Progressive multifocal leukoencephalopathy in an HIV patient receiving successful long-term HAART

Journal of NeuroVirology

Volumn 17, Issue 2, 2011, Pages 196-199

  Mascarello, Marta ^a   Lanzafame, Massimiliano ^a   Lattuada, Emanuela ^a   Concia, Ercole ^a   Ferrari, Sergio ^a  

^a UNIVERSITY OF VERONA   (Italy)

Author keywords

HAART; HIV; JC virus; Progressive multifocal leukoencephalopathy

Indexed keywords

ABACAVIR; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; LAMIVUDINE; STEROID; VIRUS DNA; ZIDOVUDINE;

ADULT; ARTICLE; AUTOPSY; BRAIN STEM; CASE REPORT; CD4 LYMPHOCYTE COUNT; CEREBROSPINAL FLUID ANALYSIS; DISEASE ASSOCIATION; DISEASE COURSE; ELECTRON MICROSCOPY; FEMALE; FOCAL EPILEPSY; FRONTAL LOBE; HEMIANOPIA; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HISTOPATHOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HYPERREFLEXIA; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; JC VIRUS; LIMB WEAKNESS; LONG TERM CARE; NEUROIMAGING; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PARIETAL LOBE; PNEUMONIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; STEROID THERAPY; TEMPORAL LOBE; ULTRASTRUCTURE; VIRUS LOAD; WHITE MATTER;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANTI-RETROVIRAL AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BRAIN; CD4 LYMPHOCYTE COUNT; DNA, VIRAL; FEMALE; HIV; HUMANS; IMMUNOSUPPRESSION; ITALY; JC VIRUS; LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL; MAGNETIC RESONANCE IMAGING; MIDDLE AGED; VIRAL LOAD;

JC POLYOMAVIRUS;

EID: 79960012674     PISSN: 13550284     EISSN: 15382443     Source Type: Journal    
DOI: 10.1007/s13365-011-0020-y     Document Type: Article

References (13)

1. Berger JR (2009) Steroids for PML-IRIS: a double-edge sword? Neurology 72(17):1454-1455
2. Berger JR, Levy RM, Flomenhoft D, Dobbs M (1998) Predictive factors for prolonged survival in acquired immunodeficiency syndrome-associated progressive multifocal leukoencephalopathy. Ann Neurol 44(3):341-349 (Pubitemid 28421438)
3. Cinque P, Bossolasco S, Brambilla AM, Boschini A, Mussini C, Pierotti C, Campi A, Casari S, Bertelli D, Mena M, Lazzarin A (2003) The effect of highly active antiretroviral therapy-induced immune reconstitution on development and outcome of progressive multifocal leukoencephalopathy: study of 43 cases with review of the literature. J Neurovirol 9(1):73-80 (Pubitemid 36656475)
4. Cinque P, Koralnik IJ, Gerevini S, Miro JM, Price RW (2009) Progressive multifocal leukoencephalopathy in HIV-1 infection. Lancet Infect Dis 9:625-636
5. Du Pasquier RA, Kuroda MJ, Zheng Y, Jean-Jacques J, Letvin NL, Koralnik IJ (2004) A prospective study demostrates an association between JC virus-specific cytotoxic T lymphocytes and the early control of progressive multifocal leukoencephalopathy. Brain 127:1970-1978 (Pubitemid 39150256)
6. Falcò V, Olmo M, Villar del Saz S, Guelar A, Santos JR, Gutiérrez M, Colomer D, Deig E, Mateo G, Montero M, Pedrol E, Podzamczer D, Domingo P, Llibre JM (2008) Influence of HAART on the clinical course of HIV-1-infected patients with progressive multifocal leukoencephalopathy: results of an observational multicenter study. J Acquir Immune Defic Syndr 49(1):26-31
7. Ferrante P, Caldarelli-Stefano R, Omodeo-Zorini E, Vago L, Boldorini R, Costanzi G (1995) PCR detection of JC virus DNA in brain tissue from patients with and without progressive multifocal leukoencephalopathy. J Med Virol 47:219-225
8. Ferrari S, Monaco S, Morbin M, Zanusso G, Bertolasi L, Cerini R, Rizzuto N (1998) HIV associated PML presenting as epilepsia partialis continua. J Neurol Sci 161(2):180-184 (Pubitemid 28559174)
9. Gheuens S, Pierone G, Peeters P, Koralnik IJ (2010) Progressive multifocal leukoencephalopathy in individuals with minimal or occult immunosuppression. J Neurol Neurosurg Psychiatry 81:247-254
10. Khanna N, Elzi L, Mueller NJ, Garzoni C, Cavassini M, Fux CA, Vernazza P, Bernasconi E, Battegay M, Hirsch HH, Swiss HIV Cohort Study (2009a) Incidence and outcome of progressive multifocal leukoencephalopathy over 20 years of the Swiss HIV Cohort Study. Clin Infect Dis 48:1459-1466
11. Khanna N, Wolbers M, Mueller NJ, Garzoni C, Du Pasquier R, Fux CA, Vernazza P, Bernasconi E, Viscidi R, Battegay M, Hirsch HH, Swiss HIV Cohort Study (2009b) JC virus-specific immune responses in human immunodeficiency virus type 1 patients with progressive multifocal leukoencephalopathy. J Virol 83(9):4404-4411
12. Tan CS, Koralnik IJ (2010) Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis. Lancet Neurol 9(4):425-437
13. Tantisiriwat W, Tebas P, Clifford DB, Powderly WG, Fichtenbaum CJ (1999) Progressive multifocal leukoencephalopathy in patients with AIDS receiving highly active antiretroviral therapy. Clin Infect Dis 28(5):1152-1154 (Pubitemid 29203555)