Design, synthesis and biological evaluation of 2′-deoxy-2′, 2′-difluoro-5-halouridine phosphoramidate ProTides

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 14, 2011, Pages 4338-4345

  Quintiliani, Maurizio ^a   Persoons, Leentje ^b   Solaroli, Nicola ^c   Karlsson, Anna ^c   Andrei, Graciela ^b   Snoeck, Robert ^b   Balzarini, Jan ^b   McGuigan, Christopher ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Antiviral; Feline herpes; Herpes virus; Nucleoside; Nucleotide; Phosphoramidate; Pro drug; ProTide

Indexed keywords

(3,5 DI O BENZOYL 2 DEOXY 2,2 DIFLUORO BETA DEXTRO ERYTHRO PENTOFURANOS 1 YL) 5 BROMOURACIL; (3,5 DI O BENZOYL 2 DEOXY 2,2 DIFLUORO BETA DEXTRO ERYTHRO PENTOFURANOS 1 YL) 5 IODOURACIL; 1 (2 DEOXY 2,2 DIFLUORO BETA DEXTRO ERYTHRO PENTOFURANOS 1 YL) 5 BROMOURACIL; 1 (2 DEOXY 2,2 DIFLUORO BETA DEXTRO ERYTHRO PENTOFURANOS 1 YL) 5 CHLOROURACIL; 1 (2 DEOXY 2,2 DIFLUORO BETA DEXTRO ERYTHRO PENTOFURANOS 1 YL) 5 IODOURACIL; 1 (2 DEOXY 2,2 DIFLUORO BETA DEXTRO ERYTHRO PENTOFURANOS 1 YL)THYMINE; 1 (3,5 DI O BENZOYL 2 DEOXY 2,2 DIFLUORO BETA DEXTRO ERYTHRO PENTOFURANOS 1 YL) 5 CHLOROURACIL; 1 (3,5 DI O BENZOYL 2 DEOXY 2,2 DIFLUORO BETA DEXTRO ERYTHRO PENTOFURANOS 1 YL)THYMINE; 2 DEOXY DEXTRO ERYTHRO 2,2 DIFLUORO RIBOFURANOSE 3,5 DIBENZOATE; 2 DEOXY DEXTRO ERYTHRO 2,2 DIFLUORO RIBOFURANOSE 3,5 DIBENZOATE 1 METHANESULFONATE; 2' DEOXY 2' FLUORO DEXTRO 5 IODOURIDINE 5' O NAPHTHYL(BENZOXY ALANINYL)PHOSPHATE; 2' DEOXY 2' FLUORO DEXTRO 5 IODOURIDINE 5' O NAPHTHYL(METHOXY ALANINYL)PHOSPHATE; 2' DEOXY 2',2' DIFLUORO 5 HALOURIDINE; 2' DEOXY 2',2' DIFLUORO DEXTRO 5 BROMOURIDINE 5' O PHENYL(BENZOXY ALANINYL)PHOSPHATE; 2' DEOXY 2',2' DIFLUORO DEXTRO 5 CHLOROURIDINE 5' O PHENYL(BENZOXY ALANINYL)PHOSPHATE; 2' DEOXY 2',2' DIFLUORO DEXTRO 5 IODOURIDINE 5' O PHENYL(BENZOXY ALANINYL)PHOSPHATE; 2' DEOXY 2',2' DIFLUORO DEXTRO 5 IODOURIDINE 5' O PHENYL(METHOXY ALANINYL)PHOSPHATE; 5 (2 BROMOVINYL) 2' DEOXYURIDINE; ACICLOVIR; ANTIVIRUS AGENT; CIDOFOVIR; GANCICLOVIR; NAPHTHYL(BENZOXY LEVO ALANINYL)PHOSPHOROCHLORIDATE; NAPHTHYL(METHOXY LEVO ALANINYL)PHOSPHOROCHLORIDATE; PHENYL(BENZOXY LEVO ALANINYL)PHOSPHOROCHLORIDATE; PHENYL(METHOXY LEVO ALANINYL)PHOSPHOROCHLORIDATE; PHOSPHORAMIDIC ACID DERIVATIVE; UNCLASSIFIED DRUG; URIDINE DERIVATIVE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IC 50; NONHUMAN; VIRUS REPLICATION;

AMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FLOXURIDINE; HEPACIVIRUS; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; PHOSPHORIC ACIDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

FELIDAE; HERPES; HERPESVIRIDAE;

EID: 79959932011     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.05.037     Document Type: Article

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