Treatment of malignant migrating partial epilepsy of infancy with rufinamide: Report of five cases

Epileptic Disorders

Volumn 13, Issue 1, 2011, Pages 18-21

  Vendrame, Martina ^a,b   Poduri, Annapurna ^a   Loddenkemper, Tobias ^a   Kluger, Gerhard ^c   Coppola, Giangennaro ^d   Kothare, Sanjeev V ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BOSTON UNIVERSITY   (United States)

^c Klinik fur Neuropadiatrie und Neurologische Rehabilitation   (Germany)

^d SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

bromide; electroencephalogram; migrating epilepsy of infancy; multi focal; rufinamide

Indexed keywords

CLONAZEPAM; ETIRACETAM; LAMOTRIGINE; POTASSIUM BROMIDE; RUFINAMIDE; TOPIRAMATE; ZONISAMIDE; ANTICONVULSIVE AGENT; TRIAZOLE DERIVATIVE;

ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE CLASSIFICATION; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; ELECTROENCEPHALOGRAPHY; EPILEPTIC DISCHARGE; FEMALE; FOCAL EPILEPSY; HUMAN; INFANT; KETOGENIC DIET; MALE; MALIGNANT MIGRATING PARTIAL EPILEPSY IN INFANCY; MONOTHERAPY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; TREATMENT DURATION; TREATMENT PLANNING; VOMITING; BRAIN; CASE REPORT; PATHOPHYSIOLOGY; TREATMENT OUTCOME;

ANTICONVULSANTS; BRAIN; CHILD, PRESCHOOL; ELECTROENCEPHALOGRAPHY; EPILEPSIES, PARTIAL; FEMALE; HUMANS; MALE; TREATMENT OUTCOME; TRIAZOLES;

EID: 79960061294     PISSN: 12949361     EISSN: 19506945     Source Type: Journal    
DOI: 10.1684/epd.2011.0406     Document Type: Article

References (19)

