The role of fibrinolytic genes and proteins in the development of allograft vascular disease

Journal of Heart and Lung Transplantation

Volumn 30, Issue 8, 2011, Pages 935-944

  Benza, Raymond L ^a   Passineau, Michael J ^a   Anderson, Peter G ^b   Barchue, Joseph P ^c   George, James F ^d  

^a ALLEGHENY GENERAL HOSPITAL   (United States)

^b University of Alabama at Birmingham   (United States)

^c University of Alabama at Birmingham   (United States)

^d Kentucky   (United States)

Author keywords

allograft coronary disease; cardiac transplant; fibrinolysis; intimal thickening; PAI 1

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; FIBRINOLYTIC FACTOR; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; UROKINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA GRAFT; ARTERY INTIMA PROLIFERATION; ARTICLE; CARDIAC GRAFT REJECTION; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; ISOGRAFT; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; UPREGULATION; WESTERN BLOTTING;

ANIMALS; AORTA, ABDOMINAL; CELL PROLIFERATION; CORONARY ARTERY DISEASE; DISEASE MODELS, ANIMAL; FIBRINOLYSIS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; RNA, MESSENGER; TISSUE PLASMINOGEN ACTIVATOR; TRANSPLANTATION, HOMOLOGOUS; TUNICA INTIMA; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 79959944017     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2011.04.002     Document Type: Article

References (55)

