Saffron: A repository of medicinal properties

Journal of Medicinal Plants Research

Volumn 5, Issue 11, 2011, Pages 2131-2135

  Wani, Bilal Ahmad ^a   Hamza, Amina Khan Rouf ^a   Mohiddin, F A ^a  

^a UNIVERSITY OF KASHMIR   (India)

Author keywords

Medicine; Properties; Saffron; Stigma

Indexed keywords

ALCOHOL; CROCETIN; CROCIN; CROCUS SATIVUS EXTRACT; IMIPRAMINE; KAEMPFEROL; WATER;

ANTICONVULSANT ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTINOCICEPTION; BLOOD PRESSURE REGULATION; CORONARY ARTERY DISEASE; DEGENERATIVE DISEASE; DEPRESSION; DIABETES MELLITUS; DIET SUPPLEMENTATION; DRUG CYTOTOXICITY; DRUG EFFECT; EHRLICH ASCITES TUMOR; EYE BLOOD FLOW; GENOTOXICITY; HUMAN; HYPERGLYCEMIA; HYPERTENSION; ISCHEMIA; LEARNING DISORDER; LONG TERM POTENTIATION; LYMPHOMA; MEDICINAL PLANT; MEMORY DISORDER; MUTAGENIC ACTIVITY; NONHUMAN; PAIN; PARKINSONISM; PHYTOCHEMISTRY; PISTIL STIGMA; RETINA MACULA AGE RELATED DEGENERATION; RETINOPATHY; REVIEW; SAFFRON; SARCOMA 180; SEIZURE; SOCIAL LEARNING; SPICE; STOMACH MUCOSA LESION; STOMACH PROTECTION;

CROCUS SATIVUS;

EID: 79959845538     PISSN: 19960875     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Review

References (52)

