Antiretroviral therapy for HIV prevention: Many concerns and challenges, but are there ways forward in sub-Saharan Africa?

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 104, Issue 6, 2010, Pages 387-391

  Zachariah, R ^a   Harries, A D ^b,c   Philips, M ^a   Arnould, L ^a   Sabapathy, K ^d   O'Brien, D P ^d   Ferreyra, C ^d   Balkan, S ^d  

^a MÉDECINS SANS FRONTIÈRES   (Belgium)

^b INTERNATIONAL UNION AGAINST TUBERCULOSIS AND LUNG DISEASE   (France)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^d MÉDECINS SANS FRONTIÈRES   (Switzerland)

Author keywords

Antiretroviral therapy; HIV; HIV testing; Prevention; Protease inhibitor monotherapy; Sub Saharan Africa

Indexed keywords

ANTIRETROVIRUS AGENT; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR;

AFRICA; ARTICLE; CD4 LYMPHOCYTE COUNT; COST EFFECTIVENESS ANALYSIS; DRUG EFFICACY; DRUG SAFETY; FEASIBILITY STUDY; HEALTH CARE DELIVERY; HEALTH CARE FACILITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN RIGHTS; INCIDENCE; MATHEMATICAL MODEL; PATIENT COMPLIANCE; PUBLIC HEALTH; SCREENING;

AFRICA SOUTH OF THE SAHARA; ANTI-RETROVIRAL AGENTS; DEVELOPING COUNTRIES; HEALTH SERVICES NEEDS AND DEMAND; HIV INFECTIONS; HUMANS; MASS SCREENING; MODELS, THEORETICAL; PATIENT ACCEPTANCE OF HEALTH CARE; TIME FACTORS;

EID: 77952675993     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trstmh.2010.01.004     Document Type: Article

References (24)

1. Granich R.M., Gilks C.F., Dye C., De Cock K.M., Williams B.G. Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet 2009, 373:48-57.
2. Ruark A., Shelton J.D., Halperin D.T., Wawer M.J., Gray R.H. Universal voluntary HIV testing and immediate antiretroviral therapy. Lancet 2009, 373:1078. author reply 1080-1.
3. Epstein H. Universal voluntary HIV testing and immediate antiretroviral therapy. Lancet 2009, 373:1079. author reply 1080-1.
4. Jürgens R., Cohen J., Tarantola D., Heywood M., Carr R. Universal voluntary HIV testing and immediate antiretroviral therapy. Lancet 2009, 373:1079. author reply 1080-1.
5. UNAIDS and the World Health Organization. AIDS epidemic update. Progress report 2009. UNAIDS/WHO. UNAIDS/09.36E/JC1700E. [accessed 24 December 2009]. http://data.unaids.org/pub/Report/2009/2009_epidemic_update_en.pdf.
6. Harries A.D. HIV/AIDS: The long haul ahead. Int J Tuberc Lung Dis 2008, 12:1347-1348.
7. United Nations Millennium Development Goals. [accessed 18 April 2009]. http://www.un.org/millenniumgoals/aids.shtml.
8. Kitahata M.M., Gange S.J., Abraham A.G., Merriman B., Saag M.S., Justice A.C., et al. NA-ACCORD Investigators. Effect of early versus deferred antiretroviral therapy for HIV on survival. N Engl J Med 2009, 360:1815-1826.
9. When To Start Consortium; Sterne JA, May M, Costagliola D, de Wolf F, Phillips AN, Harris R, et al. Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. Lancet 2009; 373:1352-63.
10. WHO. Antiretroviral therapy for HIV infection in adults and adolescents. Recommendations for a public health approach (2006 revision). Geneva: World Health Organization. [accessed 24 December 2009]. http://www.who.int/hiv/pub/arv/adult/en/index.html.
11. McKinnon J.E., Mellors J.W., Swindells S. Simplification strategies to reduce antiretroviral drug exposure: progress and prospects. Antivir Ther 2009, 14:1-12.
12. Labarga P., Barreiro P., Martin-Carbonero L., Rodriguez-Novoa S., Solera C., Medrano J., et al. Kidney tubular abnormalities in the absence of impaired glomerular function in HIV patients treated with tenofovir. AIDS 2009, 23:689-696.
13. Swindells S., DiRienzo A.G., Wilkin T., Fletcher C.V., Margolis D.M., Thal G.D., et al. Regimen simplification to atazanavir-ritonavir alone as maintenance antiretroviral therapy after sustained virologic suppression. JAMA 2006, 296:806-814. AIDS Clinical Trials Group 5201 Study Team.
14. Bierman W.F., van Agtmael M.A., Nijhuis M., Danner S.A., Boucher C.A. HIV monotherapy with ritonavir-boosted protease inhibitors: a systematic review. AIDS 2009, 23:279-291.
15. von Hentig N. Atazanavir/ritonavir: a review of its use in HIV therapy. Drugs Today (Barc) 2008, 44:103-132.
16. WHO. Taking stock: health worker shortages and the response to AIDS. Geneva: World Health Organization; 2006. [accessed 20 April 2009]. http://www.who.int/hiv/pub/advocacy/ttr/en/index.html.
17. Zachariah R., Ford N., Philips M., Lynch S., Massaquoi M., Janssens V., et al. Task shifting in HIV/AIDS: opportunities, challenges and proposed actions for sub-Saharan Africa. Trans R Soc Trop Med Hyg 2009, 103:549-558.
18. Philips M., Zachariah R., Venis S. Task shifting for antiretroviral treatment in sub-Saharan Africa: not a panacea. Lancet 2008, 371:682-684.
19. Hermann K., Van Damme W., Pariyo G.W., Schouten E., Assefa Y., Cirera A., et al. Community health workers for ART in sub-Saharan Africa: learning from experience-capitalizing on new opportunities. Hum Resour Health 2009, 7:31.
20. Harries A.D., Schouten E.J., Makombe S.D., Libamba E., Neufville H.N., Some E., et al. Ensuring uninterrupted supplies of antiretroviral drugs in resource-poor settings: an example from Malawi. Bull World Health Organ 2007, 85:152-155.
21. Harries A.D., Gomani P., Teck R., de Teck O.A., Bakali E., Zachariah R., et al. Monitoring the response to antiretroviral therapy in resource-poor settings: the Malawi model. Trans R Soc Trop Med Hyg 2004, 98:695-701.
22. Rosen S., Fox M.P., Gill C.J. Patient retention in antiretroviral therapy programs in sub-Saharan Africa: a systematic review. PLoS Med 2007, 4:e298.
23. Wilson D., Keiluhu A.K., Kogrum S., Reid T., Seriratana N., Ford N., et al. HIV-1 viral load monitoring: an opportunity to reinforce treatment adherence in a resource-limited setting in Thailand. Trans R Soc Trop Med Hyg 2009, 103:601-606.
24. Harries A.D., Makombe S.D., Schouten E.J., Ben-Smith A., Jahn A. Different delivery models for antiretroviral therapy in sub-Saharan Africa in the context of 'universal access'. Trans R Soc Trop Med Hyg 2008, 102:310-311.