Genetic manipulation of pathway regulation for overproduction of angucycline-like antibiotic auricin in Streptomyces aureofaciens CCM 3239

Folia Microbiologica

Volumn 56, Issue 3, 2011, Pages 276-282

  Novakova, Renata ^a   Rehakova, Alena ^a   Feckova, Lubomira ^a   Kutas, Peter ^a   Knischova, Renata ^a   Kormanec, Jan ^a  

^a Institute of Molecular Biology Slovak Academy of Sciences   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; AURICIN; BACTERIAL DNA; MACROLIDE;

ARTICLE; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; MULTIGENE FAMILY; PLASMID; PROMOTER REGION; RESTRICTION MAPPING; STREPTOMYCES AUREOFACIENS;

ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; MACROLIDES; MULTIGENE FAMILY; PLASMIDS; PROMOTER REGIONS, GENETIC; RESTRICTION MAPPING; STREPTOMYCES AUREOFACIENS;

STREPTOMYCES AUREOFACIENS;

EID: 79960061451     PISSN: 00155632     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12223-011-0033-1     Document Type: Article

References (19)

1. Ausubel FM, Brent R, Kingston RE, Moore DO, Seidman JS, Smith JA, Struhl K (1995) Current protocols in molecular biology. Wiley, New York.
2. Bibb M (2005) Regulation of secondary metabolism in streptomyces. Curr Opin Microbiol 8: 208-215.
3. Gust B, Challis GL, Fowler K, Kieser T, Chater KF (2003) PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin. Proc Natl Acad Sci USA 18: 1541-1548.
4. Kieser T, Bibb MJ, Buttner MJ, Chater KF, Hopwood DA (2000) Practical streptomyces genetics. The John Innes Foundation, Norwich.
5. Kormanec J (2001) Analyzing the developmental expression of sigma factors with S1 -nuclease mapping. Methods in Molecular Biology, vol. 160. In: Chein CH (ed) Nuclease methods and protocols. Humana Press, Totowa, pp 481-494.
6. Kormanec J, Farkasovsky M (1993) Differential expression of principal σ factor homologues of Streptomyces aureofaciens correlates with the developmental stage. Nucl Acids Res 21: 3647-3652.
7. Lombo F, Brana AF, Salas JA, Mendez C (2004) Genetic organization of the biosynthetic gene cluster for the antitumor angucycline oviedomycin in Streptomyces antibioticus ATCC 11891. Chembiochem 5: 1181-1187.
8. Luzhetskyy A, Zhu L, Gibson M, Fedoryshyn M, Dürr C, Hofmann C, Hoffmeister D, Ostash B, Mattingly C, Adams V, Fedorenko V, Rohr J, Bechthold A (2005) Generation of novel landomycins M and O through targeted gene disruption. Chembiochem 6: 675-678.
9. Martin J-F, Liras P (2010) Engineering of the regulatory cascades ant networks controlling antibiotic biosynthesis in Streptomyces. Curr Option Microbiol 13: 263-273.
10. Maxam AM, Gilbert W (1980) Sequencing end-labelled DNA with base specific chemical cleavages. Meth Enzymol 65: 449-560.
11. Metsa-Ketela M, Ylihonko K, Mantsala P (2004) Partial activation of a silent angucycline-type gene cluster from a rubromycin β producing Streptomyces sp. PGA64. J Antibiot 57: 502-510.
12. Novakova R, Bistakova J, Homerova D, Rezuchova B, Kormanec J (2002) Cloning and characterization of a polyketide synthase gene cluster involved in biosynthesis of a proposed angucycline-like polyketide auricin in Streptomyces aureofaciens CCM3239. Gene 297: 197-208.
13. Novakova R, Homerova D, Feckova L, Kormanec J (2005) Characterization of a regulatory gene essential for the production of the angucycline-like polyketide auricin in Streptomyces aureofaciens CCM3239. Microbiol SGM 151: 2693-2706.
14. Novakova R, Odnogova Z, Kutas P, Feckova L, Kormanec J (2010a) Identification and characterization of an Indigoidine-like gene for a blue pigment biosynthesis in Streptomyces aureofaciens CCM3239. Folia Microbiol 55(2): 119-125.
15. Novakova R, Kutas P, Feckova L, Kormanec J (2010b) The role of the TerR-family transcriptional regulator Aur1R in negative regulation of the auricin gene cluster in Streptomyces aureofaciens CCM3239. Microbiol SGM 156: 2374-2383.
16. Novakova R, Rehakova A, Kutas P, Feckova L, Kormanec J (2011) The role of two SARP-family transcriptional regulators in regulation of the auricin gene cluster in Streptomyces aureofaciens CCM3239. Microbiology-SGM DOI:. doi: 10. 1099/mic. 0. 047795-0.
17. Pang X, Aigle B, Girardet J-M, Mangenot S, Pernodet J-L, Decaris B, Leblond P (2004) Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome. Antimicrob Agents Chemother 48: 557-558.
18. Smokvina T, Mazodier P, Boccard F, Thompson CJ, Guerineau M (1990) Construction of a series of pSAM2-based integrative vectors for use in actinomycetes. Gene 94: 53-59.
19. Zheng JT, Wang SL, Yang KQ (2007) Engineering a regulatory region of jadomycin gene cluster to improve jadomycin B production in Streptomyces venezuelae. Appl Microbiol Biotechnol 76: 883-888.