Pivotal role of glutathione depletion in plasma-induced endothelial oxidative stress during sepsis

Critical Care Medicine

Volumn 36, Issue 8, 2008, Pages 2328-2334

  Huet, Olivier ^a,b,c   Cherreau, Christaine ^c   Nicco, Carole ^c   Dupic, Laurent ^b,c   Conti, Marc ^b   Borderie, Didier ^a,b   Pene, Frédéric ^c   Vicaut, Eric ^c   Benhamou, Dan ^c   Mira, Jean Paul ^c   Duranteau, Jacques ^a,b   Batteux, Frédéric ^c  

^a BICÊTRE HOSPITAL   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

Author keywords

Endothelial cells; Glutathione; Oxidative stress; Reactive oxygen species; Sepsis

Indexed keywords

ACETYLCYSTEINE; CATALASE; DICHLORODIHYDROFLUORESCEIN DIACETATE; GLUTATHIONE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; SCAVENGER;

ADULT; ARTICLE; BLOOD SAMPLING; CELL DEATH; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; HOSPITAL ADMISSION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTENSIVE CARE UNIT; MALE; MORTALITY; OBSERVATIONAL STUDY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEPTIC SHOCK; SPECTROFLUOROMETRY; UMBILICAL VEIN; UNIVERSITY HOSPITAL; AGED; APACHE; BLOOD; DRUG EFFECT; METABOLISM; MIDDLE AGED; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ACETYLCYSTEINE; ADULT; AGED; APACHE; CELL DEATH; ENDOTHELIUM, VASCULAR; FEMALE; FREE RADICAL SCAVENGERS; GLUTATHIONE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SHOCK, SEPTIC;

EID: 49949094582     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181800387     Document Type: Article

References (39)

