Intratympanic dexamethasone/hyaluronic acid mix as an adjunct to intravenous steroid and vasoactive treatment in patients with severe idiopathic sudden sensorineural hearing loss

Otology and Neurotology

Volumn 32, Issue 5, 2011, Pages 756-760

  Gouveris, Haralampos ^a   Schuler Schmidt, Wiebke ^a   Mewes, Torsten ^a   Mann, Wolf ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Dexamethasone; Hearing loss; Hyaluronic; Intratympanic; Intravenous; Sensorineural

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID; HYALURONIC ACID; STEROID;

ADULT; ARTICLE; EARDRUM; FEMALE; HUMAN; INJECTION; INTRAVENOUS DRUG ADMINISTRATION; MALE; PERCEPTION DEAFNESS; PURE TONE AUDIOMETRY; RETROSPECTIVE STUDY; SUDDEN DEAFNESS; TREATMENT OUTCOME;

ADULT; AUDIOMETRY, PURE-TONE; DEXAMETHASONE; FEMALE; GLUCOCORTICOIDS; HEARING LOSS, SENSORINEURAL; HEARING LOSS, SUDDEN; HUMANS; HYALURONIC ACID; INJECTIONS; INJECTIONS, INTRAVENOUS; MALE; RETROSPECTIVE STUDIES; STEROIDS; TREATMENT OUTCOME; TYMPANIC MEMBRANE;

EID: 79960025373     PISSN: 15317129     EISSN: 15374505     Source Type: Journal    
DOI: 10.1097/MAO.0b013e31821a3fc3     Document Type: Article

References (18)

1. Merchant SN, Durand ML, Adams JC. Sudden deafness: is it viral? ORL J Otorhinolaryngol Relat Spec 2008;70:52-60. (Pubitemid 351196115)
2. Aimoni C, Bianchini C, Borin M, et al. Diabetes, cardiovascular risk factors and idiopathic sudden sensorineural hearing loss: a case-control study. Audiol Neurootol 2010;15:111-5.
3. Hong SM, Park CH, Lee JH. Hearing outcomes of daily intra-tympanic dexamethasone alone as a primary treatment modality for ISSHL. Otolaryngol HeadNeck Surg 2009;141:579-83.
4. Ho HG, Lin HC, Shu MT, Yang CC, Tsai HT. Effectiveness of intratympanic dexamethasone injection in sudden-deafness patients as salvage treatment. Laryngoscope 2004;114:1184-9.
5. Banerjee A, Parnes LS. Intratympanic corticosteroids for sudden idiopathic sensorineural hearing loss. Otol Neurotol 2005;26: 878-81. (Pubitemid 41330701)
6. Gouveris H, Selivanova O, Mann W. Intratympanic dexamethasone with hyaluronic acid in the treatment of idiopathic sudden sensori-neural hearing loss after failure of intravenous steroid and vasoactive therapy. EurArch Otorhinolaryngol2005;262:131-4. (Pubitemid 40386323)
7. Selivanova OA, Gouveris H, Victor A, Amedee RG, Mann W. Intratympanic dexamethasone and hyaluronic acid in patients with low-frequency and Ménière's-associated sudden sensorineural hear-ing loss. OtolNeurotol 2005;26:890-5. (Pubitemid 41330703)
8. Chandrasekhar SS. Intratympanic dexamethasone for sudden sen-sorineural hearing loss: clinical and laboratory evaluation. Otol Neurotol 2001;22:18-23. (Pubitemid 32182848)
9. Hargunani CA, Kempton JB, DeGagne JM, Trune DR. Intratympanic injection of dexamethasone: time course of inner ear distribution and conversion to its active form OtolNeurotol 2006;27:564-9.
10. Plontke SK, Biegner T, Kammerer B, Delabar U, Salt AN. Dex-amethasone concentration gradients along scala tympani after ap-plication to the round window membrane. Otol Neurotol 2008; 29:401-6. (Pubitemid 351450804)
11. Ziegler EA, Hohlweg-Majert B, Maurer J, Mann WJ. Epidemiological data of patients with sudden hearing loss-a retrospective study over a period of three years [in German]. Laryngorhinootologie 2003;82:4-8. (Pubitemid 36182098)
12. Selivanova O, Maurer J, Ecke U, Mann WJ. The effects of Streptolysin-O and sodium hyaluronate on the permeability of the round window membrane in guinea pigs-an electrophysiologic study [in German]. Laryngorhinootologie 2003;82:235-9. (Pubitemid 36740986)
13. Bird PA, Begg EJ, Zhang M, Keast AT, Murray DP, Balkany TJ. Intratympanic versus intravenous delivery ofmethylprednisolone to cochlear perilymph. Otol Neurotol 2007;28:1124-30. (Pubitemid 350191089)
14. Borden RC, Saunders JE, Berryhill WE, Krempl GA, Thompson DM, Queimado L. Hyaluronic acid hydrogel sustains the delivery of dexamethasone across the round window membrane. Audiol Neurootol 2010;16:1-■11. [Epub aheadofprint].
15. Yoshioka M, Naganawa S, Sone M, Nakata S, Teranishi M, Nakashima T. Individual differences in the permeability of the round window: evaluating the movement of intratympanic gadoli-nium into the inner ear. Otol Neurotol 2009;30:645-8.
16. Ahn JH, Yoo MH, Yoon TH, Chung JW. Can intratympanic dex-amethasone added to systemic steroids improve hearing outcome in patients with sudden deafness? Laryngoscope 2008;118:279-82. (Pubitemid 351640202)
17. Gouveris H, Mewes T, Maurer J, Mann W. Steroid and vasoactive treatment for acute deafness after attempted hearing preservation acoustic neuroma surgery. ORL J Otorhinolaryngol Relat Spec 2005;67:30-3. (Pubitemid 41201516)
18. Battista RA. Intratympanic dexamethasone for profound idiopathic sudden sensorineural hearing loss. Otolaryngol Head Neck Surg 2005;132:902-5. (Pubitemid 40798414)