-
1
-
-
0018967595
-
Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoin
-
BOXENBAUM, H., 1980, Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: extrapolation of data to benzodiazepines and phenytoin. Journal of Pharmacokinetics and Biopharmaceutics, 8, 165-176.
-
(1980)
Journal of Pharmacokinetics and Biopharmaceutics
, vol.8
, pp. 165-176
-
-
Boxenbaum, H.1
-
2
-
-
0036016088
-
Anti-epidermal growth factor receptor drugs in cancer therapy
-
CIARDIELLO, F. and TORTORA, G., 2002, Anti-epidermal growth factor receptor drugs in cancer therapy. Expert Opinion on Investigational Drugs, 11, 755-768.
-
(2002)
Expert Opinion on Investigational Drugs
, vol.11
, pp. 755-768
-
-
Ciardiello, F.1
Tortora, G.2
-
3
-
-
0032850677
-
Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
-
COBLEIGH, M. A., VOGEL, C. L., TRIPATHY, D., ROBERT, N. J., SCHOLL, S., FEHRENBACHER, L., WOLTER, J. M., PATON, V., SHAK, S., LIEBERMAN, G. and SLAMON, D. J., 1999, Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. Journal of Clinical Oncology, 17, 2639-2648.
-
(1999)
Journal of Clinical Oncology
, vol.17
, pp. 2639-2648
-
-
Cobleigh, M.A.1
Vogel, C.L.2
Tripathy, D.3
Robert, N.J.4
Scholl, S.5
Fehrenbacher, L.6
Wolter, J.M.7
Paton, V.8
Shak, S.9
Lieberman, G.10
Slamon, D.J.11
-
4
-
-
0025360796
-
Pharmacologically guided phase I clinical trials based upon preclinical drug development
-
COLLINS, J. M., GRIESHABER, C. K. and CHABNER, B. A., 1990, Pharmacologically guided phase I clinical trials based upon preclinical drug development. Journal of the National Cancer Institute, 82, 1321-1326.
-
(1990)
Journal of the National Cancer Institute
, vol.82
, pp. 1321-1326
-
-
Collins, J.M.1
Grieshaber, C.K.2
Chabner, B.A.3
-
5
-
-
0023196582
-
erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells
-
DI FIORE, P. P., PIERCE, J. H., KRAUS, M. H., SEGATTO, O., KING, C. R. and AARONSON, S. A., 1987, erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science, 237, 178-182.
-
(1987)
Science
, vol.237
, pp. 178-182
-
-
Di Fiore, P.P.1
Pierce, J.H.2
Kraus, M.H.3
Segatto, O.4
King, C.R.5
Aaronson, S.A.6
-
6
-
-
0026077157
-
The EGF receptor system as a target for antitumor therapy
-
ENNIS, B. W., LIPPMAN, M. E. and DICKSON, R. B., 1991, The EGF receptor system as a target for antitumor therapy. Cancer Investigation, 9, 553-562.
-
(1991)
Cancer Investigation
, vol.9
, pp. 553-562
-
-
Ennis, B.W.1
Lippman, M.E.2
Dickson, R.B.3
-
7
-
-
0028937815
-
Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype
-
FONTANINI, G., VIGNATI, S., BIGINI, D., MUSSI, A., LUCCHI, H., ANGELETTI, C. A., PINGITORE, R., PEPE, S., BASOLO, F. and BEVILACQUA, G., 1995, Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype. European Journal of Cancer, 31A, 178-183.
-
(1995)
European Journal of Cancer
, vol.31 A
, pp. 178-183
-
-
Fontanini, G.1
Vignati, S.2
Bigini, D.3
Mussi, A.4
Lucchi, H.5
Angeletti, C.A.6
Pingitore, R.7
Pepe, S.8
Basolo, F.9
Bevilacqua, G.10
-
8
-
-
0012381722
-
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
-
FUKUOKA, M., YANO, S., GIACCONE, G., TAMURA, T., NAKAGAWA, K., DOUILLARD, J. Y., NISHIWAKI, Y., VANSTEENKISTE, J., KUDOH, S., RISCHIN, D., EEK, R., HORAI, T., NODA, K., TAKATA, I., SMIT, E., AVERBUCH, S., MACLEOD, A., FEYEREISLOVA, A, DONG, R. P. and BASELGA, J., 2003, Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. Journal of Clinical Oncology, 21, 2237-2246.
