Pharmacokinetics of diazepam administered intramuscularly by autoinjector versus rectal gel in healthy subjects: A phase I, randomized, open-label, single-dose, crossover, single-centre study

Clinical Drug Investigation

Volumn 31, Issue 8, 2011, Pages 585-597

  Lamson, Michael J ^a   Sitki Green, Diane ^b   Wannarka, Gerald L ^c   Mesa, Michael ^d   Andrews, Paul ^a   Pellock, John ^e  

^a PFIZER INC   (United States)

^b UCB PHARMA   (Belgium)

^c Wannarka Consulting   (United States)

^d Meridian Medical Technologies   (United States)

^e VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Diazepam; Epilepsy; Intramuscular; Rectal.

Indexed keywords

DIAZEPAM; NORDAZEPAM;

ADULT; AREA UNDER THE CURVE; ARTICLE; AUTOINJECTOR; BIOEQUIVALENCE; BLOOD ANALYSIS; CROSSOVER PROCEDURE; DIZZINESS; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; GEL; HUMAN; HUMAN EXPERIMENT; INJECTION SITE DISCOMFORT; INJECTION SITE PAIN; INTERMETHOD COMPARISON; MALAISE; MALE; MAXIMUM PLASMA CONCENTRATION; MEDICAL APPARATUS, EQUIPMENT AND SUPPLIES; NAUSEA; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATION DEPRESSION; TACHYCARDIA; TIME TO MAXIMUM PLASMA CONCENTRATION; VITAL SIGN; VOMITING;

ADMINISTRATION, RECTAL; ADULT; ANTICONVULSANTS; AREA UNDER CURVE; CROSS-OVER STUDIES; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INJECTIONS, INTRAMUSCULAR; MALE; NORDAZEPAM; YOUNG ADULT;

EID: 79959999087     PISSN: 11732563     EISSN: 11791918     Source Type: Journal    
DOI: 10.2165/11590250-000000000-00000     Document Type: Article

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