Metabolism of aflatoxin B1 in Turkey liver microsomes: The relative roles of cytochromes P450 1A5 and 3A37

Toxicology and Applied Pharmacology

Volumn 254, Issue 3, 2011, Pages 349-354

  Rawal, Sumit ^a   Coulombe, Roger A ^a  

^a UTAH STATE UNIVERSITY   (United States)

Author keywords

Aflatoxin B1; Bioactivation; Cytochrome P450; Metabolism; Turkeys

Indexed keywords

AFLATOXIN B1; AFLATOXIN M1; AFLATOXIN Q1; CYTOCHROME; CYTOCHROME P450 1A5; CYTOCHROME P450 3A37; MYCOTOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DETOXIFICATION; ENZYME MECHANISM; EPOXIDATION; LIVER MICROSOME; LIVER MICROSOME METABOLISM; MICHAELIS MENTEN KINETICS; NONHUMAN; TURKEY (BIRD);

AFLATOXIN B1; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; MICROSOMES, LIVER; TURKEYS;

ANIMALIA;

EID: 79960050070     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.05.010     Document Type: Article

References (36)

1. Andersson T., Miners J.O., Veronese M.E., Birkett D.J. Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms. Br. J. Clin. Pharmacol. 1994, 38:131-137.
2. Arafa A.S., Bloomer R.J., Wilson H.R., Simpson C.F., Harms R.H. Susceptibility of various poultry species to dietary aflatoxin. Br. Poult. Sci. 1981, 22:431-436.
3. Ball R.W., Coulombe R.A. Comparative biotransformation of aflatoxin B1 in mammalian airway epithelium. Carcinogenesis 1991, 12:305-310.
4. Bintvihok A., Thiengnin S., Doi K., Kumagai S. Residues of aflatoxins in the liver, muscle and eggs of domestic fowls. J. Vet. Med. Sci. 2002, 64:1037-1039.
5. Bondy G.S., Pestka J.J. Immunomodulation by fungal toxins. J. Toxicol. Environ. Health B Crit. Rev. 2000, 3:109-143.
6. Carnaghan R.B., Lewis G., Patterson D.S., Allcroft R. Biochemical and pathological aspects of groundnut poisoning in chickens. Pathol. Vet. 1966, 3:601-615.
7. CAST Council for agricultural science and technology. Mycotoxins: Economic and Health Risks 1989, 116. CAST, Ames, IA.
8. Coulombe R.A. Biological action of mycotoxins. J. Dairy Sci. 1993, 76:880-891.
9. Coulombe R.A., Guarisco J.A., Klein P.J., Hall J.O. Chemoprevention of aflatoxicosis in poultry by dietary butylated hydroxytoluene. Anim. Feed Sci. Technol. 2005, 121:217-225.
10. Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Ann Blomberg L., Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K., Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C., Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A., Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M. Multi-platform next-generation sequencing of the domestic turkey (Meleagris gallopavo): genome assembly and analysis. PLoS Biol. 2010, 8.
11. Davydov D.R., Halpert J.R. Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both?. Expert Opin. Drug Metab. Toxicol. 2008, 4:1523-1535.
12. Gallagher E.P., Wienkers L.C., Stapleton P.L., Kunze K.L., Eaton D.L. Role of human microsomal and human complementary DNA-expressed cytochromes P4501A2 and P4503A4 in the bioactivation of aflatoxin B1. Cancer Res. 1994, 54:101-108.
13. Gallagher E.P., Kunze K.L., Stapleton P.L., Eaton D.L. The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4. Toxicol. Appl. Pharmacol. 1996, 141:595-606.
14. Giambrone J.J., Diener U.L., Davis N.D., Panangala V.S., Hoerr F.J. Effects of aflatoxin on young turkeys and broiler chickens. Poult. Sci. 1985, 64:1678-1684.
15. Guarisco J.A., Hall J.O., Coulombe R.A. Mechanisms of butylated hydroxytoluene chemoprevention of aflatoxicosis-inhibition of aflatoxin B1 metabolism. Toxicol. Appl. Pharmacol. 2008, 227:339-346.
