Etiology of septicemia in children with acute leukemia: 9-year experience from a Children's Hospital in China

Journal of Pediatric Hematology/Oncology

Volumn 33, Issue 5, 2011, Pages

  Ye, Qing ^a   Xu, Xiaojun ^b   Zheng, Yi ^a   Chen, Xuejun ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Antibiotic prophylaxis; etiology; pediatric

Indexed keywords

AMIKACIN; AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; CEFAZOLIN; CEFEPIME; CEFOTETAN; CEFOXITIN; CEFTAZIDIME; CEFTRIAXONE; CHLORAMPHENICOL; CLINDAMYCIN; COTRIMOXAZOLE; ERYTHROMYCIN; FLUCONAZOLE; GENTAMICIN; IMIPENEM; LEVOFLOXACIN; LINEZOLID; MOXIFLOXACIN; NITROFURANTOIN; PENICILLIN G; PIPERACILLIN PLUS TAZOBACTAM; RIFAMPICIN; SULFAMETHOXAZOLE; SULPERAZON; TETRACYCLINE; TOBRAMYCIN; VANCOMYCIN;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATE; BLOOD CULTURE; BLOODSTREAM INFECTION; CHILD; CHINA; COAGULASE NEGATIVE STAPHYLOCOCCUS; ESCHERICHIA COLI; FEMALE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HOSPITAL PATIENT; HUMAN; IN VITRO STUDY; INCIDENCE; KLEBSIELLA PNEUMONIAE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MYCOSIS; NEUTROPHIL COUNT; PATHOGENESIS; PNEUMOCYSTIS PNEUMONIA; PRESCHOOL CHILD; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RETROSPECTIVE STUDY; SEPTICEMIA; TREATMENT OUTCOME;

ACUTE DISEASE; ADOLESCENT; BACTERIAL INFECTIONS; CHILD; CHILD, HOSPITALIZED; CHILD, PRESCHOOL; CHINA; ESCHERICHIA COLI INFECTIONS; FEMALE; HUMANS; INCIDENCE; INFANT; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; LEUKEMIA; MALE; RETROSPECTIVE STUDIES; SEPSIS; STAPHYLOCOCCAL INFECTIONS;

EID: 79959853170     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0b013e31821ba92c     Document Type: Article

References (26)

