Synthesis and evaluation of highly potent GABAA receptor antagonists based on gabazine (SR-95531)

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 14, 2011, Pages 4252-4254

  Iqbal, Favaad ^a   Ellwood, Ryan ^a   Mortensen, Martin ^a   Smart, Trevor G ^a   Baker, James R ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Antagonist; GABAA antagonists; GABAA receptor; Gabazine; Pyridazines

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; FAMIRAPRINE;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; PATCH CLAMP;

GABA-A RECEPTOR ANTAGONISTS; PYRIDAZINES; RECEPTORS, GABA-A;

EID: 79959869096     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.05.067     Document Type: Article

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