid 34680968)
24. Antiretroviral therapy for control of the HIV-associated MDR and XDR tuberculosis epidemic in South Africa. SD Lawn R Wood, Am J Respir Crit Care Med 2010 182 1567 author reply 8-9 21159908
25. Tuberculosis among HIV-infected patients receiving HAART: long term incidence and risk factors in a South African cohort. SD Lawn M Badri R Wood, AIDS 2005 19 2109 2116 10.1097/01.aids.0000194808.20035.c1 16284460 (Pubitemid 41668999)
26. Low prevalence of Plasmodium falciparum antigenaemia among asymptomatic HAART-treated adults in an urban cohort in Uganda. D Nakanjako AN Kiragga B Castelnuovo DJ Kyabayinze MR Kamya, Malar J 2011 10 66 10.1186/1475-2875-10-66 21426579
27. Effect of co-trimoxazole prophylaxis, antiretroviral therapy, and insecticide-treated bednets on the frequency of malaria in HIV-1-infected adults in Uganda: a prospective cohort study. J Mermin JP Ekwaru CA Liechty W Were R Downing R Ransom P Weidle J Lule A Coutinho P Solberg, Lancet 2006 367 1256 1261 10.1016/S0140-6736(06)68541-3 16631881
28. Impact of HIV treatment scale-up on women's reproductive health care and reproductive rights in Southern Africa. L Myer P Akugizibwe, J Acquir Immune Defic Syndr 2009 52 Suppl 1 52 53 19858940
29. Strategies to improve patient retention on antiretroviral therapy in sub-Saharan Africa. AD Harries R Zachariah SD Lawn S Rosen, Trop Med Int Health 2010 52 Suppl 1 70 75
30. Health services strengthening in Africa-research is a key component. S Jaffar JV Lazarus P Onyebujoh J Chakaya A Garrib P Mwaba S Mboup K Bellis S Egwaga T Corrah A Coutinho, Trop Med Int Health 2010 15 1270 1273 10.1111/j.1365-3156.2010.02626.x 20731794
31. Inequities in the global health workforce: the greatest impediment to health in sub-Saharan Africa. SC Anyangwe C Mtonga, Int J Environ Res Public Health 2007 4 2 93 100 10.3390/ijerph2007040002 17617671 (Pubitemid 47026512)
32. Scaling-up antiretroviral treatment in Southern African countries with human resource shortage: how will health systems adapt? W Van Damme K Kober G Kegels, Soc Sci Med 2008 66 10 2108 2121 10.1016/j.socscimed.2008.01.043 18329774 (Pubitemid 351509687)
33. How labour intensive is a doctor-based delivery model for antiretroviral treatment (ART)? Evidence from an observational study in Siem Reap, Cambodia. W Van Damme ST Kheang B Janssens K Kober, Hum Resour Health 2007 5 12 10.1186/1478-4491-5-12 17470304
34. Hunger, waiting time and transport costs: time to confront challenges to ART adherence in Africa. AP Hardon D Akurut C Comoro C Ekezie HF Irunde T Gerrits J Kglatwane J Kinsman R Kwasa J Maridadi TM Moroka S Moyo A Nakiyemba S Nsimba R Ogenyi T Oyabba F Temu R Laing, AIDS Care 2007 19 658 665 10.1080/09540120701244943 17505927 (Pubitemid 46763738)
35. A model for extending antiretroviral care beyond the rural health centre. KK Wools-Kaloustian JE Sidle HM Selke R Vedanthan EK Kemboi LJ Boit VT Jebet AE Carroll WM Tierney S Kimaiyo, J Int AIDS Soc 2009 12 1 22 10.1186/1758-2652-12- 22 19788755
36. Rates of virological failure in patients treated in a home-based versus a facility-based HIV-care model in Jinja, southeast Uganda: a cluster-randomised equivalence trial. S Jaffar B Amuron S Fosters J Birungi J Levin G Namara C Nabiryo M Ndembi R Kyomuhangi A Opio R Bunnell JW Tappero J Mermin A Coutinho H Grosskurth, Lancet 2009 374 9707 2080 2089 19939445
37. Distribution of antiretroviral treatment through self-forming groups of patients in Tete province, Mozambique. T Decroo B Telfer M Biot J Maikere S Dezembro LI Cumba CD Dores K Chu N Ford, J Acquir Immune Defic Syndr 2010
38. Why do we need a point-of-care CD4 test for low-income countries? R Zachariah SD Reid P Chaillet M Massaguoi EJ Schouten AD Harries, Trop Med Int Health 2011 16 37 41 10.1111/j.1365-3156.2010.02669.x 21371207
