Osteogenic effects of flavonoid aglycones from an osteoprotective fraction of Drynaria fortunei - An in vitro efficacy study

Phytomedicine

Volumn 18, Issue 10, 2011, Pages 868-872

  Wang, Xinluan ^a,d   Zhen, Lizhen ^a   Zhang, Ge ^a   Wong, Man Sau ^c   Qin, Ling ^a,d   Yao, Xinsheng ^b  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b JINAN UNIVERSITY   (China)

^c HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^d INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

Differentiation; Drynaria fortunei; Flavonoid aglycones; Mineralization; Osteoblastic UMR 106 cells

Indexed keywords

AGLYCONE; ALKALINE PHOSPHATASE; CALCIUM; CHINESE DRUG; DRYNARIA FORTUNEI EXTRACT; ESTROGEN RECEPTOR; FLAVONOID; HORMONE RECEPTOR BLOCKING AGENT; KURARINONE; NARINGENIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE MINERALIZATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CHINESE HERB; CONTROLLED STUDY; DRUG EFFICACY; DRYNARIA FORTUNEI; HUMAN; IN VITRO STUDY; NONHUMAN; OSTEOBLAST; OSTEOPOROSIS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ALKALINE PHOSPHATASE; ANIMALS; CALCIFICATION, PHYSIOLOGIC; CALCIUM; CELL LINE; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; DURAPATITE; FLAVANONES; FLAVONOIDS; OSTEOBLASTS; POLYPODIACEAE; RATS; RHIZOME;

DRYNARIA FORTUNEI; MUS;

EID: 79959921754     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2011.01.022     Document Type: Article

References (37)

