Multiple loci modulate opioid therapy response for cancer pain

Clinical Cancer Research

Volumn 17, Issue 13, 2011, Pages 4581-4587

  Galvan, Antonella ^a   Skorpen, Frank ^b   Klepstad, Pål ^b,c   Knudsen, Anne Kari ^b   Fladvad, Torill ^b   Falvella, Felicia S ^a   Pigni, Alessandra ^a   Brunelli, Cinzia ^a   Caraceni, Augusto ^a,b   Kaasa, Stein ^b,d   Dragani, Tommaso A ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c Department of Anaesthesiology and Emergency Medicine ^*  (Norway)

^d TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

OPIATE;

ADULT; AGED; ANALGESIA; ARTICLE; CANCER PAIN; CANCER PATIENT; CONTROLLED STUDY; DNA DETERMINATION; DRUG RESPONSE; FEMALE; GENE; GENE FUNCTION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROMODULATION; PAIN THRESHOLD; PRIORITY JOURNAL; RHBDF2 GENE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; ANALGESICS, OPIOID; FEMALE; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION STUDIES; GENETIC LOCI; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; PAIN; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; SERINE PROTEASES; TREATMENT OUTCOME;

EID: 79959906110     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-10-3028     Document Type: Article

References (14)

1. Riley J, Ross JR, Rutter D, Wells AU, Goller K, du Bois R, et al. No pain relief from morphine? Individual variation in sensitivity to morphine and the need to switch to an alternative opioid in cancer patients. Support Care Cancer 2006;14:56-64.
2. Klepstad P, Kaasa S, Cherny N, Hanks G, de Conno FResearch Steering Committee of the EAPC. Pain and pain treatments in European palliative care units. A cross-sectional survey from the European Association for Palliative Care Research Network. Palliat Med 2005;19:477-84.
3. Klepstad P. Pharmacogenetic considerations in the treatment of cancer pain. In: Cancer pain: assessment and management. 2nd ed. New York: Cambridge University Press; 2010. p. 180-94.
4. Skorpen F, Laugsand EA, Klepstad P, Kaasa S. Variable response to opioid treatment: any genetic predictors within sight? Palliat Med 2008;22:310-27.
5. Andersen S, Skorpen F. Variation in the COMT gene: implications for pain perception and pain treatment. Pharmacogenomics 2009;10:669-84.
6. Walter C, Lotsch J. Meta-analysis of the relevance of the OPRM1 118A>G genetic variant for pain treatment. Pain 2009;146:270-5.
7. Knudsen AK, Brunelli C, Kaasa S, Apolone G, Corli O, Montanari M, et al. Which variables are associated with pain intensity and treatment response in advanced cancer patients?-implications for a future classification system for cancer pain. Eur J Pain 2011;15:320-7.
8. Daut RL, Cleeland CS, Flanery RC. Development of the Wisconsin brief pain questionnaire to assess pain in cancer and other diseases. Pain 1983;17:197-210. (Pubitemid 13012221)
9. Holen JC, Lydersen S, Klepstad P, Loge JH, Kaasa S. The Brief Pain Inventory: pain's interference with functions is different in cancer pain compared with noncancer chronic pain. Clin J Pain 2008;24:219-25. (Pubitemid 351640919)
10. Galvan A, Falvella FS, Frullanti E, Spinola M, Incarbone M, Nosotti M, et al. Genome-wide association study in discordant sibships identifies multiple inherited susceptibility alleles linked to lung cancer. Carcinogenesis 2010;31:462-5.
11. Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009;4:44-57.
12. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007;81:559-75. (Pubitemid 47330214)
13. Macgregor S, Zhao ZZ, Henders A, Nicholas MG, Montgomery GW, Visscher PM. Highly cost-efficient genome-wide association studies using DNA pools and dense SNP arrays. Nucleic Acids Res 2008;36:e35.
14. Bosse Y, Bacot F, Montpetit A, Rung J, Qu HQ, Engert JC, et al. Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans. Hum Genet 2009;125:305-18.