Inverse expression states of the BRN2 and MITF transcription factors in melanoma spheres and tumour xenografts regulate the NOTCH pathway

Oncogene

Volumn 30, Issue 27, 2011, Pages 3036-3048

  Thurber, A E ^a   Douglas, G ^a   Sturm, E C ^a   Zabierowski, S E ^b   Smit, D J ^a   Ramakrishnan, S N ^a   Hacker, E ^c   Leonard, J H ^c   Herlyn, M ^b   Sturm, R A ^a,b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b WISTAR INSTITUTE   (United States)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

cell adhesion; invasion; melanoma; metastasis; NOTCH; transcription factor

Indexed keywords

COLLAGEN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; NOTCH RECEPTOR; NOTCH1 RECEPTOR; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BRN2; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER STEM CELL; CELL ADHESION; CELL DIFFERENTIATION; CELL SUBPOPULATION; HUMAN; HUMAN CELL; MELANOMA; MONOLAYER CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SPHEROID CELL; TUMOR XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; HOMEODOMAIN PROTEINS; HUMANS; MELANOMA; MICE; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; POU DOMAIN FACTORS; RECEPTORS, NOTCH; TRANSPLANTATION, HETEROLOGOUS;

EID: 79960042271     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.33     Document Type: Article

References (36)