1. V. Biton J.C. Sackellares A. Vuong A.E. Hammer P.S. Barrett J.A. Messenheimer 2005 Double-blind, placebo-controlled study of lamotrigine in primary generalized tonic-clonic seizures Neurology 65 1737 1743 16344515 10.1212/01.wnl.0000187118.19221.e4 1:CAS:528:DC%2BD2MXht1art77I
2. Biton V, Krauss G, Vasquez-Santana B, et al. A randomized, double-blind, placebo-controlled, parallel-group study of rufinamide as adjunctive therapy for refractory partial-onset seizures. Epilepsia 2010 (in press).
3. M.J. Brodie W.E. Rosenfeld B. Vazquez, et al. 2009 Rufinamide for the adjunctive treatment of partial seizures in adults and adolescents: a randomized placebo-controlled trial Epilepsia 50 1899 1909 19490053 10.1111/j.1528-1167. 2009.02160.x 1:CAS:528:DC%2BD1MXhtV2itLvP
4. A. Cheng-Hakimian G.D. Anderson J.W. Miller J.W. Rufinamide 2006 Pharmacology, clinical trials, and role in clinical practice Int J Clin Pract 60 1497 1501 17073844 10.1111/j.1742-1241.2006.01173.x 1:CAS:528: DC%2BD28Xhtlajt7%2FL (Pubitemid 44560351)
5. G. Coppola P. Plouin C. Chiron O. Robain O. Dulac 1995 Migrating partial seizures in infancy: a malignant disorder with developmental arrest Epilepsia 36 1017 1024 7555952 10.1111/j.1528-1157.1995.tb00961.x 1:STN:280: DyaK28%2Fgslaqug%3D%3D
6. G. Coppola F.F. Operto G. Auricchio A. D'Amico D. Fortunato A. Pascotto 2007 Temporal lobe dual pathology in malignant migrating partial seizures in infancy Epileptic Disord 9 145 148 17525023 (Pubitemid 47013802)
7. G. Coppola 2009 Malignant migrating partial seizures in infancy: an epilepsy syndrome of unknown etiology Epilepsia 50 49 51 19469847 10.1111/j.1528-1167.2009.02121.x
8. G. Coppola S. Grosso E. Franzoni, et al. 2010 Rufinamide in children and adults with Lennox-Gastaut syndrome: First Italian multicenter experience Seizure 19 587 591 20888268 10.1016/j.seizure.2010.09.008
9. G. Coppola S. Grosso E. Franzoni, et al. 2011 Rufinamide in refractory childhood epileptic encephalopathies other than Lennox-Gastaut syndrome Eur J Neurol 18 246 251 20666837 10.1111/j.1468-1331.2010.03113.x 1:STN:280: DC%2BC3M7msFGmtQ%3D%3D
10. T. Glauser G. Kluger R. Sachdeo G. Krauss C. Perdomo S. Arroyo 2008 Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome Neurology 70 1950 1958 18401024 10.1212/01.wnl.0000303813.95800.0d 1:CAS:528:DC%2BD1cXlvVCmtrs%3D
11. G. Hmaimess H. Kadhim M.C. Nassogne C. Bonnier K. van Rijckevorsel 2006 Levetiracetam in a neonate with malignant migrating partial seizures Pediatr Neurol 34 55 59 16376281 10.1016/j.pediatrneurol.2005.06.011 (Pubitemid 41821012)
12. G. Kluger G. Kurlemann E. Haberlandt, et al. 2009 Effectiveness and tolerability of rufinamide in children and adults with refractory epilepsy: first European experience Epilepsy Behav 14 491 495 19162229 10.1016/j.yebeh.2008.12.013
13. G. Kluger E. Haberlandt G. Kurlemann, et al. 2010 First European long-term experience with the orphan drug rufinamide in childhood-onset refractory epilepsy Epilepsy Behav 17 546 548 20185372 10.1016/j.yebeh.2010.01. 005
14. K. Okuda A. Yasuhara A. Kamei A. Araki N. Kitamura Y. Kobayashi 2000 Successful control with bromide of two patients with malignant migrating partial seizures in infancy Brain Dev 22 56 59 10761836 10.1016/S0387-7604(99)00108-4 1:STN:280:DC%2BD3c3it1CksQ%3D%3D (Pubitemid 30052995)
15. S. Palhagen R. Canger O. Henriksen J.A. van Parys M.E. Riviere M.A. Karolchyk 2001 Rufinamide: a double-blind, placebocontrolled proof of principle trial in patients with epilepsy Epilepsy Res 43 115 124 11164700 10.1016/S0920-1211(00)00185-6 1:CAS:528:DC%2BD3MXnsVKmtQ%3D%3D (Pubitemid 32115522)
16. J. Perez C. Chiron C. Musial, et al. 1999 Stiripentol: efficacy and tolerability in children with epilepsy Epilepsia 40 1618 1626 10565591 10.1111/j.1528-1157.1999.tb02048.x 1:CAS:528:DyaK1MXnslGiu78%3D (Pubitemid 29518093)
17. E. Perucca J. Cloyd D. Critchley E. Fuseau 2008 Rufinamide: clinical pharmacokinetics and concentration-response relationships in patients with epilepsy Epilepsia 49 1123 1141 18503564 10.1111/j.1528-1167.2008.01665.x 1:CAS:528:DC%2BD1cXpslWmtLw%3D (Pubitemid 351991401)
18. M. Vendrame T. Loddenkemper V. Gooty, et al. 2010 Experience with rufinamide in a pediatric population: a single center's experience Pediatric Neurology 43 155 158 20691934 10.1016/j.pediatrneurol.2010.04.003
19. J.W. Wheless B. Vazquez 2010 Rufinamide: a novel broad-spectrum antiepileptic drug Epilepsy Curr 10 1 6 20126329 10.1111/j.1535-7511.2009.01336. x