Novel splice variant CAR 4/6 of the coxsackie adenovirus receptor is differentially expressed in cervical carcinogenesis

Journal of Molecular Medicine

Volumn 89, Issue 6, 2011, Pages 621-630

  Dietel, Marit ^a   Häfner, Norman ^a   Jansen, Lars ^a   Dürst, Matthias ^a   Runnebaum, Ingo B ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

Cancer; CAR4 6; Coxsackie adenovirus receptor; Splice isoform

Indexed keywords

COMPLEMENTARY DNA; COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR; COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR 4; COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR 6; ISOPROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER GROWTH; CARCINOGENESIS; CELL ADHESION; CELL INVASION; CELL MEMBRANE; CONTROLLED STUDY; EXON; HUMAN; HUMAN TISSUE; METASTASIS; MICRODISSECTION; MOLECULAR CLONING; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA SPLICING; TIGHT JUNCTION; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA IN SITU;

CELL ADHESION; CELL LINE, TUMOR; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; HUMANS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; PROTEIN ISOFORMS; RECEPTORS, VIRUS; SEQUENCE ALIGNMENT; UTERINE CERVICAL NEOPLASMS;

EID: 79959980417     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-011-0742-6     Document Type: Article

References (38)

1. T Brummendorf V Lemmon 2001 Immunoglobulin superfamily receptors: cis-interactions, intracellular adapters and alternative splicing regulate adhesion Curr Opin Cell Biol 13 611 618 S0955-0674(00)00259-3 11544031 10.1016/S0955-0674(00)00259-3 1:CAS:528:DC%2BD3MXmsFersb0%3D (Pubitemid 32817021)
2. T Ooshio N Fujita A Yamada T Sato Y Kitagawa R Okamoto S Nakata A Miki K Irie Y Takai 2007 Cooperative roles of Par-3 and afadin in the formation of adherens and tight junctions J Cell Sci 120 2352 2365 10.1242/jcs.03470 17606991 10.1242/jcs.03470 1:CAS:528:DC%2BD2sXpslChsLg%3D (Pubitemid 47225939)
3. Y Kikkawa JH Miner 2005 Review: Lutheran/B-CAM: a laminin receptor on red blood cells and in various tissues Connect Tissue Res 46 193 199 16546822 10.1080/03008200500344074 1:CAS:528:DC%2BD28XhvFGms7c%3D
4. J Haspel M Grumet 2003 The L1CAM extracellular region: a multi-domain protein with modular and cooperative binding modes Front Biosci 8 s1210 s1225 12957823 10.2741/1108 1:CAS:528:DC%2BD3sXmt1Kju7c%3D
5. T Okegawa RC Pong Y Li JT Hsieh 2004 The role of cell adhesion molecule in cancer progression and its application in cancer therapy Acta Biochim Pol 51 445 457 15218541 1:CAS:528:DC%2BD2cXnslWjt7c%3D (Pubitemid 38969306)
6. R Fischer W Poller HP Schultheiss M Gotthardt 2009 CAR-diology-a virus receptor in the healthy and diseased heart J Mol Med 87 879 884 10.1007/s00109-009-0489-5 19495568 10.1007/s00109-009-0489-5
7. KC Huang Z Yasruel C Guerin PC Holland J Nalbantoglu 2007 Interaction of the Coxsackie and adenovirus receptor (CAR) with the cytoskeleton: binding to actin FEBS Lett 581 2702 2708 17531226 10.1016/j.febslet.2007.05.019 1:CAS:528:DC%2BD2sXmtFOiurc%3D (Pubitemid 46829115)
8. KJ Excoffon A Hruska-Hageman M Klotz GL Traver J Zabner 2004 A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth J Cell Sci 117 4401 4409 15304526 10.1242/jcs.01300 1:CAS:528:DC%2BD2cXovVehsbc%3D (Pubitemid 39360067)
9. CB Coyne T Voelker SL Pichla JM Bergelson 2004 The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction J Biol Chem 279 48079 48084 15364909 10.1074/jbc.M409061200 1:CAS:528:DC%2BD2cXptl2nsbk%3D (Pubitemid 39540961)
10. S Jiang A Jacobs TM Laue M Caffrey 2004 Solution structure of the coxsackievirus and adenovirus receptor domain 1 Biochemistry 43 1847 1853 14967025 10.1021/bi035490x 1:CAS:528:DC%2BD2cXnsVGqtA%3D%3D (Pubitemid 38233247)
11. S Jiang M Caffrey 2007 Solution structure of the coxsackievirus and adenovirus receptor domain 2 Protein Sci 16 539 542 17322536 10.1110/ps.062643507 1:CAS:528:DC%2BD2sXis1aqtrc%3D (Pubitemid 46327565)
