Development and validation of a UPLC-MS/MS method for quantification of SKLB010, an investigational anti-inflammatory compound, and its application to pharmacokinetic studies in beagle dogs

Journal of Pharmaceutical and Biomedical Analysis

Volumn 56, Issue 2, 2011, Pages 366-372

  Ye, Xia ^a   Tang, Minghai ^a   Liu, Juan ^a   Wang, Xianhuo ^a   Ma, Liang ^a   Zheng, Hao ^a   Hu, Jia ^a   Chen, Xiang ^a   Duan, Xingmei ^a   Chen, Lijuan ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Beagle dog; SKLB010; Solid phase extraction; UPLC MS MS

Indexed keywords

5 (4 METHOXYBENZYLIDENE)THIAZOLIDINE 2,4 DIONE; ANTIINFLAMMATORY AGENT; ROSIGLITAZONE; SKLB 010; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DOG; DRUG DETERMINATION; DRUG HALF LIFE; DRUG ISOLATION; DRUG MONITORING; DRUG STABILITY; DRUG STRUCTURE; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; CALIBRATION; CHROMATOGRAPHY, LIQUID; DOGS; DRUG STABILITY; GUIDELINE ADHERENCE; GUIDELINES AS TOPIC; METHANOL; MODELS, BIOLOGICAL; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; THIAZOLIDINEDIONES; WATER;

EID: 79960049838     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.05.031     Document Type: Article

References (19)

1. Luo Y.F., Ma L., Zheng H., Chen L.J., Li R., He C.M., Yang S.Y., Ye X., Chen Z.Z., Li Z.C., Gao Y., Han J., He G., Yang L., Wei Y.Q. Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice. J. Med. Chem. 2010, 53:273-281.
2. Ma Y.H., Wang X.H., Wu X.H., Wei X., Ma L., Zheng H., Qi B.W., Luo Y.F., Wei Y.Q., Chen L.J. (Z)-5-(4-methoxybenzylidene) thiazolidine-2,4-dione ameliorates the adjuvant-induced arthritis via inhibiting the migration of macrophage and down-regulating the cytokine mRNA expression. Int. Immunopharmacol. 2010, 10:1456-1462.
3. Yardi{dotless}mci{dotless} C., Özalti{dotless}n N., G̈urlek A. Simultaneous determination of rosiglitazone and metformin in plasma by gradient liquid chromatography with UV detection. Talanta 2007, 72:1416-1422.
4. Kang X., Wang F., Xie Z.H., Li H.D. A high performance liquid chromatography method for simultaneous determination of rosiglitazone and gemfibrozil in human plasma. J. Chromatogr. B 2009, 877:645-648.
5. Sun N., Lin M., Fan G.R., Hong Z.Y., Lu G.C. Quantitative determination of MCC-555, a novel insulin sensitizer in beagle dog plasma by high-performance liquid chromatography with fluorescence detection. J. Chromatogr. B 2006, 835:35-39.
6. Yardi{dotless}mci{dotless} C., Özalti{dotless}n N. Method development and validation for the simultaneous determination of rosiglitazone and metformin in pharmaceutical preparations by capillary zone electrophoresis. Anal. Chim. Acta 2005, 549:88-95.
7. Wood M., Laloup M., Samyn N., del Mar M., Fernandez R., de Bruijn E.A., Maes R.A.A., De Boeck G. Recent applications of liquid chromatography-mass spectrometry in forensic science. J. Chromatogr. A 2006, 1130:3-15.
8. Plumb R., Castro-Perez J., Granger J., Beattie I., Joncour K., Wright A. Ultra-performance liquid chromatography coupled to quadrupole-orthogonal time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 2004, 18:2331-2337.
9. Ho E.N.M., Yiu K.C.H., Wan T.S.M., Stewart B.D., Watkins K.L. Detection of anti-diabetics in equine plasma and urine by liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 2004, 811:65-73.
10. Chou C.C., Lee M.R., Cheng F.C., Yang D.Y. Solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry for determination of trace rosiglitazone in urine. J. Chromatogr. A 2005, 1097:74-83.
11. Riffel K.A., Polinko M.A., Song H.C., Rippley R.K., Lo M.W. Quantitative determination of a novel insulin sensitizer and its para-hydroxylated metabolite in human plasma by LC-MS/MS. J. Pharm. Biomed. Anal. 2004, 35:523-534.
12. de Villiers A., Lestremau F., Szucs R., Góelóebart S., David F., Sandra P. Evaluation of ultra performance liquid chromatography. J. Chromatogr. A 2006, 1127:60-69.
13. Churchwell M.I., Twaddle N.C., Meeker L.R., Doerge D.R. Improving LC-MS sensitivity through increases in chromatographic performance: comparisons of UPLC-ES/MS/MS to HPLC-ES/MS/MS. J. Chromatogr. B 2005, 825:134-143.
14. Pedraglio S., Rozio M.G., Misiano P., Reali V., Dondio G., Bigogno C. New perspectives in bio-analytical techniques for preclinical characterization of a drug candidate: UPLC-MS/MS in vitro metabolism and pharmacokinetic studies. J. Pharm. Biomed. Anal. 2007, 44:665-673.
15. U.S. Department of Health and Human Services, Food and Drug Administration Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CVM), 2001.
16. New L.S., Saha S., Ong M.M.K., Boelsterli U.A., Chan E.C.Y. Pharmacokinetic study of intraperitoneally administered troglitazone in mice using ultra-performance liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2007, 21:982-988.
17. Kim K.B., Lee D.J., Yeo C.W., Shin J.G., Bae S.K. Simultaneous quantification of rosiglitazone and its two major metabolites, N-desmethyl and p-hydroxy rosiglitazone in human plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study. J. Chromatogr. B 2009, 877:1951-1956.
18. Lin Z.P.J., Ji W.H., Desai-Krieger D., Shum L. Simultaneous determination of pioglitazone and its two active metabolites in human plasma by LC-MS/MS. J. Pharm. Biomed. Anal. 2003, 33:101-108.
19. He J., Hu Y.F., Duan L.F., Tan Z.R., Wang L.S., Wang D., Zhang W., Li Z., Liu J., Tu J.H., Yao Y.M., Zhou H.H. Sensitive and selective liquid chromatography-mass spectrometry method for the quantification of rosiglitazone in human plasma. J. Pharm. Biomed. Anal. 2007, 43:580-585.