Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells

Archives of Pharmacal Research

Volumn 34, Issue 3, 2011, Pages 469-475

  Shoji, Kaori ^a,b   Tsubaki, Masanobu ^a   Yamazoe, Yuzuru ^c   Satou, Takao ^d   Itoh, Tatsuki ^d   Kidera, Yasuhiro ^c   Tanimori, Yoshihiro ^c   Yanae, Masashi ^d   Matsuda, Hideaki ^a   Taga, Atsushi ^a   Nakamura, Haruyuki ^b   Nishida, Shozo ^a  

^a KINKI UNIVERSITY   (Japan)

^b Higashiosaka City General Hospital   (Japan)

^c KINDAI UNIVERSITY HOSPITAL   (Japan)

^d KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Acute myeloid leukemia; Apoptosis; Bcl xL; HL 60; Mangiferin; NF B

Indexed keywords

BIM PROTEIN; CASPASE 3; DNA; MANGIFERIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; TRANSCRIPTION FACTOR RELA; X LINKED INHIBITOR OF APOPTOSIS;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL NUCLEUS; CELL VIABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-X PROTEIN; BLOTTING, WESTERN; CASPASE 3; CELL NUCLEUS; CELL SURVIVAL; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HL-60 CELLS; HUMANS; NF-KAPPA B; PROTEIN TRANSPORT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN; XANTHONES;

EID: 79959926053     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-011-0316-8     Document Type: Article

References (20)

1. Aribi, A., Ravandi, F., and Giles, F., Novel agents in acute myeloid leukemia. Cancer J., 12, 77-91 (2006).
2. Bueso-Ramos, C. E., Rocha, F. C., Shishodia, S., Medeiros, L. J., Kantarjian, H. M., Vadhan-Raj, S., Estrov, Z., Smith, T. L., Nguyen, M. H., and Aggarwal, B. B., Expression of constitutively active nuclear-kappa B RelA transcription factor in blasts of acute myeloid leukemia. Hum. Pathol., 35, 246-253 (2004). (Pubitemid 38240909)
3. Frelin, C., Imbert, V., Griessinger, E., Peyron, A. C., Rochet, N., Philip, P., Dageville, C., Sirvent, A., Hummelsberger, M., Bérard, E., Dreano, M., Sirvent, N., and Peyron, J. F., Targeting NF-kappaB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells. Blood, 105, 804-811 (2005). (Pubitemid 40070768)
4. Ghosh, S., May, M. J., and Kopp, E. B., NF-κ and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol., 16, 225-260 (1998). (Pubitemid 28183365)
5. Glimore, T. D., Introduction: the Rel/NF-κ signal transduction pathway. Semin. Cancer Biol., 8, 61-62 (1997).
6. Glimore, T. D., Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel. Oncogene, 18, 6925-6937 (1999).
7. Green, D. R. and Evan, G. I., A matter of life and death. Cancer Cell, 1, 19-30 (2002). (Pubitemid 41039172)
8. Grimwade, D., Walker, H., Harrison, G., Oliver, F., Chatter, S., Harrison, C. J., Wheatley, K., Burnett, A. K., and Goldstone, A. H., Medical Research Council Adult Leukemia Working Party, The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial. Blood, 98, 1312-1320 (2001).
9. Guzman, M. L., Neering, S. J., Upchurch, D., Grimes, B., Howard, D. S., Rizzieri, D. A., Luger, S. M., and Jordan, C. T., Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukaemia cells. Blood, 98, 2301-2307 (2001).
10. Harris, M. H. and Thompson, C. B., The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability. Cell Death Differ., 7, 1182-1191 (2000). (Pubitemid 32042225)
11. Jeong, S. Y. and Seol, D. W., The role of mitochondria in apoptosis. BMB Rep., 41, 11-22 (2008).
12. Jin, X., Lin, Q., Zhang, D., Zhang, M., Wang, Z., Guo, Z., Peng, M., Deng, C., and Guo, C., Chemosensitization in non-small cell lung cancer cells by IKK inhibitor occurs via NF-κ and mitochondrial cytochrome c cascade. J. Cell. Mol. Med., 13, 4596-4607 (2009).
13. Karin, M. and Lin, A., NF-κ at the crossroads of life and death. Nat. Immunol., 3, 221-227 (2002).
14. Kelekar, A. and Thompson, C. B., Bcl-2-family protein: the role of the BH3 domain in apoptosis. Trends Cell Biol., 8, 324-330 (1998). (Pubitemid 28362590)
15. Kimby, H., Nygren, P., and Glimelius, B., A systematic overview of chemotherapy effects in acute myeloid leukemia. Acta Oncol., 40, 231-252 (2001). (Pubitemid 32590834)
16. Matsuda, H., Tokunaga, M., Iwahashi, H., Naruto, S., Yagi, H., Masuko, T., and Kubo, M., Studies on Plauan Medical Herbs. II. Activation of mouse macrophages RAW264.7 by ongael, leaves of Phaleria cumingii (MEISN.) F. VILL. and its acylglucosylsterols. Biol. Pharm. Bull., 28, 929-933 (2005a). (Pubitemid 40740672)
17. Matsuda, H., Tokunaga, M., Iwahashi, H., Naruto, S., Yagi, H., Masuko, T., and Kubo, M., Studies on Plauan Medical Herbs. III. Antitumor and immunostimulatory activities of Ongel, leaves of Phaleria cumingii (MEISN.) F. VILL. J. Trad. Med., 22, 314-320 (2005b).
18. Ravi, R. and Bedi, A., NF-κ in cancer?a friend turned foe. Drug Resist. Updat., 7, 53-67 (2004).
19. Sethi, G., Ahn, K. S., and Aggarwal, B. B., Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis. Mol. Cancer Res., 6, 1059-1070 (2008).
20. Zamzami, N., Marchetti, P., Castedo, M., Zanin, C., Vayssiere, J. L., Petit, P. X., and Kroemer, G., Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J. Exp. Med., 181, 1661-1672 (1995).