Effect of Ukrain on cell survival and apoptosis in the androgen-independent prostate cancer cell line PC-3

Journal of Environmental Pathology, Toxicology and Oncology

Volumn 30, Issue 1, 2011, Pages 11-19

  Venkatesh, Kavitha ^a   Govindaraj, Sharmila ^a   Ramachandran, Arunkumar ^a   Kalimuthu, Senthilkumar ^a   Perumal, Elumalai ^a   Velayutham, Sivakamasundari ^a   Jagadeesan, Arunakaran ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Akt; Apoptosis; DAPI; DNA fragmentation; Prostate cancer; Ukrain

Indexed keywords

ANDROGEN; CASPASE 10; FAS LIGAND; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; UKRAIN;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CELL VIABILITY; DNA FRAGMENTATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

CHELIDONIUM; CHELIDONIUM MAJUS;

EID: 79960052174     PISSN: 07318898     EISSN: None     Source Type: Journal    
DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i1.20     Document Type: Article

References (25)

1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics. CA Cancer J Clin. 2008;57:43-66.
2. Denis LJ, Grifiths K. Endocrine treatment in prostate cancer. Sem Surg Oncol. 2000;18:52-74.
3. Osaki M, Oshimura M, Ito H. PI3K-Akt pathway its functions and alterations in human cancer. Apoptosis. 1993;9:667-76.
4. Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase-AKT pathways in human cancer. Nat Rev. 2002;2:488-500.
5. Steck PA, Pershouse MA, Jasser SA. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet. 1997;15:356-62.
6. Vermeulen K, Van Bockstaele DR, Berneman ZN. Apoptosis: mechanisms and relevance in cancer. Ann Hematol. 2005;84:627-39.
7. Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998;281:1309-12.
8. Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell. 2001;104:487-501.
9. Vincenz C, Dixit VM. Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95-and p55-mediated death signaling. J Biol Chem. 1997;272:6578-83.
10. Nowicky J, Staniszewski A, Zbroja-Sontag W, Slesak B, Nowicky W, Hiesmayr W. Evaluation of thiophoshoric acid alkaloid derivates from Chelidonium majus L. ("Ukrain") as an immunostimulant in patients with various carcinomas. Drugs Exp Clin Res. 1991;17(2):139-43.
11. Liepins A, Nowicky JW, Bustamante JC, Lam E. Induction of bimodal programmed cell death in malignant cells by the derivatives of Ukrain. Drugs Exp Clin Res. 1996;22(3-5):73-9.
12. Potopalsky AI, Nowicky JW. Semisynthetic antitumor alkaloid derivatives as antiviral and potential anti-HIV preparations (Abstract). Antivir Res. 1993;20:57.
13. Reed JC, Paternostro G. Bcl-2 family proteins. Proc Natl Acad Sci U S A. 1999;96:7614-6.
14. Nowicky JW, Manolakis G, Meijer D, Vatanasapt V, Brzosko WJ. Ukrain both as an anticancer and immunoregulatory agent. Drugs Exp Clin Res. 1992;18:51-4.
15. Koshelnick Y, Moskvina E, Binder BR, Nowicky JW. Ukrain (NSC-631570) inhibits angiogenic differentiation of human endothelial cells in vitro. Proceedings of the 17th International Cancer Congress; 1998 August 24-28; Rio de Janeiro, Brazil 1998. p. 91-95.
16. Hohenwarter O, Strutzenberg K, Katninger H, Liepins A, Nowicky JW. Selective inhibition of in vitro cell growth byn the anti-tumour drug Ukrain. Drugs Exp Clin Res. 1992;18(suppl):1-4.
17. Nowicky JW, Nowicky W, Liepins A. Cytotastic and cytotoxic effects of Ukrain on malignant cells. Proceedings of the VIII Mediterranean Congress of Chemotherapy, 1992 May 24-29, Athens, Greece, Journal of Chemotherapy, Supplement n. 1, Volume 5, 797, 1993.
18. Grinevich Y, Shalimov S, Bendyuh G, Zahriychuk O, Hodysh Y. Effect of Ukrain on the growth and metastasizing of Lewis carcinoma in C57BL16 mice. Drugs Exp Clin Res. 2005;31:59-70.
19. Ernst E, Schmidt K. Ukrain--A new cancer cure? A systematic review of randomised clinical trials. BMC Cancer. 2005;5:69.
20. Kurochkin SN, Kolobkov SL, Votrin II, Voltchek IV. Induction of apoptosis in cultured Chinese hamster ovary cells by Ukrain and its synergistic action with etoposide. Drugs Exp Clin Res. 2008;26:275-8.
21. Vukanovic J, Isaacs JT. Linomide inhibits angiogenesis, growth, metastasis, and macrophage infiltration within rat prostatic cancers. Cancer Res. 1995;55(7):1499-504.
22. Li CJ, Wang C, Pardee BV. Induction of apoptosis by lapachone in human prostate cancer cells. Cancer Res. 1995;55(17):3712-5.
23. Roublevskaia IN, Haake AR, Ludlow JW, Polevoda BV. Induced apoptosis in human prostate cancer cell line LNCaP by Ukrain. Drugs Exp Clin Res. 2000;26:141-7.
24. Roublevskaia IN, Haake AR, Polevoda BV. Bcl-2 overexpression protects human keratinocyte cells from Ukrain induced apotosis but not from G2/M arrest. Drugs Exp Clin Res. 2000;26:149-56.
25. Nicholson KM, Anderson NG. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal. 2002;14:381-95.