1. Y. Chan, C.H. Lai, H.W. Yang, Y.Y. Lin, and C.H. Chan The evaluation of Chinese herbal medicine effectiveness on periodontal pathogens Am. J. Chin. Med. 31 2003 751 761 (Pubitemid 41758798)
2. L.L. Chen, Q. Tang, and J. Yan Therapeutic effect of aqueous-extract from a traditional Chinese medical herb Drynaria fortunei on rat experimental model of alveolar bone resorption Zhongguo Zhong Yao Za Zhi 29 2004 549 553
3. H.A. Declercq, R.M. Verbeeck, L.I. De Ridder, E.H. Schacht, and M.J. Cornelissen Calcification as an indicator of osteoinductive capacity of biomaterials in osteoblastic cell cultures Biomaterials 26 2005 4964 4974 (Pubitemid 40357686)
4. P. Ding, Q. Tang, and L. Chen Effects of naringin on proliferation, differentiation and matrix mineralization of MC3T3-E1 cells Zhongguo Zhong Yao Za Zhi 34 2009 1712 1716
5. G.C. Dong, H.M. Chen, and C.H. Yao A novel bone substitute composite composed of tricalcium phosphate, gelatin and drynaria fortunei herbal extract J. Biomed. Mater. Res. A 84 2008 167 177
6. M. Gu, and J.N. Guo Treatment of Gusuibu on primary osteoporosis Chin. J. Rehabil. 19 2004 297
7. L.V. Hale, Y.F. Ma, and R.F. Santerre Semi-quantitative fluorescence analysis of calcein binding as a measurement of in vitro mineralization Calcif. Tissue Int. 67 2000 80 84 (Pubitemid 30460954)
8. V.D. La, S. Tanabe, and D. Grenier Naringenin inhibits human osteoclastogenesis and osteoclastic bone resorption J. Periodontal Res. 44 2009 193 198
9. F. Li, F. Meng, Z. Xiong, Y. Li, R. Liu, and H. Liu Stimulative activity of Drynaria fortunei (Kunze) J. Sm. extracts and two of its flavonoids on the proliferation of osteoblastic like cells Pharmazie 61 2006 962 965 (Pubitemid 44807272)
10. H.C. Liu, R.M. Chen, W.C. Jian, and Y.L. Lin Cytotoxic and antioxidant effects of the water extract of the traditional Chinese herb gusuibu (Drynaria fortunei) on rat osteoblasts J. Formos. Med. Assoc. 100 2001 383 388
11. W. Lu, X.G. Chu, and T.P. Peng Clinical study of Bu-Shen-Jian-Gu soup on primary osteoporosis Jiangxi J. Tradit. Chin. Med. 35 2004 27
12. L. Malaval, A.K. Gupta, F. Liu, P.D. Delmas, and J.E. Aubin LIF, but not IL-6, regulates osteoprogenitor differentiation in rat calvaria cell cultures: modulation by dexamethasone J. Bone Miner. Res. 13 1998 175 184 (Pubitemid 28082373)
13. K. Mandadi, M. Ramirez, G.K. Jayaprakasha, B. Faraji, M. Lihono, F. Deyhim, and B.S. Patil Citrus bioactive compounds improve bone quality and plasma antioxidant activity in orchidectomized rats Phytomedicine 16 2009 513 520
14. S. Milligan, J. Kalita, V. Pocock, A. Heyerick, L. De Cooman, H. Rong, and D. De Keukeleire Oestrogenic activity of the hop phyto-oestrogen, 8-prenylnaringenin Reproduction 123 2002 235 242 (Pubitemid 34144673)
15. K. Murota, S. Shimizu, H. Chujo, J.H. Moon, and J. Terao Efficiency of absorption and metabolic conversion of quercetin and its glucosides in human intestinal cell line Caco-2 Arch. Biochem. Biophys. 384 2000 391 397 (Pubitemid 32012816)
16. K. Murota, S. Shimizu, S. Miyamoto, T. Izumi, A. Obata, M. Kikuchi, and J. Terao Unique uptake and transport of isoflavone aglycones by human intestinal caco-2 cells: comparison of isoflavonoids and flavonoids J. Nutr. 132 2002 1956 1961 (Pubitemid 34742884)
17. S.L. Peng, G. Zhang, Y.X. He, X.L. Wang, P.C. Leung, K.S. Leung, and L. Qin Epimedium-derived flavonoids promote osteoblastogenesis and suppress adipogenesis in bone marrow stromal cells while exerting an anabolic effect on osteoporotic bone Bone 45 2009 534 544
18. L. Qin, G. Zhang, W.Y. Hung, Y.Y. Shi, P.C. Leung, and K.S. Leung Phytoestrogen-rich formula "XLGB" prevents OVX-induced deterioration of musculoskeletal tissues at hip in old rats J. Bone Miner. Metab. 23 2005 55 61
19. I.R. Reid Anti-resorptive therapies for osteoporosis Semin. Cell Dev. Biol. 19 2008 473 478