-
(2003)
Journal of Clinical Oncology
, vol.21
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
Tamura, T.4
Nakagawa, K.5
Douillard, J.Y.6
Nishiwaki, Y.7
Vansteenkiste, J.8
Kudoh, S.9
Rischin, D.10
Eek, R.11
Horai, T.12
Noda, K.13
Takata, I.14
Smit, E.15
Averbuch, S.16
Macleod, A.17
Feyereislova, A.18
Dong, R.P.19
Baselga, J.20
more..
-
9
-
-
0026028343
-
Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers
-
GULLICK, W. J., 1991, Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers. British Medical Bulletin, 47, 87-98.
-
(1991)
British Medical Bulletin
, vol.47
, pp. 87-98
-
-
Gullick, W.J.1
-
10
-
-
0037106377
-
Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors: Results of a phase I trial
-
HERBST, R. S., MADDOX, A. M., ROTHENBERG, M. L., SMALL, E. J., RUBIN, E. H., BASELGA, J., ROJO, F., HONG, W. K., SWAISLAND, H., AVERBUCH, S. D., OCHS, J. and LORUSSO, P. M., 2002, Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors: results of a phase I trial. Journal of Clinical Oncology, 20, 3815-3825.
-
(2002)
Journal of Clinical Oncology
, vol.20
, pp. 3815-3825
-
-
Herbst, R.S.1
Maddox, A.M.2
Rothenberg, M.L.3
Small, E.J.4
Rubin, E.H.5
Baselga, J.6
Rojo, F.7
Hong, W.K.8
Swaisland, H.9
Averbuch, S.D.10
Ochs, J.11
Lorusso, P.M.12
-
11
-
-
0026535916
-
Transcriptional regulation of rat P-450 2C gene subfamily members by the sexually dimorphic pattern of growth hormone secretion
-
LEGRAVEREND, C., MODE, A., WESTIN, S., STROM, A., EGUCHI, H., ZAPHIROPOULOS, P. G. and GUSTAFSSON, J. A., 1992, Transcriptional regulation of rat P-450 2C gene subfamily members by the sexually dimorphic pattern of growth hormone secretion. Molecular Endocrinology, 6, 259-266.
-
(1992)
Molecular Endocrinology
, vol.6
, pp. 259-266
-
-
Legraverend, C.1
Mode, A.2
Westin, S.3
Strom, A.4
Eguchi, H.5
Zaphiropoulos, P.G.6
Gustafsson, J.A.7
-
12
-
-
0030482184
-
Sex-dependent pharmacokinetics of indinavir: In vivo and in vitro evidence
-
LIN, J. H., CHIBA, M., CHEN, I. W., NISHIME, J. A. and VASTAG, K. J., 1996, Sex-dependent pharmacokinetics of indinavir: in vivo and in vitro evidence. Drug Metabolism and Disposition, 24, 1298-1306.
-
(1996)
Drug Metabolism and Disposition
, vol.24
, pp. 1298-1306
-
-
Lin, J.H.1
Chiba, M.2
Chen, I.W.3
Nishime, J.A.4
Vastag, K.J.5
-
13
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
LYNCH, T. J., BELL, D. W., SORDELLA, R., GURUBHAGAVATULA, S., OKIMOTO, R. A., BRANNIGAN, B. W., HARRIS, P. L., HASERLAT, S. M., SUPKO, J. G., HALUSKA, F. G., LOUIS, D. N., CHRISTIANI, D. C., SETTLEMAN, J. and HABER, D. A., 2004, Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. New England Journal of Medicine, 350, 2129-2139.
-
(2004)
New England Journal of Medicine
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Haserlat, S.M.8
Supko, J.G.9
Haluska, F.G.10
Louis, D.N.11
Christiani, D.C.12
Settleman, J.13
Haber, D.A.14
-
14
-
-
10644261348
-
Metabolic disposition of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in rat, dog and man
-
in press
-
McKILLOP, D., HUTCHISON, M., PARTRIDGE, E. A., BUSHBY, N., COOPER, C. M. F., CLARKSON-JONES, J. A., HERRON, W. and SWAISLAND, H. C., 2004, Metabolic disposition of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in rat, dog and man. Xenobiotica (in press).
