Immunohistochemical characterization of sonic hedgehog and its downstream signaling molecules during human penile development

Fetal and Pediatric Pathology

Volumn 30, Issue 4, 2011, Pages 244-251

  Shehata, Bahig M ^a,b   Elmore, James M ^b   Bootwala, Yasmin ^a   Steelman, Charlotte K ^a,b   Bare, Jessica B ^b   Shoffeitt, Carla J ^b   Wang, Ruoxiang ^a   Zhau, Haiyen E ^a   He, Dalin ^c   Zhu, Guodong ^c   Chung, Leland W ^b  

^a EMORY UNIVERSITY   (United States)

^b CHILDREN'S HEALTHCARE OF ATLANTA   (United States)

^c XI'AN MEDICAL UNIVERSITY   (China)

Author keywords

Gli; Human; Immunohistochemistry; Patched; Penis; Smoothened; Sonic Hedgehog (Shh)

Indexed keywords

PROTEIN PATCHED 1; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

ARTICLE; CLINICAL ARTICLE; FETUS; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; HYPOSPADIAS; IMMUNOHISTOCHEMISTRY; MALE; ORGANOGENESIS; PENIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION; URETHRA; UROTHELIUM;

ANIMALS; FEMALE; FETUS; GESTATIONAL AGE; HEDGEHOG PROTEINS; HUMANS; HYPOSPADIAS; IMMUNOHISTOCHEMISTRY; MALE; ORGANOGENESIS; PENIS; PREGNANCY; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 79959985564     PISSN: 15513815     EISSN: 15513823     Source Type: Journal    
DOI: 10.3109/15513815.2011.555809     Document Type: Article

References (27)

