Down-regulated expression of IKZF1 mRNA in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

Rheumatology International

Volumn 31, Issue 6, 2011, Pages 819-822

  Hu, Wenlong ^a,b   Sun, Liangdan ^a,b   Gao, Jinping ^a,b   Li, Yun ^a,b   Wang, Peiguang ^a,b   Cheng, Yilin ^b   Pan, Tingmeng ^a,b   Han, Jianwen ^a,b   Liu, Yangsheng ^a,b   Lu, Wensheng ^a,b   Zuo, Xianbo ^b   Sheng, Yujun ^a,b   Yao, Sha ^a,b   He, Caifeng ^a,b   Yu, Zeying ^a,b   Yin, Xianyong ^b   Cui, Yong ^a,b   Yang, Sen ^a,b   Zhang, Xuejun ^a,b  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

IKZF1; Peripheral blood mononuclear cells; Real time reverse transcription polymerase chain reaction; Systemic lupus erythematosus

Indexed keywords

MESSENGER RNA;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DOWN REGULATION; FEMALE; GENE; HUMAN; HUMAN CELL; IKZF1 GENE; MAJOR CLINICAL STUDY; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION; HEALTH STATUS; HUMANS; IKAROS TRANSCRIPTION FACTOR; LEUKOCYTES, MONONUCLEAR; LUPUS ERYTHEMATOSUS, SYSTEMIC; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX;

EID: 79959942047     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-010-1576-1     Document Type: Article

References (21)

