Optimal construction and delivery of dual-functioning lentiviral vectors for type i collagen-suppressed chondrogenesis in synovium-derived mesenchymal stem cells

Pharmaceutical Research

Volumn 28, Issue 6, 2011, Pages 1338-1348

  Zhang, Feng ^a   Yao, Yongchang ^a,b   Zhou, Ruijie ^a   Su, Kai ^a   Citra, Fudiman ^a   Wang, Dong An ^a,b  

^a Nanyang Technological University   (Singapore)

^b SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

chondrogenesis; dual functioning lentiviral vector; synovial mesenchymal stem cells (SMSCs); TGF 3; type I collagen

Indexed keywords

AGGRECAN; ALGINIC ACID; COLLAGEN TYPE 1; COLLAGEN TYPE 2; GLYCOSAMINOGLYCAN; LENTIVIRUS VECTOR; MESSENGER RNA; SHORT HAIRPIN RNA; TRANSFORMING GROWTH FACTOR BETA3;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL VIABILITY; CHONDROGENESIS; CONTROLLED STUDY; DNA SEQUENCE; DRUG TARGETING; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE CASSETTE; GENE EXPRESSION; HYDROGEL; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STEM CELL; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SWINE; SYNOVIUM; UPREGULATION; VIRAL GENE DELIVERY SYSTEM;

AGGRECANS; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CHONDROGENESIS; COLLAGEN TYPE I; COLLAGEN TYPE II; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GLYCOSAMINOGLYCANS; LENTIVIRUS; MESENCHYMAL STEM CELLS; RNA, SMALL INTERFERING; SWINE; SYNOVIAL MEMBRANE; TRANSFORMING GROWTH FACTOR BETA3; UP-REGULATION;

EID: 79959891088     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0305-5     Document Type: Article

References (29)