20. D. Seidlova-Wuttke, H. Jarry, and W. Wuttke Pure estrogenic effect of benzophenone-2 (BP2) but not of bisphenol A (BPA) and dibutylphtalate (DBP) in uterus, vagina and bone Toxicology 205 2004 103 112 (Pubitemid 39349157)
21. A.L. Tong, L.L. Chen, and G.Z. Ding Progress of mechanism of osteoblastic bone formation Chin. J. Osteoporos. 5 1999 60 64
22. P. Trouillas, P. Marsal, A. Svobodova, J. Vostalova, R. Gazak, J. Hrbac, P. Sedmera, V. Kren, R. Lazzaroni, J.L. Duroux, and D. Walterova Mechanism of the antioxidant action of silybin and 2,3-dehydrosilybin flavonolignans: a joint experimental and theoretical study J. Phys. Chem. A 112 2008 1054 1063 (Pubitemid 351288191)
23. X.L. Wang, N.L. Wang, H. Gao, G. Zhang, L. Qin, M.S. Wong, and X.S. Yao Phenylpropanoid and flavonoids from osteoprotective fraction of Drynaria fortunei J. Nat. Prod. 24 2010 1206 1213
24. X.L. Wang, N.L. Wang, Y. Zhang, H. Gao, W.Y. Pang, M.S. Wong, G. Zhang, L. Qin, and X.S. Yao Effects of eleven flavonoids from the osteoprotective fraction of Drynaria fortunei (KUNZE) J. SM. on osteoblastic proliferation using an osteoblast-like cell line Chem. Pharm. Bull. 56 2008 46 51
25. M. Wei, Z. Yang, P. Li, Y. Zhang, and W.C. Sse Anti-osteoporosis activity of naringin in the retinoic acid-induced osteoporosis model Am. J. Chin. Med. 35 2007 663 667 (Pubitemid 47307704)
26. R.W. Wong, and A.B. Rabie Effect of naringin on bone cells J. Orthop. Res. 24 2006 2045 2050 (Pubitemid 44717966)
27. R.W. Wong, and A.B. Rabie Systemic effect of crude extract from rhizome of Drynaria fortunei on bone formation in mice Phytother. Res. 20 2006 313 315
28. R.W. Wong, A.B. Rabie, M. Bendeus, and U. Hagg The effects of Rhizoma Curculiginis and Rhizoma Drynariae extracts on bones Chin. Med. 2 2007 13
29. Y.M. Xie, D.H. Ju, and J.N. Zhao Effect of osteopractic total flavone on bone mineral density and bone histomorphometry in ovariectomized rats Zhongguo Zhong Yao Za Zhi 29 2004 343 346
30. D.W. Zhang, Y. Cheng, N.L. Wang, J.C. Zhang, M.S. Yang, and X.S. Yao Effects of total flavonoids and flavonol glycosides from Epimedium koreanum Nakai on the proliferation and differentiation of primary osteoblasts Phytomedicine 15 2008 55 61 (Pubitemid 350297899)
31. G. Zhang, L. Qin, W.Y. Hung, Y.Y. Shi, P.C. Leung, H.Y. Yeung, and K.S. Leung Flavonoids derived from herbal Epimedium Brevicornum Maxim prevent OVX-induced osteoporosis in rats independent of its enhancement in intestinal calcium absorption Bone 38 2006 818 825 (Pubitemid 44498593)
32. G. Zhang, L. Qin, H. Sheng, K.W. Yeung, H.Y. Yeung, W.H. Cheung, J. Griffith, C.W. Chan, K.M. Lee, and K.S. Leung Epimedium-derived phytoestrogen exert beneficial effect on preventing steroid-associated osteonecrosis in rabbits with inhibition of both thrombosis and lipid-deposition Bone 40 2007 685 692 (Pubitemid 46187235)
33. G. Zhang, L. Qin, and Y.Y. Shi Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone loss in late postmenopausal women: a 24-month randomized, double-blind and placebo-controlled trial J. Bone Miner. Res. 22 2007 1072 1079 (Pubitemid 351343696)
34. P. Zhang, K.R. Dai, S.G. Yan, W.Q. Yan, C. Zhang, D.Q. Chen, B. Xu, and Z.W. Xu Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell Eur. J. Pharmacol. 607 2009 1 5
35. P. Zhao, Y.J. Zhang, H. Yamamato, and C.R. Yang Recent advance on the chemistry, bioactivity and biosythesis of prenylated flavonoids from sophora flavecenes Nat. Prod. Res. 16 2004 172 178 (Pubitemid 38977751)
36. Q. Zhou Clinical application of Drynaria in orthopedics and traumatology J. Tradit. Chin. Orthop. Traumatol. 15 2003 59
37. O. Zierau, S. Gester, P. Schwab, P. Metz, S. Kolba, M. Wulf, and G. Vollmer Estrogenic activity of the phytoestrogens naringenin, 6-(1,1-dimethylallyl)naringenin and 8-prenylnaringenin Planta Med. 68 2002 449 451 (Pubitemid 34606690)