Coxsackie and adenovirus receptor promotes adenocarcinoma cell survival and is expressionally activated after transition from preneoplastic precursor lesions to invasive adenocarcinomas

Clinical Cancer Research

Volumn 11, Issue 12, 2005, Pages 4316-4320

  Brüning, Ansgar ^a   Stickeler, Elmar ^b   Diederich, Daniel ^b   Walz, Lioba ^b   Rohleder, Hendrik ^b   Friese, Klaus ^a   Runnebaum, Ingo B ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 3; COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR; PROTEIN BCL 2; PROTEIN BCL XL;

ADENOCARCINOMA; ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CARCINOGENESIS; CELL CLONE; CELL STRAIN; CELL STRAIN A2780; CELL STRAIN CASKI; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; GENE OVEREXPRESSION; HELA CELL; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRECANCER; PRIORITY JOURNAL; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR MODEL; WESTERN BLOTTING;

ADENOCARCINOMA; ANIMALS; APOPTOSIS; BCL-X PROTEIN; BLOTTING, WESTERN; CASPASES; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; MICE; MICE, INBRED BALB C; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; PRECANCEROUS CONDITIONS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, VIRUS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UP-REGULATION;

EID: 20444435485     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-04-2370     Document Type: Article

References (27)

1. Bergelson JM, Cunningham JA, Droguett G, et al. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science 1997;275:1320-3.
2. Tomko RP, Xu R, Philipson L. HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc Natl Acad Sci U S A 1997;94:3352-6.
3. Bergelson JM, Krithivas A, Celi L, et al. The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses. J Virol 1998;72:415-9.
4. Pickles RJ, Fahrner JA, Petrella JM, Boucher RC, Bergelson JM. Retargeting the coxsackievirus and adenovirus receptor to the apical surface of polarized epithelial cells reveals the glycocalyx as a barrier to adenovirus-mediated gene transfer. J Virol 2000;74:6050-7.
5. Cohen CJ, Shieh JT, Pickles RJ, Okegawa T, Hsieh JT, Bergelson JM. The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction. Proc Natl Acad Sci U S A 2001; 98:15191-6.
6. Brüning A, Runnebaum IB. CAR is a cell-cell adhesion protein in human cancer cells and is expressionally modulated by dexamethasone, TNFα, and TGFβ. Gene Ther 2003;10:198-205.
7. Okegawa T, Li Y, Pong RC, Bergelson JM, Zhou J, Hsieh JT. The dual impact of coxsackie and adenovirus receptor expression on human prostate cancer gene therapy. Cancer Res 2000;60:5031-6.
8. Okegawa T, Pong RC, Li Y, Bergelson JM, Sagalowski AI, Hsieh JT. The mechanism of the growth-inhibitory effect of coxsackie and adenovirus receptor (CAR) on human bladder cancer: a functional analysis of car protein structure. Cancer Res 2001;61:6592-600.
9. Rauen KA, Sudilovsky D, Le JL, et al. Expression of the coxsackie adenovirus receptor in normal prostate and in primary and metastatic prostate carcinoma: potential relevance to gene therapy. Cancer Res 2002; 62:3812-8.
10. Quin M, Escuadro B, Dohadwala M, Sharma S, Batra RK. A novel role for the coxsackie adenovirus receptor in mediating tumor formation by lung cancer cells. Cancer Res 2004;64:6377-80.
11. Brüning A, Runnebaum IB. The coxsackie adenovirus receptor inhibits cancer cell migration. Exp Cell Res 2004;298:624-31.
12. Brüning A, Köhler T, Quist S, et al. Adenoviral transduction efficiency of ovarian cancer cells can be limited by loss of integrin p3 subunit expression and increased by reconstitution of integrin αvβ3. Hum Gene Ther 2001;12:391-9.
13. Kittrell FS, Oborn CJ, Medina D. Development of mammary preneoplasias in vivo from mouse mammary epithelial cell lines in vitro. Cancer Res 1992;52:1924-32.
14. Matter ML, Ruoslahti E. A signaling pathway from the α5β1 and α(v)β3 integrins that elevates bcl-2 transcription. J Biol Chem 2001;276:27757-63.
15. Heideman DA, Snijders PJ, Craanen ME, et al. Selective gene delivery toward gastric and esophageal adenocarcinoma cells via EpCAM-targeted adenoviral vectors. Cancer Gene Ther 2001;8:342-51.
16. Qin M, Chen S, Yu T, Escuado B, Sharma S, Batra RK. Coxsackievirus adenovirus receptor expression predicts the efficiency of adenoviral gene transfer into non-small cell lung cancer xenografts. Clin Cancer Res 2003;9:4992-9.
17. Stickeler E, Kittrell F, Medina D, Berget SM. Stage-specific changes in SR splicing factors and alternative splicing in mammary tumorigenesis. Oncogene 1999; 18:3574-82.
18. Cardiff RD, Aguilar-Cordova E. Proto-neoplasia revisited: the molecular biology of mouse mammary hyperplasia. Anticancer Res 1988;8:925-33.
19. Jerry DJ, Ozbun MA, Kittrell FS, Lane DP, Medina D, Butel JS. Mutations in p53 are frequent in the preneoplastic stage of mouse mammary tumor development. Cancer Res 1993;53:3374-81.
20. Medina D. Mammary tumor cell cycle, differentiation and metastases. In: Dickson RB, Lippman ME, editors. Norwell: Kluwer Academic Publishers; 1996. p. 37-69.
21. Giancotti FG, Ruoslahti E. Integrin signaling. Science 1999;285:1028-32.
22. Yap AS, Kovacs EM. Direct cadherin-activated cell signaling: a view from the plasma membrane. J Cell Biol 2003;160:11-6.
23. Ikeguchi M, Makino M, Kaibara N. Clinical significance of E-cadherin-catenin complex expression in metastatic foci of colorectal carcinoma. J Surg Oncol 2001;77:201-7.
24. Kanazawa N, Oda T, Gunji N, et al. E-cadherin expression in the primary tumors and metastatic lymph nodes of poorly differentiated types of rectal cancer. Surg Today 2002;32:123-8.
25. Chotia C, Jones EY. The molecular structure of cell adhesion molecules. Annu Rev Biochem 1997;66:823-62.
26. Christofori G, Semb H. The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem Sci 1999;24:73-6.
27. Zamai L, Ahmad M, Bennett IM, Azzoni L, Alnemri ES, Perussia B. Natural killer (NK) cell-mediated cytotoxicity: differential use of TRAIL and Fas ligand by immature and mature primary human NK cells. J Exp Med 1998;188:2375-80.