12. KJ Excoffon GL Traver J Zabner 2005 The role of the extracellular domain in the biology of the coxsackievirus and adenovirus receptor Am J Respir Cell Mol Biol 32 498 503 15778494 10.1165/rcmb.2005-0031OC 1:CAS:528: DC%2BD2MXkvF2lurk%3D (Pubitemid 40770127)
13. P Freimuth K Springer C Berard J Hainfeld M Bewley J Flanagan 1999 Coxsackievirus and adenovirus receptor amino-terminal immunoglobulin V-related domain binds adenovirus type 2 and fiber knob from adenovirus type 12 J Virol 73 1392 1398 9882344 1:CAS:528:DyaK1MXmtlahtw%3D%3D (Pubitemid 29036794)
14. CR Bezzina R Pazoki A Bardai RF Marsman JS de Jong MT Blom BP Scicluna JW Jukema NR Bindraban P Lichtner A Pfeufer NH Bishopric DM Roden T Meitinger SS Chugh RJ Myerburg X Jouven S Kaab LR Dekker HL Tan MW Tanck AA Wilde 2010 Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction Nat Genet 42 688 691 10.1038/ng.623 20622880 10.1038/ng.623 1:CAS:528:DC%2BC3cXos1ait78%3D
15. JM Bergelson JA Cunningham G Droguett EA Kurt-Jones A Krithivas JS Hong MS Horwitz RL Crowell RW Finberg 1997 Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5 Science 275 1320 1323 9036860 10.1126/science.275.5304.1320 1:CAS:528:DyaK2sXhs1Grtbg%3D (Pubitemid 27114163)
16. RP Tomko R Xu L Philipson 1997 HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses Proc Natl Acad Sci USA 94 3352 3356 9096397 10.1073/pnas.94.7.3352 1:CAS:528:DyaK2sXisVKnsro%3D (Pubitemid 27157315)
17. JW Chen R Ghosh RW Finberg JM Bergelson 2003 Structure and chromosomal localization of the murine coxsackievirus and adenovirus receptor gene DNA Cell Biol 22 253 259 10.1089/104454903321908647 12823902 10.1089/104454903321908647 1:CAS:528:DC%2BD3sXktlantb8%3D (Pubitemid 36667853)
18. CA Shaw PC Holland M Sinnreich C Allen K Sollerbrant G Karpati J Nalbantoglu 2004 Isoform-specific expression of the coxsackie and adenovirus receptor (CAR) in neuromuscular junction and cardiac intercalated discs BMC Cell Biol 5 42 15533241 10.1186/1471-2121-5-42 (Pubitemid 39615367)
19. I Thoelen C Magnusson S Tagerud C Polacek M Lindberg M Van Ranst 2001 Identification of alternative splice products encoded by the human coxsackie-adenovirus receptor gene Biochem Biophys Res Commun 287 216 222 11549277 10.1006/bbrc.2001.5535 1:CAS:528:DC%2BD3MXms1anur4%3D (Pubitemid 32912486)
20. A Dorner D Xiong K Couch T Yajima KU Knowlton 2004 Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infection J Biol Chem 279 18497 18503 10.1074/jbc.M311754200 14978041 10.1074/jbc.M311754200 (Pubitemid 38623268)
21. E Raschperger J Thyberg S Pettersson L Philipson J Fuxe RF Pettersson 2006 The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis Exp Cell Res 312 1566 1580 16542650 10.1016/j.yexcr.2006.01. 025 1:CAS:528:DC%2BD28XktVegurw%3D
22. D Auer D Reimer V Porto M Fleischer J Roessler A Wiedemair C Marth E Muller-Holzner G Daxenbichler AG Zeimet 2009 Expression of coxsackie-adenovirus receptor is related to estrogen sensitivity in breast cancer Breast Cancer Res Treat 116 103 111 18618240 10.1007/s10549-008-0108-0 1:CAS:528: DC%2BD1MXntFaktb8%3D
23. D Reimer I Steppan A Wiedemair N Concin G Hofstetter C Marth E Muller-Holzner AG Zeimet 2007 Soluble isoforms but not the transmembrane form of coxsackie-adenovirus receptor are of clinical relevance in epithelial ovarian cancer Int J Cancer 120 2568 2575 17278108 10.1002/ijc.22580 1:CAS:528:DC%2BD2sXkslGitb0%3D (Pubitemid 46651276)
24. M Anders M Vieth C Rocken M Ebert M Pross S Gretschel PM Schlag B Wiedenmann W Kemmner M Hocker 2009 Loss of the coxsackie and adenovirus receptor contributes to gastric cancer progression Br J Cancer 100 352 359 10.1038/sj.bjc.6604876 19142187 10.1038/sj.bjc.6604876 1:CAS:528: DC%2BD1MXpsVSrsA%3D%3D
25. M Yamashita A Ino K Kawabata F Sakurai H Mizuguchi 2007 Expression of coxsackie and adenovirus receptor reduces the lung metastatic potential of murine tumor cells Int J Cancer 121 1690 1696 10.1002/ijc.22852 17546646 10.1002/ijc.22852 1:CAS:528:DC%2BD2sXhtVyktLfN (Pubitemid 47417284)
