Reduced thymic output, cell cycle abnormalities, and increased apoptosis of T lymphocytes in patients with cartilage-hair hypoplasia

Journal of Allergy and Clinical Immunology

Volumn 128, Issue 1, 2011, Pages 139-146

  De La Fuente, Miguel A ^a   Recher, Mike ^a   Rider, Nicholas L ^b   Strauss, Kevin A ^b,g   Morton, D Holmes ^b,g   Adair, Margaret ^c   Bonilla, Francisco A ^a   Ochs, Hans D ^d   Gelfand, Erwin W ^c   Pessach, Itai M ^a   Walter, Jolan E ^a   King, Alejandra ^e   Giliani, Silvia ^f   Pai, Sung Yun ^a   Notarangelo, Luigi D ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b CLINIC FOR SPECIAL CHILDREN   (United States)

^c DEPARTMENT OF MEDICINE   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^e HOSPITAL LUIS CALVO MACKENNA   (Chile)

^f UNIVERSITY OF BRESCIA   (Italy)

^g FRANKLIN AND MARSHALL COLLEGE   (United States)

Author keywords

apoptosis; Cartilage hair hypoplasia; cell cycle; immunodeficiency; RMRP; T lymphocytes; thymus

Indexed keywords

ALEMTUZUMAB; FLUDARABINE; MELPHALAN; RIBONUCLEASE; RNA COMPONENT OF THE MITOCHONDRIAL RNA PROCESSING ENDORIBONUCLEASE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CARTILAGE HAIR HYPOPLASIA; CARTILAGE HYPOPLASIA; CELL CYCLE; CELL MIGRATION; CELL PROLIFERATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENOTYPE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNE DEFICIENCY; MALE; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMUS FUNCTION;

ADOLESCENT; APOPTOSIS; CELL CYCLE; CELL SEPARATION; CHILD; CHILD, PRESCHOOL; FEMALE; FLOW CYTOMETRY; GENOTYPE; HAIR; HIRSCHSPRUNG DISEASE; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; INFANT; MALE; MUTATION; OSTEOCHONDRODYSPLASIAS; PHENOTYPE; POLYMERASE CHAIN REACTION; RNA, UNTRANSLATED; T-LYMPHOCYTES; THYMUS GLAND; YOUNG ADULT;

EID: 79959856336     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2011.03.042     Document Type: Article

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