1. Childs EW, Udobi KF, Wood JG, et al: In vivo visualization of reactive oxidants and leukocyte-endothelial adherence following hemorrhagic shock. Shock 2002; 18:423-427
2. Ince C: Microcirculation in distress: A new resuscitation end point? Crit Care Med 2004; 32:1963-1964
3. Goldman D, Bateman RM, Ellis CG: Effect of sepsis on skeletal muscle oxygen consumption and tissue oxygenation: Interpreting capillary oxygen transport data using a mathematical model. Am J Physiol Heart Circ Physiol 2004; 287:H2535-H2544
4. Aird WC: The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 2003; 101:3765-3777
5. Godin C, Caprani A, Dufaux J, et al: Interactions between neutrophils and endothelial cells. J Cell Sci 1993; 106 (Pt 2):441-451
6. Droge W: Free radicals in the physiological control of cell function. Physiol Rev 2002; 82:47-95
7. Peters K, Unger RE, Brunner J, et al: Molecular basis of endothelial dysfunction in sepsis. Cardiovasc Res 2003; 60:49-57
8. Huet O, Obata R, Aubron C, et al: Plasmainduced endothelial oxidative stress is related to the severity of septic shock. Crit Care Med 2007; 35:821-826
9. Goode HF, Cowley HC, Walker BE, et al: Decreased antioxidant status and increased lipid peroxidation in patients with septic shock and secondary organ dysfunction. Crit Care Med 1995; 23:646-651
10. Corda S, Laplace C, Vicaut E, et al: Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by cer-amide. Am J Respir Cell Mol Biol 2001; 24: 762-768
11. Goossens V, Grooten J, De Vos K, et al: Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity. Proc Natl Acad Sci USA 1995; 92:8115-8119
12. 2. J Clin Invest 1992; 89:794-802
13. Hayter HL, Pettus BJ, Ito F, et al: TNFalpha induced glutathione depletion lies downstream of cPLA(2) in L929 cells. FEBS Lett 2001; 507:151-156
14. Bone RC, Balk RA, Cerra FB, et al: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101:1644-1655
15. Dellinger RP, Carlet JM, Masur H, et al: Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004; 32:858-873
16. Chanseaud Y, Garcia de la Pena-Lefebvre P, Guilpain P, et al: IgM and IgG autoantibodies from microscopic polyangiitis patients but not those with other small- and medium-sized vessel vasculitides recognize multiple endothelial cell antigens. Clin Immunol 2003; 109:165-178
17. Beauchamp C, Fridovich I: Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem 1971; 44:276-287
18. Aebi H: Catalase in vitro. Methods Enzymol 1984; 105:121-126
19. Bellomo G, Palladini G, Vairetti M: Intranuclear distribution, function and fate of glutathione and glutathione-S-conjugate in living rat hepatocytes studied by fluorescence microscopy. Microsc Res Tech 1997; 36: 243-252
20. De Flora S, Bennicelli C, Camoirano A, et al: In vivo effects of N-acetylcysteine on glutathione metabolism and on the biotransformation of carcinogenic and/or mutagenic compounds. Carcinogenesis 1985; 6:1735-1745
21. De Vries N, De Flora S: N-acetyl-L-cysteine. J Cell Biochem Suppl 1993; 17F:270-277
22. Alexandre J, Batteux F, Nicco C, et al: Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo. Int J Cancer 2006; 119:41-48
23. Laurent A, Nicco C, Chereau C, et al: Controlling tumor growth by modulating endogenous production of reactive oxygen species. Cancer Res 2005; 65:948-956
24. Laurent A, Nicco C, Tran Van Nhieu J, et al: Pivotal role of superoxide anion and beneficial effect of antioxidant molecules in murine steatohepatitis. Hepatology 2004; 39: 1277-1285
25. Wosikowski K, Kung W, Hasmann M, et al: Inhibition of growth-factor-activated proliferation by anti-estrogens and effects on early gene expression of MCF-7 cells. Int J Cancer 1993; 53:290-297
26. Filep JG: Septic plasma-induced oxidative stress in endothelial cells: A sensitive bioassay predicting outcome in septic shock? Crit Care Med 2007; 35:967-968
27. Rahman I, MacNee W: Oxidative stress and regulation of glutathione in lung inflammation. Eur Respir J 2000; 16:534-554
28. Rahman I, MacNee W: Regulation of redox glutathione levels and gene transcription in lung inflammation: Therapeutic approaches. Free Radic Biol Med 2000; 28:1405-1420
29. Rahman I, Antonicelli F, MacNee W: Molecular mechanism of the regulation of gluta- thione synthesis by tumor necrosis factor-alpha and dexamethasone in human alveolar epithelial cells. J Biol Chem 1999; 274: 5088-5096
30. Urata Y, Yamamoto H, Goto S, et al: Long exposure to high glucose concentration impairs the responsive expression of gamma-glutamylcysteine synthetase by interleukin-1beta and tumor necrosis factor-alpha in mouse endothelial cells. J Biol Chem 1996; 271:15146-15152
31. Kakkar R, Mantha SV, Radhi J, et al: Antioxidant defense system in diabetic kidney: A time course study. Life Sci 1997; 60:667-679
32. Andrades M, Ritter C, Moreira JC, et al: Ox-idative parameters differences during non-lethal and lethal sepsis development. J Surg Res 2005; 125:68-72
33. De Chiara B, Mafrici A, Campolo J, et al: Low plasma glutathione levels after reperfused acute myocardial infarction are associated with late cardiac events. Coron Artery Dis 2007; 18:77-82
34. Kretzschmar M, Pfeiffer L, Schmidt C, et al: Plasma levels of glutathione, alpha-toco-pherol and lipid peroxides in polytrauma-tized patients; evidence for a stimulating effect of TNF alpha on glutathione synthesis. Exp Toxicol Pathol 1998; 50(4-6):477-483
35. Paterson RL, Galley HF, Webster NR: The effect of N-acetylcysteine on nuclear factor-kappa B activation, interleukin-6, interleukin-8, and intercellular adhesion molecule-1 expression in patients with sepsis. Crit Care Med 2003; 31:2574-2578
36. Spapen H, Zhang H, Demanet C, et al: Does N-acetyl-L-cysteine influence cytokine response during early human septic shock? Chest 1998; 113:1616-1624
37. Ortolani O, Conti A, De Gaudio AR, et al: The effect of glutathione and N-acetylcysteine on lipoperoxidative damage in patients with early septic shock. Am J Respir Crit Care Med 2000; 161:1907-1911
38. Rank N, Michel C, Haertel C, et al: N-ace-tylcysteine increases liver Blood flow and improves liver function in septic shock patients: results of a prospective, randomized, double-blind study. Crit Care Med 2000; 28:3799-3807
39. Hein OV, Ohring R, Schilling A, et al: N-ace-tylcysteine decreases lactate signal intensities in liver tissue and improves liver function in septic shock patients, as shown by magnetic resonance spectroscopy: Extended case report. Crit Care 2004; 8:R66-R71