16. Hayes J.D., Judah D.J., McLellan L.I., Neal G.E. Contribution of the glutathione S-transferases to the mechanisms of resistance to aflatoxin B1. Pharmacol. Ther. 1991, 50:443-472.
17. Hayes J.D., Judah D.J., Neal G.E., Nguyen T. Molecular cloning and heterologous expression of a cDNA encoding a mouse glutathione S-transferase Yc subunit possessing high catalytic activity for aflatoxin B1-8,9-epoxide. Biochem. J. 1992, 285(Pt 1):173-180.
18. Huff W.E., Kubena L.F., Harvey R.B., Corrier D.E., Mollenhauer H.H. Progression of aflatoxicosis in broiler chickens. Poult. Sci. 1986, 65:1891-1899.
19. Kamdem L.K., Meineke I., Godtel-Armbrust U., Brockmoller J., Wojnowski L. Dominant contribution of P450 3A4 to the hepatic carcinogenic activation of aflatoxin B1. Chem. Res. Toxicol. 2006, 19:577-586.
20. Kim J.E., Bauer M.M., Mendoza K.M., Reed K.M., Coulombe R.A. Comparative genomics identifies new alpha class genes within the avian glutathione S-transferase gene cluster. Gene 2010, 452:45-53.
21. Klein P.J., Buckner R., Kelly J., Coulombe R.A. Biochemical basis for the extreme sensitivity of turkeys to aflatoxin B1. Toxicol. Appl. Pharmacol. 2000, 165:45-52.
22. Klein P.J., Van Vleet T.R., Hall J.O., Coulombe R.A. Biochemical factors underlying the age-related sensitivity of turkeys to aflatoxin B1. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2002, 132:193-201.
23. Kubena L.F., Edrington T.S., Kamps-Holtzapple C., Harvey R.B., Elissalde M.H., Rottinghaus G.E. Effects of feeding fumonisin B1 present in Fusarium moniliforme culture material and aflatoxin singly and in combination to turkey poults. Poult. Sci. 1995, 74:1295-1303.
24. Kullman S.W., Kashiwada S., Hinton D.E. Analysis of medaka cytochrome P450 3A homotropic and heterotropic cooperativity. Mar. Environ. Res. 2004, 58:469-473.
25. Omura T., Sato R. The carbon monoxide-binding pigment of liver microsomes. Ii. Solubilization, purification, and properties. J. Biol. Chem. 1964, 239:2379-2385.
26. Ramsdell H.S., Eaton D.L. Species susceptibility to aflatoxin B1 carcinogenesis: comparative kinetics of microsomal biotransformation. Cancer Res. 1990, 50:615-620.
27. Rawal S., Mendoza K.M., Reed K.M., Coulombe R.A. Structure, genetic mapping, and function of the cytochrome P450 3A37 gene in the turkey (Meleagris gallopavo). Cytogenet. Genome Res. 2009, 125:67-73.
28. Rawal S., Kim J.E., Coulombe R. Aflatoxin B1 in poultry: toxicology, metabolism and prevention. Res. Vet. Sci. 2010, 89:325-331.
29. Rawal S., Yip S.S., Coulombe R.A. Cloning, expression and functional characterization of cytochrome P450 3A37 from turkey liver with high aflatoxin B1 epoxidation activity. Chem. Res. Toxicol. 2010, 23:1322-1329.
30. Shimada T., Guengerich F.P. Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver. Proc. Natl. Acad. Sci. U. S. A. 1989, 86:462-465.
31. Smith K.M. Disease of turkey poults. Vet. Rec. 1960, 72:652.
32. Ueng Y.F., Shimada T., Yamazaki H., Guengerich F.P. Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes. Chem. Res. Toxicol. 1995, 8:218-225.
33. Ueng Y.F., Kuwabara T., Chun Y.J., Guengerich F.P. Cooperativity in oxidations catalyzed by cytochrome P450 3A4. Biochemistry 1997, 36:370-381.
34. Wogan G.N., Paglialunga S., Newberne P.M. Carcinogenic effects of low dietary levels of aflatoxin B1 in rats. Food Cosmet. Toxicol. 1974, 12:681-685.
35. Wong J.J., Hsieh D.P. Mutagenicity of aflatoxins related to their metabolism and carcinogenic potential. Proc. Natl. Acad. Sci. U. S. A. 1976, 73:2241-2244.
36. Yip S.S., Coulombe R.A. Molecular cloning and expression of a novel cytochrome p450 from turkey liver with aflatoxin b1 oxidizing activity. Chem. Res. Toxicol. 2006, 19:30-37.