Study on discriminating nephrotoxic components in zexie

Zhongguo Zhongyao Zazhi

Volumn 36, Issue 6, 2011, Pages 758-761

  Zhao, Xiaoping ^a,b   Lu, Lin ^b   Zhang, Yufeng ^c   Zhang, Boli ^a  

^a TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

Fluorescence label; Identification of toxic components in Chinese medicine; Nephrotoxicity; Zexie

Indexed keywords

16,23 OXIDO ALISOL B; ALISOL C; ALISOL O; FLUORESCEIN DIACETATE; HERBACEOUS AGENT; UNCLASSIFIED DRUG; ZEXIE;

ARTICLE; CELL ASSAY; CHEMICAL COMPOSITION; DRUG DETERMINATION; DRUG QUALITY; FLUORESCENCE ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NEPHROTOXICITY;

ALISMA; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; KIDNEY; LLC-PK1 CELLS; MASS SPECTROMETRY; SWINE;

EID: 79959956408     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: 10.4268/cjcmm20110624     Document Type: Article

References (10)

1. Yune M F, Tam S, Fung J. et al. Traditional Chinese medicine causing hepatotoxicity in patients with chronic hepatitis B infection: 1 -year prospective study [J]. Aliment Pharmacol Ther, 2006, 24(8):1179
2. Jin Y C, Zhao X P, Zhang Y F, et al. A three-stage-integrative approach for the identification of potential hepatotoxic compounds from botanical products [J]. Int J Toxicol, doi: 10.1177/10915818
3. Chen L L, Qi J, Chang Y X, et al. Identification and determination of the major constituents in traditional chinese medicinal formula Danggui-san by HPLC-DAD-MS/MS [J]. Pharm Biomed Anal, 2009, 50:127.
4. Yoshijro N, Yohko S, Masumi K, et al. Terpenoids of Alisma orientate Rhizome and the crude drug Alismatis rhizome [J]. Pytochemistry, 1994, 36(1):119.
5. Jiang Z Y, Zhang X M, Zhang F X, et al. A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis [J]. Planta Med, 2006, 72(10):951.
6. Steinmassl D, Pfaller W, Gstraunthaler G, et al. LLC-PK1 epithelia as a model for in vitro assessment of proximal tubular nephrotoxicity [J]. In Vitro Cell Dev Biol, 1995, 31:94.
7. L'Eplattenier H F, Zhao J M, Pfannkuch F, et al. Cell culture in nephrotoxicity testing [J]. Toxicol Lett, 1990, 53(1/2):227.
8. Jones K H, Senft J A. An improved method to determine cell viability by simultaneous staining with fluorescein diacetate-propidium iodide [J]. J Histochem Cytochem, 1985, 33(1):77.
9. Ross D D, Joneckis C C, Ordóez J V, et al. Estimation of cell survival by flow cytometric quantification of fluorescein diacetate/propidium iodide viable cell number [J]. Cancer Res, 1989, 49:3776.