Effects of length and amino acid sequence of O-mannosyl peptides on substrate specificity of protein O-linked mannose β1,2-N-acetylglucosaminyltransferase 1 (POMGnT1)

Biochemical and Biophysical Research Communications

Volumn 410, Issue 3, 2011, Pages 632-636

  Akasaka Manya, Keiko ^a   Manya, Hiroshi ^a   Mizuno, Mamoru ^b   Inazu, Toshiyuki ^c   Endo, Tamao ^a  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b NOGUCHI INSTITUTE   (Japan)

^c TOKAI UNIVERSITY   (Japan)

Author keywords

Baculovirus insect cell expression system; Glycosyltransferase; Kinetic analysis; POMGnT1; Substrate specificity

Indexed keywords

ALPHA DYSTROGLYCAN; MANNOSE; N ACETYLGLUCOSAMINYLTRANSFERASE; O MANNOSYL PEPTIDE; PEPTIDE DERIVATIVE; PROTEIN O LINKED MANNOSE BETA 1,2 N ACETYLGLUCOSAMINYLTRANSFERASE 1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; HUMANS; MANNOSE; MOLECULAR SEQUENCE DATA; N-ACETYLGLUCOSAMINYLTRANSFERASES; PEPTIDES; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 79960045861     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.06.042     Document Type: Article

References (11)

1. Yoshida A., Kobayashi K., Manya H., Taniguchi K., Kano H., Mizuno M., Inazu T., Mitsuhashi H., Takahashi S., Takeuchi M., Herrmann R., Straub V., Talim B., Voit T., Topaloglu H., Toda T., Endo T. Muscular dystrophy and neuronal migration disorder caused by mutations in a glycosyltransferase, POMGnT1. Dev. Cell 2001, 1:717-724.
2. Zhang W., Vajsar J., Cao P., Breningstall G., Diesen C., Dobyns W., Herrmann R., Lehesjoki A.E., Steinbrecher A., Talim B., Toda T., Topaloglu H., Voit T., Schachter H. Enzymatic diagnostic test for Muscle-Eye-Brain type congenital muscular dystrophy using commercially available reagents. Clin. Biochem. 2003, 36:339-344.
3. Luo Y., Koles K., Vorndam W., Haltiwanger R.S., Panin V.M. Protein O-fucosyltransferase 2 adds O-fucose to thrombospondin type 1 repeats. J. Biol. Chem. 2006, 281:9393-9399.
4. Luo Y., Nita-Lazar A., Haltiwanger R.S. Two distinct pathways for O-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats. J. Biol. Chem. 2006, 281:9385-9392.
5. Takahashi S., Sasaki T., Manya H., Chiba Y., Yoshida A., Mizuno M., Ishida H., Ito F., Inazu T., Kotani N., Takasaki S., Takeuchi M., Endo T. A new beta-1,2-N-acetylglucosaminyltransferase that may play a role in the biosynthesis of mammalian O-mannosyl glycans. Glycobiology 2001, 11:37-45.
6. Akasaka-Manya K., Manya H., Kobayashi K., Toda T., Endo T. Structure-function analysis of human protein O-linked mannose beta1, 2-N-acetylglucosaminyltransferase 1, POMGnT1. Biochem. Biophys. Res. Commun. 2004, 320:39-44.
7. Manya H., Suzuki T., Akasaka-Manya K., Ishida H.K., Mizuno M., Suzuki Y., Inazu T., Dohmae N., Endo T. Regulation of mammalian protein O-mannosylation: preferential amino acid sequence for O-mannose modification. J. Biol. Chem. 2007, 282:20200-20206.
8. Unligil U.M., Zhou S., Yuwaraj S., Sarkar M., Schachter H., Rini J.M. X-ray crystal structure of rabbit N-acetylglucosaminyltransferase I: catalytic mechanism and a new protein superfamily. EMBO J. 2000, 19:5269-5280.
9. Kozma K., Keusch J.J., Hegemann B., Luther K.B., Klein D., Hess D., Haltiwanger R.S., Hofsteenge J. Identification and characterization of a beta1, 3-glucosyltransferase that synthesizes the Glc-beta1,3-Fuc disaccharide on thrombospondin type 1 repeats. J. Biol. Chem. 2006, 281:36742-36751.
10. Nilsson J., Larson G., Grahn A. Characterization of site-specific O-glycan structures within the mucin-like domain of alpha-dystroglycan from human skeletal muscle. Glycobiology 2010, 20:1160-1169.
11. Stalnaker S.H., Hashmi S., Lim J.M., Aoki K., Porterfield M., Gutierrez-Sanchez G., Wheeler J., Ervasti J.M., Bergmann C., Tiemeyer M., Wells L. Site mapping and characterization of O-glycan structures on alpha-dystroglycan isolated from rabbit skeletal muscle. J. Biol. Chem. 2010, 285:24882-24891.