Thiophenyl oxime-derived phosphonates as nano-molar class C beta-lactamase inhibitors reducing MIC of imipenem against Pseudomonas aeruginosa and Acinetobacter baumannii

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 14, 2011, Pages 4363-4365

  Tan, Qiang ^a   Ogawa, Aimie M ^a   Raghoobar, Susan L ^a   Wisniewski, Douglas ^a   Colwell, Lawrence ^a   Park, Young Whan ^a   Young, Katherine ^a   Hermes, Jeffrey D ^a   Dininno, Frank P ^a   Hammond, Milton L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Acinetobacter baumannii; Beta lactamase inhibitors; Class C; Imipenem; MIC; Oxime; Phosphonate; Pseudomonas aeruginosa; Thiophenyl

Indexed keywords

ANTIBIOTIC AGENT; BETA LACTAMASE AMPC; BETA LACTAMASE INHIBITOR; IMIPENEM; THIOPHENYL OXIME PHOSPHONATE DERIVATIVE; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; AREA UNDER THE CURVE; ARTICLE; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG POTENCY; DRUG POTENTIATION; DRUG SYNTHESIS; ENTEROBACTER CLOACAE; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PSEUDOMONAS AERUGINOSA;

ACINETOBACTER BAUMANNII; ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; DRUG RESISTANCE, BACTERIAL; ENZYME INHIBITORS; IMIPENEM; MICROBIAL SENSITIVITY TESTS; OXIMES; PHOSPHONIC ACIDS; PSEUDOMONAS AERUGINOSA; THIOPHENES;

ACINETOBACTER BAUMANNII; ENTEROBACTER CLOACAE; MUS; PSEUDOMONAS AERUGINOSA;

EID: 79959870774     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.122     Document Type: Article

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