Analgesic effects of EMLA cream and oral sucrose during venipuncture in preterm infants

Pediatrics

Volumn 128, Issue 1, 2011, Pages

  Biran, Valérie ^a,b,c   Gourrier, Elisabeth ^d   Cimerman, Patricia ^a   Walter Nicolet, Elizabeth ^a   Mitanchez, Delphine ^a   Carbajal, Ricardo ^a,b  

^a ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^b INSERM   (France)

^c PremUP   (France)

^d CENTRE HOSPITALIER DE MEAUX   (France)

Author keywords

DAN; EMLA; Pain; PIPP; Preterm; Sucrose; Venipuncture

Indexed keywords

DEXPANTHENOL; EMLA; PLACEBO; SUCROSE;

ANALGESIC ACTIVITY; ANALYSIS OF VARIANCE; ARTICLE; BEHAVIOR; BLANCHING; BLOOD SAMPLING; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG SAFETY; ERYTHEMA; FACIAL EXPRESSION; FEMALE; GESTATIONAL AGE; HEART RATE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; NEWBORN; NEWBORN CARE; OXYGEN SATURATION; PAIN ASSESSMENT; PREMATURITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; VEIN PUNCTURE;

ADMINISTRATION, ORAL; ANALGESIA; ANESTHETICS, LOCAL; DOSAGE FORMS; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; LIDOCAINE; PAIN; PHLEBOTOMY; PRILOCAINE; PROSPECTIVE STUDIES; SUCROSE;

EID: 79960004402     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2010-1287     Document Type: Article

References (41)

