Quantitative determination of a novel insulin sensitizer and its para-hydroxylated metabolite in human plasma by LC-MS/MS

Journal of Pharmaceutical and Biomedical Analysis

Volumn 35, Issue 3, 2004, Pages 523-534

  Riffel, Kerry A ^a   Polinko, Michelle A ^a   Song, Hengchang ^a   Rippley, Ronda K ^a   Lo, Man Wai ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Insulin sensitizer; Liquid liquid extraction; Negative ion LC MS MS; PPAR

Indexed keywords

5 [3 [3 (4 PHENOXY 2 PROPYLPHENOXY)PROPOXY]PHENYL] 2,3 THIAZOLIDINEDIONE SODIUM; ACETIC ACID ETHYL ESTER; ACETONITRILE; AMMONIUM ACETATE; DRUG METABOLITE; FORMIC ACID; GLASS; INSULIN SENSITIZING AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; POLYPROPYLENE; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MONITORING; PLASMA; PRIORITY JOURNAL; REPRODUCIBILITY; SEPARATION TECHNIQUE; STANDARD;

GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYDROXYLATION; INSULIN; TECHNOLOGY, PHARMACEUTICAL; THIAZOLIDINEDIONES;

EID: 2342612804     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2004.01.004     Document Type: Article

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