39. Task shifting in HIV/AIDS: opportunities, challenges and proposed actions for sub-Saharan Africa. R Zachariah N Ford M Philips S Lynch M Massaguoi V Janssens AD Harries, Trans R Soc Trop Med Hyg 2009 103 6 549 558 10.1016/j.trstmh.2008.09.019 18992905
40. Community involvement in HIV and tuberculosis research. M Harrington, J Acquir Immune Defic Syndr 2009 52 Suppl 1 63 66 19858944
41. Antiretroviral therapy for HIV infection in adults and adolescents: Recommendations for a public health approach. WHO, 2010 http://www.who.int/hiv/ pub/arv/adult2010/en/index.htm
42. Early versus standard antiretroviral therapy for HIV-infected adults in Haiti. P Severe MA Juste A Ambroise L Eliacin C Marchand S Apollon A Edwards H Bang J Nicotera C Godfrey RM Gulick WD Johnson Jr JW Pape DW Fitzgeralc, N Eng J Med 2010 363 3 257 265 10.1056/NEJMoa0910370
43. Early initiation of antiretroviral therapy and associated reduction in mortality, morbidity and defaulting in a nurse-managed, community cohort in Lesotho. N Ford K Kranzer K Hilderbrand G Jouquet E Goemaere N Vlahakis L Trivino L Makakole H Bygrave, AIDS 2010 24 17 2645 2650 10.1097/QAD. 0b013e32833ec5b2 20980868
44. Unacceptable attrition among WHO stages 1 and 2 patients in a hospital-based setting in rural Malawi: can we retain such patients within the general health system? K Tayler-Smith R Zachariah M Massaquoi M Manzi O Pasulani T van den Akker M Bemelmans A Bauernfeind B Mwagomba AD Harries, Trans R Soc Trop Med Hyg 2010 104 5 313 319 10.1016/j.trstmh.2010.01.007 20138323
45. "Talkin' about a revolution": How electronic health records can facilitate the scale-up of HIV care and treatment and catalyze primary care in resource-constrained settings. P Braitstein RM Einterz JE Sidle S Kimaiyo W Tierney, J Acquir Immune Defic Syndr 2009 52 Suppl 1 54 57 19858941
46. Strategies for more effective monitoring and evaluation systems in HIV programmatic scale-up in resource-limited settings: Implications for health systems strengthening. D Nash B Elul M Rabkin M Tun S Saito M Becker H Nuwagaba-Biribonwoha, J Acquir Immune Defic Syndr 2009 52 Supp 1 58 62 19858942
47. Using touchscreen electronic medical record systems to support and monitor national scale-up of antiretroviral therapy in Malawi. GP Douglas OJ Gadabu S Joukes S Mumba MV McKay A Ben-Smith A Jahn EJ Schouten Z Landis Lewis JJ van Oosterhout TJ AIlain R Zachariah SD Berger AD Harries F Chimbwandira, PLoS Med 2010 7 8
48. An electronic medical record system for ambulatory care of HIV-infected patients in Kenya. AM Siika JK Rotich CJ Simiyu EM Kigotho FE Smith JE Sidle K Wools-Kaloustian SN Kimaiyo WM Nyandiko TJ Hannan WM Tierney, Int J Med Inform 2005 74 5 345 355 10.1016/j.ijmedinf.2005.03.002 15893257 (Pubitemid 40694197)
49. Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenyal): a randomised trial. RT Lester P Ritvo EJ Mills A Kariri S Karanja MH Chung W Jack J Habyarimana M Sadatsafavi M Najafzadeh CA Marra B Estambale E Ngugi TB Ball L Thabane LJ Gelmon J Kimani M Ackers FA Plummer, Lancet 2010 376 9755 1838 1845 10.1016/S0140-6736(10)61997-6 21071074
50. Accelerating the implementation of the Three I's for HIV/TB and earlier initiation of ART in Southern African countries Johannesburg, South Africa, Workshop Report. WHO, 2011 http://www.stoptb.org/wg/tb-hiv/assets/documents/ Workshop%20report.pdf
51. Guidelines for intensified tuberculosis case-finding and isoniazid preventive therapy for people living with HIV in resource-constrained settings. WHO, 2011 http://whqlibdoc.who.int/publications/2011/9789241500708-eng.pdf