26. K Matsumoto SF Shariat GE Ayala KA Rauen SP Lerner 2005 Loss of coxsackie and adenovirus receptor expression is associated with features of aggressive bladder cancer Urology 66 441 446 10.1016/j.urology.2005.02.033 16040097 10.1016/j.urology.2005.02.033 (Pubitemid 41138121)
27. KC Huang M Altinoz K Wosik N Larochelle Z Koty L Zhu PC Holland J Nalbantoglu 2005 Impact of the coxsackie and adenovirus receptor (CAR) on glioma cell growth and invasion: requirement for the C-terminal domain Int J Cancer 113 738 745 10.1002/ijc.20623 15499626 10.1002/ijc.20623 1:CAS:528: DC%2BD2MXnvFGisA%3D%3D (Pubitemid 40101254)
28. TA Martin G Watkins WG Jiang 2005 The coxsackie-adenovirus receptor has elevated expression in human breast cancer Clin Exp Med 5 122 128 16284735 10.1007/s10238-005-0076-1 1:STN:280:DC%2BD2MngsVWksQ%3D%3D (Pubitemid 41597272)
29. WM Korn M Macal C Christian MD Lacher A McMillan KA Rauen RS Warren L Ferrell 2006 Expression of the coxsackievirus- and adenovirus receptor in gastrointestinal cancer correlates with tumor differentiation Cancer Gene Ther 13 792 797 10.1038/sj.cgt.7700947 16628228 10.1038/sj.cgt.7700947 1:CAS:528:DC%2BD28XmvFyqs7s%3D (Pubitemid 44100492)
30. MS Veena M Qin A Andersson S Sharma RK Batra 2009 CAR mediates efficient tumor engraftment of mesenchymal type lung cancer cells Lab Invest 89 875 886 19506548 10.1038/labinvest.2009.56 1:CAS:528:DC%2BD1MXpsVKmsrY%3D
31. V Wollscheid R Kuhne-Heid I Stein L Jansen S Kollner A Schneider M Durst 2002 Identification of a new proliferation-associated protein NET-1/C4.8 characteristic for a subset of high-grade cervical intraepithelial neoplasia and cervical carcinomas Int J Cancer 99 771 775 12115476 10.1002/ijc.10442 1:CAS:528:DC%2BD38XksVajsrc%3D (Pubitemid 34575692)
32. Y Wang S Wang Y Bao C Ni N Guan J Zhao LG Salford B Widegren X Fan 2006 Coxsackievirus and adenovirus receptor expression in non-malignant lung tissues and clinical lung cancers J Mol Histol 37 153 160 10.1007/s10735-006-9055-4 17031523 10.1007/s10735-006-9055-4 1:CAS:528:DC%2BD28XhtleksbjI (Pubitemid 44532065)
33. MR Schmidt B Piekos MS Cabatingan RT Woodland 2000 Expression of a human coxsackie/adenovirus receptor transgene permits adenovirus infection of primary lymphocytes J Immunol 165 4112 4119 11034423 1:CAS:528:DC%2BD3cXntVyit7w%3D (Pubitemid 32057323)
34. C Farmer PE Morton M Snippe G Santis M Parsons 2009 Coxsackie adenovirus receptor (CAR) regulates integrin function through activation of p44/42 MAPK Exp Cell Res 315 2637 2647 10.1016/j.yexcr.2009.06.008 19527712 10.1016/j.yexcr.2009.06.008 1:CAS:528:DC%2BD1MXptlSlur0%3D
35. T Okegawa RC Pong Y Li JM Bergelson AI Sagalowsky JT Hsieh 2001 The mechanism of the growth-inhibitory effect of coxsackie and adenovirus receptor (CAR) on human bladder cancer: a functional analysis of car protein structure Cancer Res 61 6592 6600 11522659 1:CAS:528:DC%2BD3MXmsF2jt78%3D (Pubitemid 32783269)
36. A Bruning IB Runnebaum 2004 The coxsackie adenovirus receptor inhibits cancer cell migration Exp Cell Res 298 624 631 10.1016/j.yexcr.2004.05.001 15265708 10.1016/j.yexcr.2004.05.001 (Pubitemid 38950877)
37. B Wang G Chen F Li J Zhou Y Lu D Ma 2005 Inhibitory effect of coxsackie adenovirus receptor on invasion and metastasis phenotype of ovarian cancer cell line SKOV3 J Huazhong Univ Sci Technolog Med Sci 25 85-87 93 1:CAS:528:DC%2BD2MXis1Cnsbw%3D
38. A Bruning E Stickeler D Diederich L Walz H Rohleder K Friese IB Runnebaum 2005 Coxsackie and adenovirus receptor promotes adenocarcinoma cell survival and is expressionally activated after transition from preneoplastic precursor lesions to invasive adenocarcinomas Clin Cancer Res 11 4316 4320 10.1158/1078-0432.CCR-04-2370 15958612 10.1158/1078-0432.CCR-04-2370 (Pubitemid 40825618)