1. C.A. Labarrere, and M.C. Deng Microvascular prothrombogenicity and transplant coronary artery disease Transpl Immunol 2 2002 243 249
2. T.M. Sartori, P.G. Maurizio, and P. Sara Relation between long-term steroid treatment after heart transplantation, hypofibrinolysis and myocardial microthrombi generation J Heart Lung Transplant 18 1999 693 700 (Pubitemid 29362005)
3. R.L. Benza, P.G. Anderson, and K. Lyle Donor PAI-1 expression inhibits the intimal response of early allograft vascular disease J Heart Lung Transplant 22 2003 515 518 (Pubitemid 36549049)
4. R.L. Benza, M.A. Cavender, and J. Barchue Alterations in the fibrinolytic cascade post-transplant: evidence of a bimodal expression pattern J Heart Lung Transplant 26 2007 494 497 (Pubitemid 46602015)
5. M.K. Warshofsky, H.S. Wasserman, and W. Wang Plasma levels of tissue plasminogen activator and plasminogen activator inhibitor-1 are correlated with the presence of transplant coronary artery disease in cardiac transplant recipients Am J Cardiol 80 1997 145 149 (Pubitemid 27329211)
6. B.J. Hunt, Segal, and M. Yacoub Hemostatic changes in heart transplant recipients and their relationship to accelerated coronary sclerosis Transplantation 55 1993 309 315 (Pubitemid 23065461)
7. C.A. Labarrere, D.R. Nelson, and W.P. Faulk Myocardial fibrin deposits in the first month after transplantation predict subsequent coronary artery disease and graft failure in cardiac allograft recipients Am J Med 105 1998 207 213 (Pubitemid 28443209)
8. R.L. Benza, H.E. Grenett, and R.C. Bourge Gene polymorphisms for PAI-1/t-PA and development of allograft coronary artery disease Circulation 98 1998 2248 2254
9. C.A. Labarrere, D. Pitts, D.R. Nelson, and W.P. Faulk Vascular tissue plasminogen activator and the development of coronary artery disease in heart-transplant recipients N Engl J Med 333 1995 1111 1116
10. C.A. Labarrere, D. Pitts, H. Halbrook, and W.P. Faulk Tissue plasminogen activator, plasminogen activator inhibitor-1, and fibrin as indexes of clinical course in cardiac allograft recipients: an immunocytochemical study Circulation 89 1994 1599 1608 (Pubitemid 24114237)
11. J.B. Dugid Thrombosis as a factor in the pathogenesis of coronary atherosclerosis J Pathol Bacteriol 58 1946 207 212
12. M.A. Reidy, C. Irvin, and V. Lindner Migration of arterial wall cells Expression of plasminogen activators and inhibitors in injured rat arteries Circ Res 78 1996 405 414 (Pubitemid 26068958)
13. P. Carmeliet, and D. Collen Molecular genetics of the fibrinolytic and coagulation systems in haemostasis, thrombogenesis, restenosis and atherosclerosis Curr Opin Lipidol 8 1997 118 125 (Pubitemid 27235072)
14. A. Hamsten, M. Blomback, B. Wiman, J. Svenson, U. de Faire, and L. Mettinger Haemostatic function in myocardial infarction Brit Heart J 55 1986 58 66 (Pubitemid 16131409)
15. V.A. Ploplis, and F.J. Castellino Nonfibrinolytic functions of plasminogen Methods 21 2000 103 110 (Pubitemid 32896756)
16. M. Gyongyosi, D. Glogar, and F. Weidinger Association between plasmin activation system and intravascular ultrasound signs of plaque instability in patients with unstable angina and non-st-segment elevation myocardial infarction Am Heart J 147 2004 158 164 (Pubitemid 38037413)
17. E. Dejana, L.R. Languino, and N. Polentarutti Interaction between fibrinogen and cultured endothelial cells: Induction of migration and specific binding J Clin Invest 75 1985 11 18 (Pubitemid 15163960)
18. M. Naito, T. Hayashi, M. Kuzuya, C. Funaki, K. Asai, and F. Kuzuya Fibrinogen is chemotactic for vascular smooth muscle cells FEBS Lett 247 1989 358 360 (Pubitemid 19129280)
19. S. Mustjoki, H. Tapiovaara, V. Siren, and A. Vaheri Interferons and retinoids enhance and dexamethasone suppresses urokinase-mediated plasminogen activation in promyelocytic leukemia cells Leukemia 12 1998 164 174 (Pubitemid 28108068)
20. M. Xiaoli, H. Wenying, and S. Mingpeng Effects and mechanism of tissue-type plasminogen activator and plasminogen activator inhibitor on vascular smooth muscle cell proliferation Int J Cardiol 66 suppl 1 1998 S57 S64
21. A. Hamsten, B. Wiman, V. de Faire, and M. Blomback Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction N Engl J Med 313 1985 1557 1563 (Pubitemid 16177394)
22. J.M. Herbert, and P. Carmeliet Involvement of u-PA in the anti-apoptotic activity of TGFbeta for vascular smooth muscle cells FEBS Lett 413 1997 401 404 (Pubitemid 27371472)
23. J.E. Portielje, W.H. Kruit, and A.J. Eerenberg Interleukin 12 induces activation of fibrinolysis and coagulation in humans Br J Haematol 112 2001 499 505 (Pubitemid 32183501)
24. R.L. Benza, and J.F. George Aortic graft transplantation in mice J Heart Lung Transplant 21 2002 1319 1321 (Pubitemid 35477748)
25. A. Raisanen-Sokolowski, T. Glysing-Jenson, P.L. Mottram, and M.E. Russell Sustained anti-CD4/CD8 treatment blocks inflammatory activation and intimal thickening in mouse allografts Arterioscler Thromb Vasc Biol 17 1997 2115 2122 (Pubitemid 28060604)
26. A.M. Keogh, H.A. Valantine, and S.A. Hunt Impact of proximal or midvessel discrete coronary artery stenoses on survival after heart transplantation J Heart Lung Transplant 11 1992 892 901