52. The HIV-associated tuberculosis epidemic - when will we act? AD Harries R Zachariah EL Corbett SD Lawn ET Santos-Filho R Chimzizi M Harrington D Maher BG Williams KM De Cock, Lancet 2010 375 9729 1906 1919 10.1016/S0140-6736(10) 60409-6 20488516
53. Keeping health facilities safe: one way of strengthening the interaction between disease-specific programmes and health systems. AD Harries R Zachariah K Tayler-Smith EJ Schouten F Chimbwandira W Van Damme WM EI-Sadr, Trop Med Int Health 2010 15 12 1407 1412 10.1111/j.1365-3156.2010.02662.x 21137105
54. Scaling'3 by 5' to Universal Access requires enhanced prevention. W Van Damme K Kober G Kegels M Laga, Real Health News 2006 5 29 32
55. The case for expanding access to highly active antiretroviral therapy to curb the growth of the HIV epidemic. JS Montaner R Hogg E Wood T Kerr M Tyndall AR Levy PR Harrigan, Lancet 2006 368 9534 531 536 10.1016/S0140-6736(06)69162-9 16890841 (Pubitemid 44142776)
56. Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis. D Donnell JM Baeten J Kiarie KK Thomas W Stevens CR Cohen J McIntyre JR Lingappa C Celum, Lancet 2010 375 9731 2092 2098 10.1016/S0140-6736(10)60705-2 20537376
57. Realistic Chemotherapeutic Policies for Tuberculosis in the Developing Countries. W Fox, Br Med J 1964 1 5376 135 142 10.1136/bmj.1.5376.135 14072631
58. Antiretroviral therapy for HIV prevention: many concerns and challenges, but are there ways forward in sub-Saharan Africa? R Zachariah AD Harries M Philips L Arnould K Sabapathy DP OBrien C Ferreyra S Balkan, Trans R Soc Trop Med Hyg 2010 104 6 387 391 10.1016/j.trstmh.2010.01.004 20116814
59. Auxiliaries and primary medical care. NR Fendall, Bull N Y Acad Med 1972 48 10 1291 1300 4508857
60. Antiretroviral agents used by HIV-uninfected persons for prevention: pre- and postexposure prophylaxis. RM Grant, Clin Infect Dis 2010 50 Suppl 3 96 101 20397962
61. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. RM Grant JR Lama PL Anderson V McMahan AY Liu L Vargas P Goicochea M Casapia JV Guanira-Carranza ME Ramirez-Cardich O Montoya-Herrera T Fernandez VG Veloso SP Buchbinder S Chariyalertsak M Schechter LG Bekker KH Mayer EG Kallas KR Amico K Mulligan LR Bushman RJ Hance C Ganoza P Defechereux, N Engl J Med 2010 363 27 2587 2599 10.1056/NEJMoa1011205 21091279
62. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Q Abdool Karim SS Abdool Karim JA Frohlich AC Grobler C Baxter LE Mansoor AB Kharsany S Sibeko KP Mlisana Z Omar TN Gengiah S Maarschalk N Arulappan M Mlotshwa L Morris D Taylor, Science 2010 329 5996 1168 1174 10.1126/science.1193748 20643915
63. Linking research and development to strengthen health systems in Africa. C Mgone J Volmink D Coles M Makanga S Jaffar N Sewankambo, Trop Med Int Health 2010 15 12 1404 1406 10.1111/j.1365-3156.2010.02661.x 20955373
64. The published research paper: is it an important indicator of successful operational research at programme level? R Zachariah K Tayler-Smith J Ngamvithayapong-Yana M Ota K Murakami A Ohkado N Yamada W Van Den Boogard B Draguez N Ishikawa AD Harries, Trop Med Int Health 2010 15 11 1274 1277 10.1111/j.1365-3156.2010.02630.x 20976874
65. Field Epidemiology Training Program. CDC, 2010 http://www.cdc.gov.tw/ct. asp?xItem=7726&CtNode=2488&mp=5
66. The Union and Médecins Sans Frontières approach to operational research. AD Harries ID Rusen T Reid AK Detjen SD Berger K Bissell SG Hinderaker M Edington M Fussell PI Fujiwara R Zachariah, Int J Tuberc Lung Dis 2011 15 2 144 154 21219672
67. Epidemic intelligence service of the Centers for Disease Control and Prevention: 50 years of training and service in applied epidemiology. SB Thacker AL Dannenberg DH Hamilton, Am J Epidemiol 2001 154 11 985 992 10.1093/aje/154.11.985 11724713 (Pubitemid 33121615)