1. Gafter-Gvili A, Fraser A, Paul M, et al. Meta-analysis: Antibiotic prophylaxis reduces mortality in neutropenic patients. Ann Intern Med. 2005;142:979-995. (Pubitemid 40840313)
2. Bucaneve G, Micozzi A, Menichetti F, et al. Levofloxacin to prevent bacterial infection in patients with cancer and neutropenia. N Engl J Med. 2005;353:977-987. (Pubitemid 41262332)
3. Cullen M, Steven N, Billingham L, et al. Antibacterial prophylaxis after chemotherapy for solid tumors and lymphomas. N Engl J Med. 2005;353:988-998. (Pubitemid 41262333)
4. Tang YM, Xu XJ, Song H, et al. Long-term outcome of childhood acute lymphoblastic leukemia treated in China. Pediatr Blood Cancer. 2008;51:380-386.
5. Xu XJ, Tang YM, Song H, et al. Long-term outcome of childhood acute myeloid leukemia in developing country: Experience from a children's hospital in China. Leuk Lymphoma. 2010;51:2262-2269.
6. Raja NS, Parratt D, Meyers M. Blood culture contamination in a district general hospital in the UK: A 1-year study. Healthcare Infection. 2009;14:95-100.
7. Uslan DZ, Crane SJ, Steckelberg JM et al. Age- and sexassociated trends in bloodstream infection: A population-based study in Olmsted County, Minnesota. Arch Intern Med. 2007;167:834-839. (Pubitemid 46658343)
8. Zhanel GG, Decorby M, Nichol KA, et al. Characterization of methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci and extended-spectrum beta-lactamase-producing Escherichia coli in intensive care units in Canada: Results of the Canadian National Intensive Care Unit (CAN-ICU) study (2005-2006). Can J Infect Dis Med Microbiol. 2008;19: 243-249.
9. Chen CY, Tsay W, Tang JL, et al. Epidemiology of bloodstream infections in patients with haematological malignancies with and without neutropenia. Epidemiol Infect. 2010;138:1044-1051.
10. Zaidi AK, Thaver D, Ali SA, et al. Pathogens associated with sepsis in newborns and young infants in developing countries. Pediatr Infect Dis J. 2009;28(1 Suppl):S10-S18.
11. Bilal NE, Gedebou M, Al-Ghamdi S. Endemic nosocomial infections and misuse of antibiotics in a maternity hospital in Saudi Arabia. APMIS. 2002;110:140-147. (Pubitemid 34327152)
12. Fauci AS, Braunwald E, Kasper DL, et al. Infections in patients with cancer (pg 533-41); Harrison's Principles of Internal Medicine. 17th ed. U.S.A: McGraw-Hill; 2008:533-541.
13. Young LS. Sepsis syndrome. In: Mandell GL, Bennett JE, Dolin R. eds. Principles and Practice of Infectious Diseases. 5th ed. Philadelphia: Churchill Livingstone; 2000:806-819.
14. Bush K. Bench-to-bedside review: The role of beta-lactamases in antibiotic-resistant Gram-negative infections. Crit Care. 2010;14:224.
15. Jacoby GA, Munoz-Price LS. The new beta-lactamases. N Engl J Med. 2005;352:380-391.
16. Wong-Beringer A, Hindler J, Loeloff M, et al. Molecular correlation for the treatment outcomes in bloodstream infections caused by Escherichia coli and Klebsiella pneumoniae with reduced susceptibility to ceftazidime. Clin Infect Dis. 2002; 34:135-146. (Pubitemid 34028343)
17. Paterson DL, Ko WC, Von Gottberg A, et al. Outcome of cephalosporin treatment for serious infections due to apparently susceptible organisms producing extended-spectrum b-lactamases: Implications for the clinical microbiology laboratory. J. Clin. Microbiol. 2001;39:2206-2212. (Pubitemid 32531482)
18. Patterson JE. Extended-spectrum beta-lactamases. Semin Respir Infect. 2000;15:299-307.
19. Segal BH, Baden LR, Brown AE, et al. Prevention and treatment of cancer related infections. J Natl Compr Canc Netw. 2008;6:122-174. (Pubitemid 351340523)
20. Hughes WT, Armstrong D, Bodey GP, et al. Guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis. 2002;34:730-751. (Pubitemid 34194843)
21. Paul M, Yahav D, Fraser A, et al. Empirical antibiotic monotherapy for febrile neutropenia: Systematic review and meta-analysis of randomized controlled trials. J Antimicrob Chemother. 2006;57:176-189. (Pubitemid 43160156)
22. Bow EJ, Rotstein C, Noskin GA, et al. A randomized, openlabel, multicenter comparative study of the efficacy and safety of piperacillin- tazobactam and cefepime for the empirical treatment of febrile neutropenic episodes in patients with hematologic malignancies. Clin Infect Dis. 2006;43:447-459. (Pubitemid 44157153)
23. Harter C, Schulze B, Goldschmidt H, et al. Piperacillin/tazobactam vs ceftazidime in the treatment of neutropenic fever in patients with acute leukemia or following autologous peripheral blood stem cell transplantation: A prospective randomized trial. Bone Marrow Transplant. 2006;37:373-379. (Pubitemid 43250471)
24. Paul M, Borok S, Fraser A, et al. Additional anti-Grampositive antibiotic treatment for febrile neutropenic cancer patients. Cochrane Database Syst Rev. 2005;20:CD003914.
25. Tunkel AR, Sepkowitz KA. Infections caused by viridans streptococci in patients with neutropenia. Clin Infect Dis. 2002;34:1524-1529. (Pubitemid 34553713)
26. Tjan-Heijnen VC, Postmus PE, Ardizzoni A, et al. Reduction of chemotherapy-induced febrile leucopenia by prophylactic use of ciprofloxacin and roxithromycin in small-cell lung cancer patients: An EORTC double-blind placebo-controlled Phase III study. Ann Oncol. 2001;12:1359-1368. (Pubitemid 33100239)