Rapid determination of gefitinib and its main metabolite, O-desmethyl gefitinib in human plasma using liquid chromatography-tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 22, 2011, Pages 2155-2161

  Wang, Ling Zhi ^a   Lim, Michelle Yi Xiu ^b   Chin, Tan Min ^a,c   Thuya, Win Lwin ^a   Nye, Pei Ling ^a   Wong, Andrea ^c   Chan, Sui Yung ^b   Goh, Boon Cher ^a,c   Ho, Paul C ^b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

Author keywords

Gefitinib; Human plasma; LC MS MS; O Desmethyl gefitinib

Indexed keywords

ANALYTES; BIOANALYTICAL TOOLS; CHROMATOGRAPHIC SEPARATIONS; CLINICAL TRIAL; COLUMN EFFLUENT; COMBINATION THERAPY; GEFITINIB; HUMAN PLASMAS; ISOCRATIC ELUTION; LC-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MOBILE PHASE; NON SMALL CELL LUNG CANCER; PHASE I; POSITIVE MODE; RAPID DETERMINATION; RUNTIMES; TRIPLE-QUADRUPOLE MASS SPECTROMETER;

ACETONITRILE; EFFLUENTS; ELECTROSPRAY IONIZATION; FORMIC ACID; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLISM; METABOLITES; PATIENT TREATMENT; PLASMA (HUMAN);

CHROMATOGRAPHY;

ACETONITRILE; DRUG METABOLITE; FORMIC ACID; GEFITINIB; HYDROXYCHLOROQUINE; O DESMETHYL GEFITINIB; UNCLASSIFIED DRUG;

ACCURACY; ADVANCED CANCER; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG METABOLISM; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LUNG NON SMALL CELL CANCER; PHASE 1 CLINICAL TRIAL; POSITIVE ION ELECTROSPRAY; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; QUANTITATIVE ANALYSIS; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; LEAST-SQUARES ANALYSIS; QUINAZOLINES; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 79959864280     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.05.056     Document Type: Article

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