Ome on the range: Altitude adaptation, positive selection, and himalayan genomics

High Altitude Medicine and Biology

Volumn 12, Issue 2, 2011, Pages 133-139

  MacInnis, Martin J ^a   Rupert, Jim L ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

adaptation; EGLN1; EPAS1; evolution; genomics; high altitude; Tibetan

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 2ALPHA;

ALTITUDE ACCLIMATIZATION; ARTICLE; CHINA; ERYTHROPOIESIS; EVOLUTIONARY ADAPTATION; GENE FREQUENCY; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC SELECTION; GENETIC VARIABILITY; GENOMICS; HAPLOTYPE MAP; HUMAN; HYPOXEMIA; POPULATION GENETICS; PRIORITY JOURNAL;

ADAPTATION, BIOLOGICAL; ALTITUDE; ANOXIA; ASIAN CONTINENTAL ANCESTRY GROUP; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; GENOME-WIDE ASSOCIATION STUDY; HUMANS; PROCOLLAGEN-PROLINE DIOXYGENASE; SELECTION, GENETIC; TIBET;

EID: 79959917359     PISSN: 15270297     EISSN: 15578682     Source Type: Journal    
DOI: 10.1089/ham.2010.1090     Document Type: Article

References (16)

1. Aldenderfer M.S. (2011)Peopling the Tibetan Plateau: Insights from Archaeology. High Alt. Med. Biol. 12:141-147.
2. Ashburner M., Ball C.A., Blake J.A., Botstein D., Butler H., Cherry J.M., Davis A.P., Dolinski K., Dwight S.S., Eppig J.T., et al. (2000)Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat. Genet. 25(1):25-29. (Pubitemid 30257031)
3. Beall C.M., Brittenham G.M., Strohl K.P., Blangero J., Williams- Blangero S., Goldstein M.C., Decker M.J., Vargas E., Villena M., Soria R., et al. (1998)Hemoglobin concentration of highaltitude Tibetans and Bolivian Aymara. Am. J. Phys. Anthropol. 106(3):385-400. (Pubitemid 28345752)
4. Beall C.M., Cavalleri G.L., Deng L., Elston R.C., Gao Y., Knight J., Li C., Li J.C, Liang Y., McCormack M., et al. (2010)Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders. Proc. Natl. Acad. Sci. USA. 107(25):11459-11464.
5. Bigham A., Bauchet M., Pinto D., Mao X., Akey J.M., Mei R., Scherer S.W., Julian C.G., Wilson M.J., Lopez Herraez D., et al. (2010)Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data. PLoS Genet. 6(9).
6. Innan H., and Kondrashov F. (2010)The evolution of gene duplications: classifying and distinguishing between models. Nat. Rev. 11(2):97-108.
7. Moore L.G., Shriver M., Bemis L., Hickler B., Wilson., Brutsaert T., Parra E., and Vargas E. (2004)Maternal adaptation to high-altitude pregnancy: an experiment of nature: a review. Placenta. 25 Suppl A:S60-S71. (Pubitemid 38514959)
8. O'Rourke J.F., Tian Y.M., Ratcliffe P.J., and Pugh C.W. (1999). Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor- 1alpha. J. Biol. Chem. 274(4):2060-2071.
9. Peng Y., Yang Z., Zhang H., Cui C., Qi X., Luo X., Tao X., Wu T., Chen H., Shi H., et al. (2010)Genetic variations in Tibetan populations and high altitude adaptation at the Himalayas. Mol. Biol. Evol. Oct. 20. [epub ahead of print].
10. Pritchard J.K., and Di Rienzo A. (2010)Adaptation: not by sweeps alone. Nat. Rev. 11(10):665-667.
11. Simonson T.S., Yang Y., Huff C.D., Yun H., Qin G., Witherspoon D.J., Bai Z., Lorenzo F.R., Xing J., Jorde L.B., et al. (2010). Genetic evidence for high-altitude adaptation in Tibet. Science. 329(5987):72-75.
12. Thomas P.D., Campbell M.J., Kejariwal A., Mi H., Karlak B., Daverman R., Diemer K., Muruganujan A., and Narechania A. (2003)PANTHER: a library of protein families and subfamilies indexed by function. Genome Res.13(9):2129-2141. (Pubitemid 37161770)
13. Tissot van Patot M. C., Gassman G. (2011)Hypoxia: Adapting to high altitude by mutating HIF-2a. High Alt. Med. Biol. 12:157-167.
14. Wills C. J. (2011)Rapid recent human evolution and the accumulation of balanced genetic polymorphisms. High Alt. Med. Biol 12:149-155.
15. Xu S., Li S., Yang Y., Tan J., Lou H., Jin W., Yang L., Pan X., Wang J., Shen Y., et al. (2010)A genome-wide search for signals of high altitude adaptation in Tibetans. Mol. Biol. Evol. Oct. 2 [epub ahead of print].
16. Yi X., Liang Y., Huerta-Sanchez E., Jin X., Cuo Z.X., Pool J.E., Xu X., Jiang H., Vinckenbosch N., Korneliussen T.S, et al. (2010). Sequencing of 50 human exomes reveals adaptation to high altitude. Science. 329(5987):75-78.