1. Anand KJ, Hickey PR. Pain and its effects in the human neonate and fetus. N Engl J Med. 1987;317(21):1321-1329
2. Porter FL, Grunau RE, Anand KJ. Long-term effects of pain in infants. J Dev Behav Pediatr. 1999;20(4):253-261
3. Taddio A, Katz J, Ilersich AL, Koren G. Effect of neonatal circumcision on pain response during subsequent routine vaccination. Lancet. 1997;349(9052):599-603 (Pubitemid 27101886)
4. Grunau RE, Holsti L, Peters JW. Long-term consequences of pain in human neonates. Semin Fetal Neonatal Med. 2006;11(4):268-275 (Pubitemid 43794847)
5. Anand KJ, International Evidence-Based Group for Neonatal Pain. Consensus statement for the prevention and management of pain in the newborn. Arch Pediatr Adolesc Med. 2001;155(2):173-180 (Pubitemid 32128388)
6. Prevention and management of pain and stress in the neonate. American Academy of Pediatrics. Committee on Fetus and Newborn. Committee on Drugs. Section on Anesthesiology. Section on Surgery. Canadian Paediatric Society. Fetus and Newborn Committee. Pediatrics. 2000;105(2):454-461
7. Shah VS, Taddio A, Bennett S, Speidel BD. Neonatal pain response to heel stick vs venepuncture for routine blood sampling. Arch Dis Child Fetal Neonatal Ed. 1997;77(2):F143-F144 (Pubitemid 28201611)
8. Larsson BA, Tannfeldt G, Lagercrantz H, Olsson GL. Venipuncture is more effective and less painful than heel lancing for blood tests in neonates. Pediatrics. 1998;101(5):882-886 (Pubitemid 28204841)
9. Johnston CC, Stremler R, Horton L, Friedman A. Effect of repeated doses of sucrose during heel stick procedure in preterm neonates. Biol Neonate. 1999;75(3):160-166 (Pubitemid 29067299)
10. Skogsdal Y, Eriksson M, Schollin J. Analgesia in newborns given oral glucose. Acta Paediatr. 1997;86(2):217-220 (Pubitemid 27086779)
11. Stevens B, Yamada J, Ohlsson A. Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst Rev. 2010;(1):CD001069
12. Taddio A, Shah V, Hancock R, et al. Effectiveness of sucrose analgesia in newborns undergoing painful medical procedures. CMAJ. 2008;179(1):37-43 (Pubitemid 351969810)
13. Taddio A, Shah V, Atenafu E, Katz J. Influence of repeated painful procedures and sucrose analgesia on the development of hyperalgesia in newborn infants. Pain. 2009;144(1-2):43-48
14. Barr RG, Quek VS, Cousineau D, Oberlander TF, Brian JA, Young SN. Effects of intra-oral sucrose on crying, mouthing and handmouth contact in newborn and six-week-old infants. Dev Med Child Neurol. 1994;36(7):608-618 (Pubitemid 24182767)
15. Taddio A, Shennan AT, Stevens B, Leeder JS, Koren G. Safety of lidocaine-prilocaine cream in the treatment of preterm neonates. J Pediatr. 1995;127(6):1002-1005 (Pubitemid 26003303)
16. Gourrier E, Karoubi P, el Hanache A, Merbouche S, Mouchnino G, Leraillez J. Use of EMLA cream in a department of neonatology. Pain. 1996;68(2-3):431-434 (Pubitemid 27025903)
17. Larsson BA, Tannfeldt G, Lagercrantz H, Olsson GL. Alleviation of the pain of venepuncture in neonates. Acta Paediatr. 1998;87(7):774-779 (Pubitemid 28346082)
18. Lindh V, Wiklund U, Håkansson S. Assessment of the effect of EMLA during venipuncture in the newborn by analysis of heart rate variability. Pain. 2000;86(3):247-254 (Pubitemid 30254265)
19. Acharya AB, Bustani PC, Phillips JD, Taub NA, Beattie RM. Randomised controlled trial of eutectic mixture of local anaesthetics cream for venepuncture in healthy preterm infants. Arch Dis Child Fetal Neonatal Ed. 1998;78(2):F138-F142 (Pubitemid 28201563)
20. Carbajal R, Veerapen S, Couderc S, Jugie M, Ville Y. Analgesic effect of breast feeding in term neonates: randomised controlled trial. BMJ. 2003;326(7379):13
21. Carbajal R, Rousset A, Danan C, et al. Epidemiology and treatment of painful procedures in neonates in intensive care units. JAMA. 2008;300(1):60-70 (Pubitemid 351920405)
22. Carbajal R, Maclart E. Application of EMLA cream without an adhesive film [in French]. Arch Pediatr. 1997;4(4):84-85
23. Prechtl HF. The behavioural states of the newborn infant (a review). Brain Res. 1974;76(2):185-212
24. Carbajal R, Paupe A, Hoenn E, Lenclen R, Olivier-Martin M. APN: evaluation behavioral scale of acute pain in newborn infants [in French]. Arch Pediatr. 1997;4(7):623-628 (Pubitemid 27287262)
25. Stevens B, Johnston C, Petryshen P, Taddio A. Premature Infant Pain Profile: development and initial validation. Clin J Pain. 1996;12(1):13-22 (Pubitemid 26128581)
26. Lefrak L, Burch K, Caravantes R, et al. Sucrose analgesia: identifying potentially better practices. Pediatrics. 2006;118(suppl 2):S197-S202 (Pubitemid 46397636)
27. Powell CV, Kelly AM, Williams A. Determining the minimum clinically significant difference in visual analog pain score for children. Ann Emerg Med. 2001;37(1):28-31 (Pubitemid 32066336)
28. Gradin M, Eriksson M, Holmqvist G, Holstein A, Schollin J. Pain reduction at venipuncture in newborns: oral glucose compared with local anesthetic cream. Pediatrics. 2002;110(6):1053-1057 (Pubitemid 35425177)
29. Gourrier E, Karoubi P, el Hanache A, et al. Use of EMLA cream in premature and fullterm newborn infants. Study of efficacy and tolerance [in French]. Arch Pediatr. 1995;2(11):1041-1046
30. Brisman M, Ljung BM, Otterbom I, Larsson LE, Andréasson SE. Methaemoglobin formation after the use of EMLA cream in term neonates. Acta Paediatr. 1998;87(11):1191-1194 (Pubitemid 28538431)
31. Lander J, Brady-Fryer B, Metcalfe JB, Nazarali S, Muttitt S. Comparison of ring block, dorsal penile nerve block, and topical anesthesia for neonatal circumcision: a randomized controlled trial. JAMA. 1997;278(24):2157-2162 (Pubitemid 28013489)
32. Law RM, Halpern S, Martins RF, Reich H, Innanen V, Ohlsson A. Measurement of methemoglobin after EMLA analgesia for newborn circumcision. Biol Neonate. 1996;70(4):213-217 (Pubitemid 26377482)
33. Stevens B, Johnston C, Taddio A, et al. Management of pain from heel lance with lidocaine-prilocaine (EMLA) cream: is it safe and efficacious in preterm infants? J Dev Behav Pediatr. 1999;20(4):216-221
34. Ash-Bernal R, Wise R, Wright SM. Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals. Medicine (Baltimore). 2004;83(5):265-273 (Pubitemid 39258412)
35. de Jong PC, Kansen PJ. A comparison of epidural catheters with or without subcutaneous injection ports for treatment of cancer pain. Anesth Analg. 1994;78(1):94-100 (Pubitemid 24012608)
36. Anand KJ, Aranda JV, Berde CB, et al. Summary proceedings from the neonatal paincontrol group. Pediatrics. 2006;117(3 pt 2):S9-S22 (Pubitemid 46063167)
37. Carbajal R, Chauvet X, Couderc S, Olivier-Martin M. Randomised trial of analgesic effects of sucrose, glucose, and pacifiers in term neonates. BMJ. 1999;319(7222):1393-1397
38. Blass EM, Watt LB. Suckling- and sucrose-induced analgesia in human newborns. Pain. 1999;83(3):611-623
39. Blass EM. Behavioral and physiological consequences of suckling in rat and human newborns. Acta Paediatr Suppl. 1994;397:71-76 (Pubitemid 24238984)
40. Taddio A, Ohlsson A, Einarson TR, Stevens B, Koren G. A systematic review of lidocaineprilocaine cream (EMLA) in the treatment of acute pain in neonates. Pediatrics. 1998;101(2). Available at: www.pediatrics.org/cgi/content/full/101/ 2/e1
41. Slater R, Fitzgerald M, Meek J. Can cortical responses following noxious stimulation inform us about pain processing in neonates? Semin Perinatol. 2007;31(5):298-302 (Pubitemid 47464603)