Safety and effectiveness of a new enzyme-targeting radiosensitization treatment (KORTUC II) for intratumoral injection for low-LET radioresistant tumors

International Journal of Oncology

Volumn 39, Issue 3, 2011, Pages 553-560

  Ogawa, Yasuhiro ^a   Kubota, Kei ^a   Ue, Hironobu ^a   Tadokoro, Michiko ^a   Matsui, Rina ^a   Yamanishi, Tomoaki ^a   Hamada, Norihiko ^a   Kariya, Shinji ^a   Nishioka, Akihito ^a   Nakajima, Hideki ^a   Tarutani, Masahito ^a   Sano, Shigetoshi ^a  

^a KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

Breast cancer; Hydrogen peroxide; Intratumoral injection; KORTUC; Radiosensitization; Radiosensitizer; Sodium hyaluronate; Ultrasound

Indexed keywords

HYALURONIC ACID; HYDROGEN PEROXIDE; RADIOSENSITIZING AGENT;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DRUG TOLERABILITY; FEMALE; HUMAN; INJECTION SITE PAIN; LINEAR ENERGY TRANSFER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RADIATION DERMATITIS; RADIOSENSITIVITY; RADIOSENSITIZATION; RECURRENT CANCER;

ADULT; AGED; AGED, 80 AND OVER; COMBINED MODALITY THERAPY; FEMALE; HUMANS; HYALURONIC ACID; HYDROGEN PEROXIDE; INJECTIONS, INTRALESIONAL; MALE; MELANOMA; MIDDLE AGED; RADIATION-SENSITIZING AGENTS; RADIOTHERAPY DOSAGE; RADIOTHERAPY, HIGH-ENERGY; TREATMENT OUTCOME;

EID: 79959959865     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.1069     Document Type: Article

References (24)

1. Jette DC, Wiebe LI and Chapman JD: Synthesis and in vivo studies of the radiosensitizer 4-[82Br]bromomisonidazole. Int J Nucl Med Biol 10: 205-210, 1983. (Pubitemid 14208486)
2. Coleman CN: Hypoxic cell radiosensitizers: Expectations and progress in drug development. Int J Radiat Oncol Biol Phys 11: 323-329, 1985.
3. Hall EJ. The oxygen effect and reoxygenation. In: Radiobiology for the Radiologist. 5th edition. JB. Lippincott Co., Philadelphia, PA, pp91-111, 2000.
4. Ogawa Y, Takahashi T, Kobayashi T, et al: Mechanism of apoptotic resistance of human osteosarcoma cell line, HS-Os-1, against irradiation. Int J Mol Med 12: 453-458, 2003.
5. Ogawa Y, Takahashi T, Kobayashi T, et al: Apoptotic-resistance of the human osteosarcoma cell line HS-Os-1 to irradiation is converted to apoptotic-susceptibility by hydrogen peroxide: a potent role of hydrogen peroxide as a new radiosensitizer. Int J Mol Med 12: 845-850, 2003.
6. Ogawa Y, Takahashi T, Kobayashi T, et al: Immunocytochemical characteristics of human osteosarcoma cell line HS-Os-1: Possible implication in apoptotic resistance against irradiation. Int J Mol Med 14: 397-403, 2004.
7. Kariya S, Sawada K, Kobayashi T, et al: Combination treatment of hydrogen peroxide and X-rays induces apoptosis in human prostate cancer PC-3 cells. Int J Radiat Oncol Biol Phys 75: 449-454, 2009.
8. Ogawa Y, Takahashi T, Kobayashi T, et al: Comparison of radiation-induced reactive oxygen species formation in adult articular chondrocytes and that in human peripheral T cells: Possible implication in radiosensitivity. Int J Mol Med 11: 455-459, 2003.
9. Ogawa Y, Ue H, Tsuzuki K, et al: New radiosensitization treatment (KORTUC I) using hydrogen peroxide solution-soaked gauze bolus for unresectable and superficially exposed neoplasms. Oncol Rep 19: 1389-1394, 2008.
10. Ogawa Y, Kubota K, Ue H, et al: Development and clinical application of a new radiosensitizer containing hydrogen peroxide and hyaluronic acid sodium for topical tumor injection - a new enzyme-targeting radiosensitization treatment, KORTUC II (Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas, Type II). Strahlenther. Onkol 183 (Sondernr. 2): 100-101, 2007.
11. Ogawa Y, Kubota K, Ue H, et al: Phase I study of a new radiosensitizer containing hydrogen peroxide and sodium hyaluronate for topical tumor injection: A new enzyme-targeting radiosensitization treatment, Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas, Type II (KORTUC II). Int J Oncol 34: 609-618, 2009.
12. Therasse P, Arbuck SG, Eisenhauer EA, et al: New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 92: 205-216, 2000. (Pubitemid 30099779)
13. Ogawa Y, Nishioka A, Hamada N, et al: Immunohistochemical study of c-fos-positive lymphocytes infiltrated into human squamous cell carcinomas of the head and neck during radiation therapy and its clinical significance. Clin Cancer Res 3: 2301-2307, 1997. (Pubitemid 28133149)
14. Ogawa Y, Nishioka A, Hamada N, et al: Expression of Fas (CD95/APO-1) antigen induced by radiation therapy for diffuse B-cell lymphoma: immunohistochemical study. Clin Cancer Res 3: 2211-2216, 1997. (Pubitemid 28133138)
15. Lawrence TS, Blackstock AW and McGinn C: The mechanism of action of radiosensitization of conventional chemotherapeutic agents. Semin Radiat Oncol 13: 13-21, 2003. (Pubitemid 36173256)
16. Bohm L, Roos WP and Serafin AM: Inhibition of DNA repair by pentoxifylline and related methylxanthine derivatives. Toxicol 193: 153-160, 2003. (Pubitemid 37340150)
17. Milas L: Cyclooxygenase-2 (COX-2) enzyme inhibitors as potential enhancers of tumor radioresponse. Semin Radiat Oncol 11: 290-299, 2001.
18. Choy H and Milas L: Enhancing radiotherapy with cyclooxygenase-2 enzyme inhibitors: a rational advance? J Natl Cancer Inst 95: 1440-1452, 2003. (Pubitemid 37279329)
19. Overgaad J: Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors. Oncol Res 6: 509-518, 1994.
20. Gerlach NL, Barkhuysen R, Kaanders JH, et al: The effect of hyperbaric oxygen therapy on quality of life in oral and oropharyngeal cancer patients treated with radiotherapy. Int J Oral Maxillofac Surg 37: 255-259, 2008. (Pubitemid 351335251)
21. Overgaad J: Hypoxic radiosensitization: adored and ignored. J Clin Oncol 25: 4066-4074, 2007.
22. Williamson RA: An experimental study of the use of hyperbaric oxygen to reduce the side effects of radiation treatment for malignant disease. Int J Oral Maxillofac Surg 36: 533-540, 2007.
23. Lichtenbaum R, De Souza AA and Jafar JJ: Intratumoral hydrogen peroxide injection during meningioma resection. Neurosurgery 59 (ONS Suppl. 4): S470-S473, 2006.
24. Prada PJ, Fernandez J, Martinez AA, et al: Transperineal injection of hyaluronic acid in anterior perirectal fat to decrease rectal toxicity from radiation delivered with intensity-modulated brachytherapy or EBRT for prostate cancer patients. Int J Radiat Oncol Biol Phys 69: 95-102, 2007. (Pubitemid 47247497)