Deiodination of thyroid hormones by iodothyronine deiodinase mimics: Does an increase in the reactivity alter the regioselectivity?

Journal of the American Chemical Society

Volumn 133, Issue 26, 2011, Pages 9980-9983

  Manna, Debasish ^a   Mugesh, Govindasamy ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AMINO GROUP; CLOSE PROXIMITY; CYS RESIDUES; DEIODINATION; FUNCTIONAL MIMICS; IODOTHYRONINE; NUCLEOPHILIC REACTIVITY; ORGANOSELENIUM COMPOUNDS; THYROID HORMONES;

SELENIUM COMPOUNDS;

HORMONES;

3,3' DIIODOTHYRONINE; CYSTEINE; IODIDE PEROXIDASE; IODOTHYRONINE DEIODINASE; LIOTHYRONINE; NUCLEOPHILE; THYROID HORMONE; THYROXINE; UNCLASSIFIED DRUG;

ARTICLE; DEIODINATION; ENZYME ACTIVE SITE; ENZYME MECHANISM; NUCLEOPHILICITY;

BIOMIMETIC MATERIALS; HALOGENATION; IODIDE PEROXIDASE; ORGANOSELENIUM COMPOUNDS; STEREOISOMERISM; SUBSTRATE SPECIFICITY; SULFHYDRYL COMPOUNDS; THYROID HORMONES;

EID: 79959901642     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja201657s     Document Type: Article

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