1. RM Schulzand A Bader 2007 Cartilage tissue engineering and bioreactor systems for the cultivation and stimulation of chondrocytes Eur Biophys J. 36 539 568 10.1007/s00249-007-0139-1 (Pubitemid 46628646)
2. Buckwalter JA. Articular cartilage injuries. Clin Orthop Relat Res. 2002;21-37. (Pubitemid 35006577)
3. J Fan RR Varshney L Ren D Cai DA Wang 2009 Synovium-derived mesenchymal stem cells: a new cell source for musculoskeletal regeneration Tissue Eng Part B Rev. 15 75 86 19196118 10.1089/ten.teb.2008.0586 1:CAS:528:DC%2BD1MXivVKisrw%3D
4. CK Chuang LY Sung SM Hwang WH Lo HC Chen YC Hu 2007 Baculovirus as a new gene delivery vector for stem cell engineering and bone tissue engineering Gene Ther. 14 1417 1424 17637796 10.1038/sj.gt.3302996 1:CAS:528:DC%2BD2sXhtVCkurfJ (Pubitemid 47423741)
5. J Hao RR Varshney DA Wang 2009 Engineering osteogenesis and chondrogenesis with gene-enhanced therapeutic cells Curr Opin Mol Ther. 11 404 410 19649985 1:CAS:528:DC%2BC3cXnt1Knsrg%3D
6. JS Park DG Woo HN Yang HJ Lim HM Chung KH Park 2008 Heparin-bound transforming growth factor-beta3 enhances neocartilage formation by rabbit mesenchymal stem cells Transplantation. 85 589 596 18347539 10.1097/TP. 0b013e3181639b3a 1:CAS:528:DC%2BD1cXjt1Sls74%3D
7. RR Varshney, R Zhou, J Hao, SS Yeo, WH Chooi, J Fan, DA Wang: Chondrogenesis of synovium-derived mesenchymal stem cells in gene-transferred co-culture system. Biomaterials. 31: 6876-91.
8. R Mayne MS Vail PM Mayne EJ Miller 1976 Changes in type of collagen synthesized as clones of chick chondrocytes grow and eventually lose division capacity Proc Natl Acad Sci U S A. 73 1674 1678 1064040 10.1073/pnas.73.5.1674 1:CAS:528:DyaE28XktFOmtbY%3D
9. A Yokoyama I Sekiya K Miyazaki S Ichinose Y Hata T Muneta 2005 In vitro cartilage formation of composites of synovium-derived mesenchymal stem cells with collagen gel Cell Tissue Res. 322 289 298 16001268 10.1007/s00441-005-0010- 6 1:CAS:528:DC%2BD2MXht1Gru7zE (Pubitemid 41677645)
10. Zhang F, Yao Y, Hao J, Zhou R, Liu C, Gong Y, Wang DA. A dual-functioning adenoviral vector encoding both transforming growth factor-beta3 and shRNA silencing type I collagen: construction and controlled release for chondrogenesis. J Control Release. 142:70-7.
11. Y Yao C Wang RR Varshney DA Wang 2009 Antisense makes sense in engineered regenerative medicine Pharm Res. 26 263 275 19015958 10.1007/s11095-008-9772-3 1:CAS:528:DC%2BD1cXhtlyjtLvO
12. S Brantl 2002 Antisense-RNA regulation and RNA interference Biochim Biophys Acta. 1575 15 25 12020814 1:CAS:528:DC%2BD38XjvVaqur8%3D (Pubitemid 34521772)
13. JA Spector BJ Mehrara JS Luchs JA Greenwald PJ Fagenholz PB Saadeh DS Steinbrech MT Longaker 2000 Expression of adenovirally delivered gene products in healing osseous tissues Ann Plast Surg. 44 522 528 10805304 10.1097/00000637-200044050-00011 1:STN:280:DC%2BD3c3mtlSmtg%3D%3D (Pubitemid 30252964)
14. F Liand RI Mahato 2009 Bipartite vectors for co-expression of a growth factor cDNA and short hairpin RNA against an apoptotic gene J Gene Med. 11 764 771 10.1002/jgm.1357
15. Yao Y, Zhang F, Zhou R, Su K, Fan J, Wang DA. Effects of combinational adenoviral vector-mediated TGF beta 3 transgene and shRNA silencing type I collagen on articular chondrogenesis of synovium-derived mesenchymal stem cells. Biotechnol Bioeng. 106:818-28.
16. C De Bari F Dell'Accio P Tylzanowski FP Luyten 2001 Multipotent mesenchymal stem cells from adult human synovial membrane Arthritis Rheum. 44 1928 1942 11508446 10.1002/1529-0131(200108)44:8<1928::AID-ART331>3.0. CO;2-P (Pubitemid 32758241)
17. GA Ameer TA Mahmood R Langer 2002 A biodegradable composite scaffold for cell transplantation J Orthop Res. 20 16 19 11853084 10.1016/S0736-0266(01) 00074-2 1:CAS:528:DC%2BD38XitFOjsrY%3D (Pubitemid 34071416)
18. RL Sah YJ Kim JY Doong AJ Grodzinsky AH Plaas JD Sandy 1989 Biosynthetic response of cartilage explants to dynamic compression J Orthop Res. 7 619 636 2760736 10.1002/jor.1100070502 1:STN:280:DyaL1MzktF2ruw%3D%3D (Pubitemid 19208087)
19. RW Farndale DJ Buttle AJ Barrett 1986 Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue Biochim Biophys Acta. 883 173 177 3091074 1:CAS:528:DyaL28Xls1yhsrs%3D (Pubitemid 16027978)
20. LE Freed JC Marquis A Nohria J Emmanual AG Mikos R Langer 1993 Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers J Biomed Mater Res. 27 11 23 8380593 10.1002/jbm. 820270104 1:CAS:528:DyaK3sXhsFCnurs%3D (Pubitemid 23002763)
21. C Wilson HJ Bellen WJ Gehring 1990 Position effects on eukaryotic gene expression Annu Rev Cell Biol. 6 679 714 2275824 10.1146/annurev.cb.06.110190. 003335 1:CAS:528:DyaK3MXpsFyntw%3D%3D
22. P Wang J Yang A Ishihama AJ Pittard 1998 Demonstration that the TyrR protein and RNA polymerase complex formed at the divergent P3 promoter inhibits binding of RNA polymerase to the major promoter, P1, of the aroP gene of Escherichia coli J Bacteriol. 180 5466 5472 9765583 1:CAS:528:DyaK1cXmvVWiu7g%3D (Pubitemid 28471548)
23. BP Callen KE Shearwin JB Egan 2004 Transcriptional interference between convergent promoters caused by elongation over the promoter Mol Cell. 14 647 656 15175159 10.1016/j.molcel.2004.05.010 1:CAS:528:DC%2BD2cXltlGntL4%3D (Pubitemid 38739086)
24. S Adhyaand M Gottesman 1982 Promoter occlusion: transcription through a promoter may inhibit its activity Cell. 29 939 944 10.1016/0092-8674(82)90456-1 (Pubitemid 12027915)
25. EM Prescottand NJ Proudfoot 2002 Transcriptional collision between convergent genes in budding yeast Proc Natl Acad Sci U S A. 99 8796 8801 10.1073/pnas.132270899 (Pubitemid 34693638)
26. V Epshtein F Toulme AR Rahmouni S Borukhov E Nudler 2003 Transcription through the roadblocks: the role of RNA polymerase cooperation EMBO J. 22 4719 4727 12970184 10.1093/emboj/cdg452 1:CAS:528:DC%2BD3sXnt1KjsLk%3D (Pubitemid 37162908)
27. Y Han YB Lin W An J Xu HC Yang K O'Connell D Dordai JD Boeke JD Siliciano RF Siliciano 2008 Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough Cell Host Microbe. 4 134 146 18692773 10.1016/j.chom.2008.06.008 1:CAS:528:DC%2BD1cXhtVGqsbvL
28. X Hu S Eszterhas N Pallazzi EE Bouhassira J Fields O Tanabe SA Gerber M Bulger JD Engel M Groudine S Fiering 2007 Transcriptional interference among the murine beta-like globin genes Blood. 109 2210 2216 17077320 10.1182/blood-2006-06-029868 1:CAS:528:DC%2BD2sXjtFCjsrw%3D (Pubitemid 46348225)
29. AM Bhosaleand JB Richardson 2008 Articular cartilage: structure, injuries and review of management Br Med Bull. 87 77 95 10.1093/bmb/ldn025