1. Alonso SR, Tracey L, Ortiz P, Perez-Gomez B, Palacios J, Pollan M et al. (2007). A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis. Cancer Res 67: 3450-3460. (Pubitemid 46724886)
2. Carreira S, Goodall J, Denat L, Rodriguez M, Nuciforo P, Hoek KS et al. (2006). Mitf regulation of Dia1 controls melanoma proliferation and invasiveness. Genes Dev 20: 3426-3439. (Pubitemid 44969160)
3. Castro DS, Skowronska-Krawczyk D, Armant O, Donaldson IJ, Parras C, Hunt C et al. (2006). Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif. Dev Cell 11: 831-844. (Pubitemid 44804278)
4. Cheli Y, Ohanna M, Ballotti R, Bertolotto C. (2010). Fifteen-year quest for microphthalmia-associated transcription factor target genes. Pigment Cell Melanoma Res 23: 27-40.
5. Cook AL, Boyle GM, Leonard JH, Parsons PG, Sturm RA. (2006). BRN2 in melanocytic cell development, differentiation and transformation. In: Hearing VJ and Leong SPL (eds). From Melanocytes to Melanoma. Humana Press: Totowa, New Jersey. pp 149-167.
6. Cook AL, Donatien PD, Smith AG, Murphy M, Jones MK, Herlyn M et al. (2003). Human melanoblasts in culture: expression of BRN2 and synergistic regulation by fibroblast growth factor-2, stem cell factor, and endothelin-3. J Invest Dermatol 121: 1150-1159. (Pubitemid 37430986)
7. Cook AL, Smith AG, Smit DJ, Leonard JH, Sturm RA. (2005). Co-expression of SOX9 and SOX10 during melanocytic differentiation in vitro. Exp Cell Res 308: 222-235. (Pubitemid 40984776)
8. Cook AL, Sturm RA. (2008). POU domain transcription factors: BRN2 as a regulator of melanocytic growth and tumourigenesis. Pigment Cell Melanoma Res 21: 611-626.
9. Dodd IB, Micheelsen MA, Sneppen K, Thon G. (2007). Theoretical analysis of epigenetic cell memory by nucleosome modification. Cell 129: 813-822. (Pubitemid 46802381)
10. Fang D, Nguyen TK, Leishear K, Finko R, Kulp AN, Hotz S et al. (2005). A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res 65: 9328-9337. (Pubitemid 41508000)
11. Goodall J, Carreira S, Denat L, Kobi D, Davidson I, Nuciforo P et al. (2008). Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of micro-phthalmia-associated transcription factor-negative melanoma cells. Cancer Res 68: 7788-7794.
12. Hendrix MJ, Seftor EA, Seftor RE, Kasemeier-Kulesa J, Kulesa PM, Postovit LM. (2007). Reprogramming metastatic tumour cells with embryonic microenvironments. Nat Rev Cancer 7: 246-255. (Pubitemid 46480969)
13. Hoek KS, Eichhoff OM, Schlegel NC, Dobbeling U, Kobert N, Schaerer L et al. (2008). In vivo switching of human melanoma cells between proliferative and invasive states. Cancer Res 68: 650-656. (Pubitemid 351206739)
14. Hoek KS, Goding CR. (2010). Cancer stem cells versus phenotype-switching in melanoma. Pigment Cell Melanoma Res 23: 746-759.
15. Houghton AN, Real FX, Davis LJ, Cordon-Cardo C, Old LJ. (1987). Phenotypic heterogeneity of melanoma. Relation to the differentiation program of melanoma cells. J Exp Med 165: 812-829. (Pubitemid 17059455)
16. Johansson P, Pavey S, Hayward N. (2007). Confirmation of a BRAF mutation-associated gene expression signature in melanoma. Pigment Cell Res 20: 216-221. (Pubitemid 46776377)
17. Kobi D, Steunou AL, Dembele D, Legras S, Larue L, Nieto L et al. (2010). Genome-wide analysis of POU3F2/BRN2 promoter occupancy in human melanoma cells reveals Kitl as a novel regulated target gene. Pigment Cell Melanoma Res 23: 404-418.
18. Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY et al. (2008). The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133: 704-715. (Pubitemid 351636299)
19. Miller AJ, Mihm Jr MC. (2006). Melanoma. N Engl J Med 355: 51-65.
20. Mouriaux F, Vincent S, Kherrouche Z, Maurage CA, Planque N, Monte D et al. (2003). Microphthalmia transcription factor analysis in posterior uveal melanomas. Exp Eye Res 76: 653-661. (Pubitemid 36549022)
21. Na YR, Seok SH, Kim DJ, Han JH, Kim TH, Jung H et al. (2009a). Isolation and characterization of spheroid cells from human malignant melanoma cell line WM-266-4. Tumour Biol 30: 300-309.
22. Na YR, Seok SH, Kim DJ, Han JH, Kim TH, Jung H et al. (2009b). Zebrafish embryo extracts promote sphere-forming abilities of human melanoma cell line. Cancer Sci 100: 1429-1433.
23. Newton RA, Cook AL, Roberts DW, Leonard JH, Sturm RA. (2007). Post-transcriptional regulation of melanin biosynthetic enzymes by cAMP and resveratrol in human melanocytes. J Invest Dermatol 127: 2216-2227. (Pubitemid 47258483)
24. Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW. (2008). Immunohistochemical characteristics of melanoma. J Cutan Pathol 35: 433-444. (Pubitemid 351519417)
25. Pavey S, Johansson P, Packer L, Taylor J, Stark M, Pollock PM et al. (2004). Microarray expression profiling in melanoma reveals a BRAF mutation signature. Oncogene 23: 4060-4067. (Pubitemid 38747936)
26. Perego M, Tortoreto M, Tragni G, Mariani L, Deho P, Carbone A et al. (2010). Heterogeneous phenotype of human melanoma cells with in vitro and in vivo features of tumor-initiating cells. J Invest Dermatol 130: 1877-1886.
27. Pinner S, Jordan P, Sharrock K, Bazley L, Collinson L, Marais R et al. (2009). Intravital imaging reveals transient changes in pigment production and Brn2 expression during metastatic melanoma dissemination. Cancer Res 69: 7969-7977.
28. Pinnix CC, Herlyn M. (2007). The many faces of Notch signaling in skin-derived cells. Pigment Cell Res 20: 458-465. (Pubitemid 47568831)
29. Pinnix CC, Lee JT, Liu ZJ, McDaid R, Balint K, Beverly LJ et al. (2009). Active Notch1 confers a transformed phenotype to primary human melanocytes. Cancer Res 69: 5312-5320.
30. Quintana E, Shackleton M, Sabel MS, Fullen DR, Johnson TM, Morrison SJ. (2008). Efficient tumour formation by single human melanoma cells. Nature 456: 593-598.
31. Richmond-Sinclair NM, Lee E, Cummings MC, Williamson R, Muller K, Green AC et al. (2008). Histologic and epidemiologic correlates of P-MAPK, Brn-2, pRb, p53, and p16 immunostaining in cutaneous melanomas. Melanoma Res 18: 336-345.
32. Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M et al. (2008). Identification of cells initiating human melanomas. Nature 451: 345-349.
33. Smalley KS, Haass NK, Brafford PA, Lioni M, Flaherty KT, Herlyn M. (2006). Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases. Mol Cancer Ther 5: 1136-1144. (Pubitemid 43881305)
34. Smit DJ, Gardiner BB, Sturm RA. (2007). Osteonectin downregulates E-cadherin, induces osteopontin and focal adhesion kinase activity stimulating an invasive melanoma phenotype. Int J Cancer 121: 2653-2660. (Pubitemid 350136408)
35. Smith AG, Brightwell G, Smit SE, Parsons PG, Sturm RA. (1998). Redox regulation of Brn-2/N-Oct-3 POU domain DNA binding activity and proteolytic formation of N-Oct-5 during melanoma cell nuclear extraction. Melanoma Res 8: 2-10. (Pubitemid 28114295)
36. Thomson JAF, Murphy K, Baker E, Sutherland GR, Parsons PG, Sturm RA. (1995). The brn-2 gene regulates the melanocytic phenotype and tumorigenic potential of human melanoma cells. Oncogene 11: 691-700.