-
(2004)
Xenobiotica
-
-
Mckillop, D.1
Hutchison, M.2
Partridge, E.A.3
Bushby, N.4
Cooper, C.M.F.5
Clarkson-Jones, J.A.6
Herron, W.7
Swaisland, H.C.8
-
15
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
PAEZ, J. G., JANNE, P. A., LEE, J. C., TRACY, S., GREULICH, H., GABRIEL, S., HERMAN, P., KAYE, F. J., LINDEMAN, N., BOGGON, T. J., NAOKI, K., SASAKI, H., FUJII, Y., ECK, M. J., SELLERS, W. R., JOHNSON, B. E. and MEYERSON, M., 2004, EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science, 304, 1497-1500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
Herman, P.7
Kaye, F.J.8
Lindeman, N.9
Boggon, T.J.10
Naoki, K.11
Sasaki, H.12
Fujii, Y.13
Eck, M.J.14
Sellers, W.R.15
Johnson, B.E.16
Meyerson, M.17
-
16
-
-
0036569870
-
ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: Results of a phase I trial
-
RANSON, M., HAMMOND, L. A., FERRY, D., KRIS, M., TULLO, A., MURRAY, P. I., MILLER, V., AVERBUCH, S., OCHS, J., MORRIS, C., FEYEREISLOVA, A., SWAISLAND, H. and ROWINSKY, E. K., 2002, ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: results of a phase I trial. Journal of Clinical Oncology, 20, 2240-2250.
-
(2002)
Journal of Clinical Oncology
, vol.20
, pp. 2240-2250
-
-
Ranson, M.1
Hammond, L.A.2
Ferry, D.3
Kris, M.4
Tullo, A.5
Murray, P.I.6
Miller, V.7
Averbuch, S.8
Ochs, J.9
Morris, C.10
Feyereislova, A.11
Swaisland, H.12
Rowinsky, E.K.13
-
17
-
-
0022374645
-
Presence of epidermal growth factor receptor as an indicator of poor prognosis in patients with breast cancer
-
SAINSBURY, J. R., MALCOLM, A. J., APPLETON, D. R., FARNDON, J. R. and HARRIS, A. L., 1985, Presence of epidermal growth factor receptor as an indicator of poor prognosis in patients with breast cancer. Journal of Clinical Pathology, 38, 1225-1228.
-
(1985)
Journal of Clinical Pathology
, vol.38
, pp. 1225-1228
-
-
Sainsbury, J.R.1
Malcolm, A.J.2
Appleton, D.R.3
Farndon, J.R.4
Harris, A.L.5
-
18
-
-
0028955388
-
Epidermal growth factor-related peptides and their receptors in human malignancies
-
SALOMON, D. S., BRANDT, R., CIARDIELLO, F. and NORMANNO, N., 1995, Epidermal growth factor-related peptides and their receptors in human malignancies. Critical Reviews in Oncology-Hematology, 19, 183-232.
-
(1995)
Critical Reviews in Oncology-Hematology
, vol.19
, pp. 183-232
-
-
Salomon, D.S.1
Brandt, R.2
Ciardiello, F.3
Normanno, N.4
-
19
-
-
0034489914
-
Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase
-
SIROTNAK, F. M., ZAKOWSKI, M. F., MILLER, V. A., SCHER, H. I. and KRIS, M. G., 2000, Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase. Clinical Cancer Research, 6, 4885-4892.
-
(2000)
Clinical Cancer Research
, vol.6
, pp. 4885-4892
-
-
Sirotnak, F.M.1
Zakowski, M.F.2
Miller, V.A.3
Scher, H.I.4
Kris, M.G.5
-
20
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
SLAMON, D. J., CLARK, G. M., WONG, S. G., LEVIN, W. J., ULLRICH, A. and McGUIRE, W. L., 1987, Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science, 235, 177-182.