1. Gallentine ML, Morey AF, Thompson IM, Jr. Hypospadias: A contemporary epidemiologic assessment. Urology 57(4):788-790, 2001.
2. Paulozzi LJ, Erickson JD, Jackson RJ. Hypospadias trends in two US surveillance systems. Pediatrics 100(5):831-834, 1997. (Pubitemid 27463319)
3. Byars LT. A technique for consistently satisfactory repair of hypospadias. Surg Gynecol Obstet 100(2):184-190, 1995.
4. Desprez JD, Persky L, Kiehn CL. One-stage repair of hypospadias by island flap technique. Plast Reconstr Surg 28:405-41, 1961.
5. Fuqua F. Renaissance of urethroplasty: the Belt technique of hypospadias repair. J Urol 106(5):782-785, 1971.
6. Duckett JW, Jr. Transverse preputial island flap technique for repair of severe hypospadias. Urol Clin North Am 7(2):423-430, 1980. (Pubitemid 10002777)
7. Snodgrass W, Koyle M, Manzoni G, Hurwitz R, Caldamone A, Ehrlich R. Tubularized incised plate hypospadias repair for proximal hypospadias. J Urol 159(6):2129-2131, 1998. (Pubitemid 29190794)
8. Jukier L, Kaufman M, Pinsky L, Peterson RE. Partial androgen resistance associatedwith secondary 5 alpha-reductase deficiency: identification of a novel qualitative androgen receptor defect and clinical implications. J Clin Endocrinol Metab 59(4):679-688, 1984. (Pubitemid 14012491)
9. Batch JA, Williams DM, Davies HR, Brown BD, Evans BA, Hughes IA, Patterson MN. Role of the androgen receptor inmale sexual differentiation. Horm Res 38(5-6):226-229, 1992. (Pubitemid 23185845)
10. Silver RI.What is the etiology of hypospadias? A review of recent research. DelMed J 72:343, 2000.
11. Jackson JF,Montalvo JM. Hypospadics in Klinefelter's syndrome. J Urol 1968;100(3):315-316.
12. Yucel S, Cavalcanti AG, Desouza A, Wang Z, Baskin LS. The effect of oestrogen and testosterone on the urethral seam of the developing male mouse genital tubercle. BJU Int 92(9):1016-1021, 2003. (Pubitemid 37548287)
13. Muroya K, Sasagawa I, Suzuki Y, Nakada T, Ishii T, Ogata T. Hypospadias and the androgen receptor gene: mutation screening and CAG repeat length analysis. Mol Hum Reprod 7(5):409-413, 2001. (Pubitemid 32447765)
14. Podlasek CA,Meroz CL, Korolis H, Tang Y,McKenna KE,McVary KT. Sonic hedgehog, the penis and erectile dysfunction: a review of sonic hedgehod signaling in the penis. Current Phamarceutical Design 11:4011-4027, 2005. (Pubitemid 41672473)
15. Podlasek CA, Zelner DJ, Jiang HB, Tang Y, Houston J, McKenna KE, McVary KT. Sonic hedgehog cascade is required for penile postnatal morphogenesis, differentiation, and adult homeostasis. Biol Reprod 68:423-38, 2003. (Pubitemid 36139307)
16. Podlasek CA, Barnett DH, Clemens JQ, Bak PM, Bushman W. Prostate development requires Sonic hedgehog expressed by the urogenital sinus epithelium. Dev Biology 2009:28-39, 1999.
17. Feyaerts A, Forest MG, Morel Y, Mure PY, Morel-Journel N, Mallet D, Nicolino M, Chatelain P, David M, Moriguand P. Endocrine screening in 32 consecutive patients with hypospadias. J Urol 168(2):720-725, 2002. (Pubitemid 34793350)
18. Holmes NM,Miller WL, Baskin LS. Lack of defects in androgen production in childrenwith hypospadias. J Clin Endocrinol Metab 89(6):2811-2816, 2004. (Pubitemid 38766370)
19. Podlasek CA, Zelner DJ,Harris JD,Meroz CL, Tang Y,McKenna KE,McVary KT. Altered sonic hedgehog signaling is associated with morphological abnormalities in the penis of the BB/WOR diabetic rat. Biol Reprod 69:816-827, 2003. (Pubitemid 37064609)
20. Podlasek CA, Meroz CL, Tang Y, McKenna KE, McVary KT. Regulation of cavernous nerve injuryinduced apoptosis by sonic hedgehog. Biol Reprod 76:19-28, 2007. (Pubitemid 46013443)
21. Lauger E, Nelson CE, Johnson RL,Morgan BA, Tabin C. Sonic hedgehog and Fgf-4 act through a signaling cascasde and feedback loop to integrate growth and patterning of the developing limb bud. Cell 79(6):993-1003, 1994.
22. Arsic D, Qi BQ, Beasley SW. Hedgehog in the human: A possible explanation for the VATER association. J Paediatr Child Health 38(2):117-121, 2002. (Pubitemid 34595557)
23. Perriton CL, Powles N, Chiang C, Maconochie MK, Cohn MJ. Sonic hedgehog signaling from the urethral epithelium controls external genital development. Dev Biol 247(1):26-46, 2002. (Pubitemid 34681163)
24. Haraguchi R, Mo R, Hui C, Motoyama J, Makino S, Shiroishi T, Gaffield W, Yamada G. Unique functions of sonic hedgehog signaling during external genitalia development. Development 128(21):4241-4250, 2001. (Pubitemid 33077035)
25. Yamada G, Satoh Y, Baskin LS, Cunha GR. Cellular and molecular mechanisms of development of the external genitalia. Differentiation 71(8):445-460, 2003. (Pubitemid 37363661)
26. Kim KS, Liu W, Cunha GR, Russell DW, Huang H, Shapiro E, Baskin LS. Expression of the androgen receptor and 5 alpha-reductase type 2 in the developing human fetal penis and urethra. Cell Tissue Res 307(2):145-153, 2002. (Pubitemid 34158526)
27. Oldak M, Grzela T, Lazarczyk M, Malejczyk J, Skopinski P. Clinical aspects of disrupted Hedgehog signaling (Review). Int J MolMed 8(4):445-452, 2001.