27. D.E. Johnson, S.Z. Gao, J.S. Schroeder, W.M. DeCampli, and M.E. Billingham The spectrum of coronary artery pathologic findings in human cardiac allografts J Heart Transplant 8 1989 349 359 (Pubitemid 19247624)
28. C.P. Bieber, E.B. Stinson, N.E. Shumway, R. Payne, and J. Kosek Cardiac transplantation in man VII. Cardiac allograft pathology Circulation 41 1970 753 772
29. M.E. Billingham Cardiac transplant atherosclerosis Transplant Proc 19 4 suppl 5 1987 19 24
30. H.O. Ventura, S.R. Ramee, and A. Jain Coronary artery imaging with intravascular ultrasound in patients following cardiac transplantation Transplantation 53 1992 216 219
31. H. Tsutsui, K.M. Ziada, and P. Schoenhagen Lumen loss in transplant coronary artery disease is a biphasic process involving early intimal thickening and late constrictive remodeling: Results from a 5-year serial intravascular ultrasound study Circulation 104 2001 653 657 (Pubitemid 32738518)
32. M.R. Mehra, H.O. Ventura, D.D. Stapleton, F.W. Smart, T.C. Collins, and S.R. Ramee Presence of severe intimal thickening by intravascular ultrasonography predicts cardiac events in cardiac allograft vasculopathy J Heart Lung Transplant 14 1995 632 639
33. P.R. Rickenbacher, F.J. Pinto, and N.P. Lewis Prognostic importance of intimal thickness as measured by intracoronary ultrasound after cardiac transplantation Circ 92 1995 3445 3452
34. C.J. Uys, and A.G. Rose Pathologic findings in long-term cardiac transplants Arch Pathol Lab Med 108 1984 112 116 (Pubitemid 14181707)
35. M.E. Billingham Pathology of graft vascular disease after heart and heart-lung transplantation and its relationship to obliterative bronchiolitis Transplant Proc 27 1995 2013 2016
36. H. Sawa, C. Lundgren, B.E. Sobel, and S. Fujii Increased intramural expression of plasminogen activator inhibitor type 1 after balloon injury: a potential progenitor of restenosis J Am Coll Cardiol 24 1994 1742 1748 (Pubitemid 24369201)
37. P. Carmeliet, L. Moons, V. Ploplis, E. Plow, and D. Collen Impaired arterial neointima formation in mice with disruption of the plasminogen gene J Clin Invest 99 1997 200 208 (Pubitemid 27053462)
38. J. Koglin, T. Glysing-Jenson, J.S. Mudgett, and M.E. Russell Exacerbated transplant arteriosclerosis in inducible nitric oxide-deficient mice Circ 97 1998 2059 2065 (Pubitemid 28243669)
39. P. Carmeliet, L. Schoonjans, and L. Kieckens Physiological consequences of loss of plasminogen activator gene function in mice Nature 368 1994 419 424 (Pubitemid 24115347)
40. G.W. Prager, J.M. Breuss, S. Steurer, J. Mihaly, and B.R. Binder Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells Blood 103 2004 955 962 (Pubitemid 38129556)
41. L.M. Kilpatrick, R.L. Harris, and K.A. Owen Initiation of plasminogen activation on the surface of monocytes expressing the type II transmembrane serine protease matriptase Blood 108 2006 2616 2623
42. P. Moran, W. Li, B. Fan, R. Vij, C. Eigenbrot, and D. Kirchhofer Pro-urokinase-type plasminogen activator is a substrate for hepsin J Biol Chem 281 2006 30439 30446 (Pubitemid 44596152)
43. B.R. Binder, J. Mihaly, and G.W. Prager uPAR-uPA-PAI-1 interactions and signaling: a vascular biologist's view Thromb Haemost 97 2007 336 342 (Pubitemid 46437793)
44. G. Bu, I. Warshawsky, and A.L. Schwartz Cellular receptors for the plasminogen activators Blood 83 1994 3427 3436 (Pubitemid 24175528)
45. B.J. Hunt, Segal, and M. Yacoub Hemostatic changes in heart transplant recipients and their relationship to accelerated coronary sclerosis Transplantation 55 1993 309 315 (Pubitemid 23065461)
46. C.R. Meckel, T.J. Anderson, and G.H. Mudge Hemostatic/fibrinolytic predictors of allograft coronary artery disease after cardiac transplantation Vasc Med 2 1997 306 312 (Pubitemid 28212098)
47. W.P. Faulk, C.A. Laberrere, D. Pitts, and H. Halbrook Anticoagulant and fibrinolytic pathways in normal and transplanted human hearts J Heart Lung Transplant 11 1992 211
48. C.A. Labarrere, D.R. Nelson, C.J. Cox, D. Pitts, P. Kirlin, and H. Halbrook Cardiac-specific troponin I levels and risk of coronary artery disease and graft failure following heart transplantation JAMA 284 2000 457 464 (Pubitemid 30484479)
49. C.A. Labarrere, and W.P. Faulk Microvascular perturbations in human allografts: analogies in preeclamptic placentae Am J Reprod Immunol 27 1992 109 116
50. W.P. Faulk, and C.A. Laberrere Vascular immunopathology and atheroma development in human allografted organs Arch Pathol Lab Med 116 1992 1337 1344
51. K.A. Hajjar, D. Gavish, J.L. Breslow, and R.L. Nachman Lipoprotein (a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis Nature 339 1989 303 305 (Pubitemid 19130696)
52. K. Sakata, F. Miura, and H. Sugino Impaired fibrinolysis early after percutaneous transluminal coronary angioplasty is associated with restenosis Am Heart J 131 1996 1 6 (Pubitemid 26021357)
53. C.J. Schwartz, A.J. Valente, J.L. Kelley, E.A. Sprague, and E.H. Edwards Thrombosis and the development of atherosclerosis: Rokitansky revisited Semin Thromb Hemost 14 1988 189 195
54. E.B. Smith, and W.D. Thompson Fibrin as a factor in atherogenesis Thromb Res 73 1994 1 19 (Pubitemid 24062500)
55. L. Moons, C. Shi, and V. Ploplis Reduced transplant arteriosclerosis in plasminogen-deficient mice J Clin Invest 102 1998 1788 1797 (Pubitemid 28533825)