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
Levin, W.J.4
Ullrich, A.5
Mcguire, W.L.6
-
21
-
-
0030846063
-
Pharmacokinetics and disposition of the oxytocin receptor antagonist L-368,899 in rats and dogs
-
THOMPSON, K. L., VINCENT, S. H., MILLER, R. R., COLLETTI, A. E., ALVARO, R. F., WALLACE, M. A., FEENEY, W. P. and CHIU, S. H., 1997, Pharmacokinetics and disposition of the oxytocin receptor antagonist L-368,899 in rats and dogs. Drug Metabolism and Disposition, 25, 1113-1118.
-
(1997)
Drug Metabolism and Disposition
, vol.25
, pp. 1113-1118
-
-
Thompson, K.L.1
Vincent, S.H.2
Miller, R.R.3
Colletti, A.E.4
Alvaro, R.F.5
Wallace, M.A.6
Feeney, W.P.7
Chiu, S.H.8
-
22
-
-
0030742593
-
New targets for therapeutic attack
-
WAKELING, A. E., BARKER, A. J., DAVIES, D. H., BROWN, D. S., GREEN, L. R., CARTLIDGE, S. A. and WOODBURN, J. R., 1997, New targets for therapeutic attack. Endocrine-related Cancer, 4, 351-355.
-
(1997)
Endocrine-related Cancer
, vol.4
, pp. 351-355
-
-
Wakeling, A.E.1
Barker, A.J.2
Davies, D.H.3
Brown, D.S.4
Green, L.R.5
Cartlidge, S.A.6
Woodburn, J.R.7
-
23
-
-
0037109014
-
ZD1839 (Iressa): An orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy
-
WAKELING, A. E., GUY, S. P., WOODBURN, J. R., ASHTON, S. E., CURRY, B. J., BARKER, A. J. and GIBSON, K. H., 2002, ZD1839 (Iressa): an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Research, 62, 5749-5754.
-
(2002)
Cancer Research
, vol.62
, pp. 5749-5754
-
-
Wakeling, A.E.1
Guy, S.P.2
Woodburn, J.R.3
Ashton, S.E.4
Curry, B.J.5
Barker, A.J.6
Gibson, K.H.7
-
24
-
-
0025267223
-
Pituitary regulation of the male-specific steroid 6 beta-hydroxylase P-450 2a (gene product IIIA2) in adult rat liver. Suppressive influence of growth hormone and thyroxine acting at a pretranslational level
-
WAXMAN, D. J., RAM, P. A., NOTANI, G., LEBLANC, G. A., ALBERTA, J. A., MORRISSEY, J. J. and SUNDSETH, S. S., 1990, Pituitary regulation of the male-specific steroid 6 beta-hydroxylase P-450 2a (gene product IIIA2) in adult rat liver. Suppressive influence of growth hormone and thyroxine acting at a pretranslational level. Molecular Endocrinology, 4, 447-454.
-
(1990)
Molecular Endocrinology
, vol.4
, pp. 447-454
-
-
Waxman, D.J.1
Ram, P.A.2
Notani, G.3
Leblanc, G.A.4
Alberta, J.A.5
Morrissey, J.J.6
Sundseth, S.S.7
-
25
-
-
0033063774
-
The epidermal growth factor receptor and its inhibition in cancer therapy
-
WOODBURN, J. R., 1999, The epidermal growth factor receptor and its inhibition in cancer therapy. Pharmacology and Therapeutics, 82, 241-250.
-
(1999)
Pharmacology and Therapeutics
, vol.82
, pp. 241-250
-
-
Woodburn, J.R.1
-
26
-
-
0027018017
-
Tyrosine kinase inhibitors
-
WORKMAN, P., BRUNTON, V. G. and ROBINS, D. J., 1992, Tyrosine kinase inhibitors. Seminars in Cancer Biology, 3, 369-381.
-
(1992)
Seminars in Cancer Biology
, vol.3
, pp. 369-381
-
-
Workman, P.1
Brunton, V.G.2
Robins, D.J.3
-
27
-
-
0023942517
-
Growth factor receptor tyrosine kinases
-
YARDEN, Y. and ULLRICH, A., 1988, Growth factor receptor tyrosine kinases. Annual Review of Biochemistry, 57, 443-478.
-
(1988)
Annual Review of Biochemistry
, vol.57
, pp. 443-478
-
-
Yarden, Y.1
Ullrich, A.2
|