1. D Deapen A Escalante L Weinrib, et al. 1992 A revised estimate of twin concordance in systemic lupus erythematosus Arthritis Rheum 35 311 318 10.1002/art.1780350310 1536669 10.1002/art.1780350310 1:STN:280: DyaK387mt1SktQ%3D%3D
2. TJ Vyse BL Kotzin 1998 Genetic susceptibility to systemic lupus erythematosus Annu Rev Immunol 16 261 292 10.1146/annurev.immunol.16.1.261 9597131 10.1146/annurev.immunol.16.1.261 1:CAS:528:DyaK1cXislygtb0%3D (Pubitemid 28183366)
3. W Yang P Ng M Zhao, et al. 2009 Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese Genes Immun 10 219 226 10.1038/gene.2009.1 19225526 10.1038/gene.2009.1 1:CAS:528:DC%2BD1MXkvVSrurc%3D
4. JW Han HF Zheng Y Cui, et al. 2009 Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus Nat Genet 41 1234 1237 10.1038/ng.472 19838193 10.1038/ng.472 1:CAS:528:DC%2BD1MXht1Ogsr3E
5. K Georgopoulos M Bigby JH Wang A Molnar P Wu S Winandy A Sharpe 1994 The Ikaros gene is required for the development of all lymphoid lineages Cell 79 143 156 0092-8674(94)90407-3 7923373 10.1016/0092-8674(94)90407-3 1:CAS:528:DyaK2cXmslemtLc%3D (Pubitemid 24309520)
6. H Wojcik E Griffiths S Staggs J Hagman S Winandy 2007 Expression of a non-DNA-binding Ikaros isoform exclusively in B cells leads to autoimmunity but not leukemogenesis Eur J Immunol 37 1022 1032 10.1002/eji.200637026 17357110 10.1002/eji.200637026 1:CAS:528:DC%2BD2sXkvVSgsLg%3D (Pubitemid 46925339)
7. EM Tan AS Cohen JF Fries, et al. 1982 The 1982 revised criteria for the classification of systemic lupus erythematosus Arthritis Rheum 25 1271 1277 10.1002/art.1780251101 7138600 10.1002/art.1780251101 1:STN:280: DyaL3s%2FkvVCmtA%3D%3D (Pubitemid 13221242)
8. MC Hochberg 1997 Updating the American college of rheumatology revised criteria for the classification of systemic lupus erythematosus Arthritis Rheum 40 1725 10.1002/1529-0131(199709)40:9<1725::AID-ART29>3.0.CO;2-Y 9324032 10.1002/art.1780400928 1:STN:280:DyaK2svmsVaisw%3D%3D
9. C Bombardier DD Gladman MB Urowitz D Caron CH Chang 1992 Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE Arthritis Rheum 35 630 640 10.1002/art.1780350606 1599520 10.1002/art.1780350606 1:STN:280:DyaK383oslWrtg%3D%3D
10. CC Mok CS Lau 2003 Pathogenesis of systemic lupus erythematosus J Clin Pathol 56 481 490 10.1136/jcp.56.7.481 12835292 10.1136/jcp.56.7.481 1:STN:280:DC%2BD3szgslCjuw%3D%3D (Pubitemid 36819418)
11. P Kirstetter M Thomas A Dierich P Kastner S Chan 2002 Ikaros is critical for B cell differentiation and function Eur J Immunol 32 720 730 10.1002/1521-4141(200203)32:3<720::AID-IMMU720>3.0.CO;2-P 11870616 10.1002/1521-4141(200203)32:3<720::AID-IMMU720>3.0.CO;2-P 1:CAS:528:DC%2BD38Xitl2ns78%3D (Pubitemid 34257550)
12. JH Wang A Nichogiannopoulou L Wu L Sun AH Sharpe M Bigby K Georgopoulos 1996 Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation Immunity 5 537 549 S1074-7613(00)80269-1 8986714 10.1016/S1074-7613(00)80269-1 1:CAS:528:DyaK2sXitFCquw%3D%3D (Pubitemid 27062064)
13. S Winandy L Wu JH Wang K Georgopoulos 1999 Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros J Exp Med 190 1039 1048 10.1084/jem.190.8.1039 10523602 10.1084/jem.190.8.1039 1:CAS:528:DyaK1MXmslKisro%3D (Pubitemid 29496497)
14. WH Yap E Yeoh A Tay S Brenner B Venkatesh 2005 STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells FEBS Lett 579 4470 4478 10.1016/j.febslet.2005.07.018 16081070 10.1016/j.febslet.2005.07.018 1:CAS:528:DC%2BD2MXnslynsbo%3D (Pubitemid 41116384)
15. S Kobayashi K Ikari H Kaneko, et al. 2008 Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population Arthritis Rheum 58 1940 1946 10.1002/art.23494 18576330 10.1002/art.23494 (Pubitemid 351988085)
16. RJ Palomino-Morales A Rojas-Villarraga CI Gonzalez G Ramirez JM Anaya J Martin 2008 STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians Genes Immun 9 379 382 10.1038/gene.2008.30 18432273 10.1038/gene.2008.30 1:CAS:528:DC%2BD1cXms1equrg%3D (Pubitemid 351791494)
17. JB Harley ME Alarcon-Riquelme LA Criswell, et al. 2008 Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci Nat Genet 40 204 210 10.1038/ng.81 18204446 10.1038/ng.81 1:CAS:528:DC%2BD1cXhtl2qt7o%3D (Pubitemid 351171405)
18. S Sigurdsson G Nordmark S Garnier, et al. 2008 A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5 Hum Mol Genet 17 2868 2876 10.1093/hmg/ddn184 18579578 10.1093/hmg/ddn184 1:CAS:528:DC%2BD1cXhtVGgt7fN
19. A Ghadiri M Duhamel A Fleischer A Reimann F Dessauge A Rebollo 2007 Critical function of Ikaros in controlling Aiolos gene expression FEBS Lett 581 1605 1616 10.1016/j.febslet.2007.03.025 17383641 10.1016/j.febslet.2007.03.025 1:CAS:528:DC%2BD2sXjvFGrtrY%3D (Pubitemid 46528925)
20. JH Wang N Avitahl A Cariappa, et al. 1998 Aiolos regulates B cell activation and maturation to effector state Immunity 9 543 553 S1074-7613(00)80637-8 9806640 10.1016/S1074-7613(00)80637-8 1:CAS:528: DyaK1cXnsVylt7g%3D (Pubitemid 28499205)
21. J Sun G Matthias MJ Mihatsch K Georgopoulos P Matthias 2003 Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice J Immunol 170 1699 1706 12574333 1:CAS:528:DC%2BD3sXht12it70%3D (Pubitemid 36197384)