1. Abdullaev FI (1993). Biological effects of saffron. Biofactors 4: 83-86.
2. Abdullaev FI (2002). Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus). Exp. Biol. Med., 227: 20-25.
3. Abdullaev FI, Caballero-Ortega H, Riveron-Nigrete L, Pereda-miranda R, Rivera-Luna, R, Manuel Hernandez J, Perez-Lopez I, Espinosa- Aguirre JJ (2002). In vitro evaluation of chemopreventive potential of saffron. Rev. Invest. Clin., 54: 430-436.
4. Abdullaev FI, Riveron-Negrete L, Caballero-Ortega H, Manuel Hernandez J, Perez-Lopez I, Pereda-Miranda R, Espinosa-Aguirre JJ (2003). Use of in vitro assays to assess the potential antigenotoxic and cytotoxic effects of saffron (Crocus sativus L.). Toxicol. In Vitro, 17: 731-736.
5. Abdullaev FI (2003). Use of in vitro assays to assess the potential antigenotoxic and cytotoxic effects of saffron (Crocus sativus L.). Toxicol. in vitro 17: 751.
6. Abdullaev FI (2004). Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. Cancer Det. Preven., 28: 426-432.
7. Abe K, Saito H (2000). Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation. Phytother. Res., 14: 149-152.
8. Abe K (1999). Saffron extract prevents acetaldehyde-induced inhibition of long-term potentiation in the rat dentate gyrus in vivo. Brain Res., 851: 287-289.
9. Ahmad AS (2005). Biological Properties and Medicinal Use of Saffron. Pharmacol. Biochem. Behavior., 81: 805-813.
10. Al-Mofleh LA, Alhaider AA, Mossa JS, Al-Sohaibani MO, Qureshi S, Rafatullah S (2006). Antigastric Ulcer Studies on 'Saffron' Crocus sativus L. in Rats Pakistan J. Biol. Sci., 9: 1009-1013.
11. Arranz N, Haza, AI, Garcia A, Rafter J, Morales P (2007). Protective effect of vitamin C towards N-nitrosamineinduced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay. Toxicol. In Vitro, 21: 1311-1317.
12. Assimopoulou AN, Sinakos Z, Papageorgiou VP (2005). Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents. Phytother. Res., 19: 997-1000.
13. Bors W, Saran M, Michel C (1982). Radical intermediates involved in the bleaching of the carotenoid crocin. Hydroxyl radicals, superoxide anions and hydrated electrons. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med., 41: 493-501.
14. Chang VC, Lin YL, Lee MJ, Show SJ, Wang CJ (1996). Inhibitory effect of crocetin on benzopyrene genotoxicity and neoplastic transformation in C3H1OT1=2 cells. Anticancer Res., 765: 3603-3608.
15. Daly ES (1998). Protective effect of cysteine and vitamine E, Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in rat. J. Pharm. Belg., 53: 87-93.
16. Escribano J, Alonso GL, Coca-Prados M, Fernandez JA (1996). Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Lett., 100: 23-30.
17. Fatehi M, Rashidabady T, Fatehi-Hassanabad Z (2003). Effects of Crocus sativus petals' extract on rat blood pressure. J. Ethnopharmacol., 84: 199.
18. Garcia-Olmo DC, Riese HH, Escribano J, Ontanon J, Fernandez JA, Atienzar M, Garcia-Olmo DC (1999). Effects of long term treatment of colon adenocarcinoma with crocin, a carotenoid from saffron (Crocus sativus): an experimental study in the rat. Nutr. Cancer, 35: 120-126.
19. Harper D (2001). "Saffron", Online Etymology Dictionary,http://www.etymoline.com/index.php?search=saffron&searchmode=none.
20. Hosseinzadeh H, Karimi G, Niapoor M (2004). Antidepressant effects of Crocus sativus stigma extracts and its constituents, crocin and safranal, in mice. Acta Hortic., 650: 435-445.
21. Hosseinzadeh H, Khosravan V (2002). Anticonvulsant effects of aqueous and ethanolic extracts of Crocus sativus L. stigmas in mice. Arch Iran Med., 5, 44-47.
22. Hosseinzadeh H, Modaghegh MH, Saffari Z (2009). Crocus Sativus L. (saffron) extract and its active constituents (crocin and safranal) on ischemia-reperfusion in rat skeletal muscle. Evid. Based Complement Alternat. Med., 6: 343-350.
23. Hosseinzadeh H, Sadeghnia HR (2007). Effect of safranal, a constituent of Crocus sativus (saffron), on methyl methanesulfonate (MMS)- induced DNA damage in mouse organs: an alkaline single-cell gel electrophoresis (comet) assay. DNA Cell Biol., 26: 841-846.
24. Hosseinzadeh H, Younesi HM (2002). Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacol., 2: 1-8.
25. Hosseinzadeh H, Khosravan V (2002). Anticonvulsant effects aqueous and ethanolic extracts of Crocus sativus L. stigmas in mice. Arch. Irn. Med., 5: 44-47.
26. Hosseinzadeh H, Younesi H (2002). Petal and stigma extracts of Crocus sativus L.have antinociceptive and anti-inflammatory effects in mice. BMC. Pharmacol., 2: 1-8.
27. Jagdeep SD, Prasad DN, Avinish CT, Gupta R (2009). Role of traditional medicine in Neuropsycohharmocology; Asian J. Pharm. Clin. Res., 2: 72-76
28. Katzer G (2001). "Saffron (Crocus sativus L.)", Gernot Katzer's Spice pages.
29. Kaya B (2003). Antigenotoxic effect of ascorbic acid on mutagenic dose of three alkylating agents. Turk. J. Biol., 27: 241-246.
30. Khan N, Afaq F, Mukhtar H (2008). Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxid Redox Signal, 10: 475-510.
31. Kumar V (2006). The secret Benefits of Spices and Condiments. Sterling, p. 103.
32. Mathew B (1999). Botany, Taxonomy and cytology of C. Sativus L. and its allies. In: M.Negbi (ed) Saffron. Hardwood Academic Publishers, Amsterdam.
33. Martin G (2002). Evaluation of the developmental toxicity of crocetin on Xenopus.
34. Morjani H (1990). Growth inhibitin and induction of crythroid diferentiation activity by crocin, dimethylcrocetine and carotene on K- 562 tumor cells. Anticancer Res., 10: 1398-1406.
35. Nair SC, Kurumboor SK, Hasegawa JH (1995). Saffron chemoprevention in biology and medicine: a review. Cancer Biother., 10: 257-264.
36. Nair SC, Varghese CD, Pannikar KR, Kurumboor SK, Parathod RK (1994). Effect of saffron on vitamin A levels and its antitumor activity on the growth of solid tumors in mice. Int. J. Clin. Pharmacol., 32: 105-114.
37. Nair SC (1991). Antitumor activity of saffron (Crocus sativus). Cancer Lett., 57: 109 114.
38. Nair SC (1994). Effects of saffron on vitamin A levels and its antitumor activity on the growth of solid tumor in mice. Int. J. Pharm., 32: 105-114.
39. Nair SC (1995). Saffron chemoprevention in biology and medicine: a review. Cancer Biother., 10: 257-264.
40. Nair SC, Panikkar KR, Parathod RK (1993). Protective effects of crocetin on bladder cytotoxicity induced by cyclophosphamide. Cancer Biother., 8: 339-343
41. Pham TQ, Cormier F, Farnworth E, Tong VH, Van-Calsteren MR (2000). Antioxidant properties of crocin from Gardenia jasminoides Ellis and study of the reactions of crocin with linoleic acid and crocin with oxygen. J. Agric. Food Chem., 48: 1455-1461.
42. Premkumar K, Abraham SK, Santhiya ST, Gopinath PM, Ramesh A (2001). Inhibition of genotoxicity by saffron (Crocus sativus L.) in mice. Drug Chem. Toxicol., 24: 421-428.
43. Premkumar K, Abraham, SK, Santhiya, ST, Ramesh A (2003). Protective effects of saffron (Crocus sativus L.) on genotoxinsinduced oxidative stress in Swiss albino mice. Phytother. Res., 17: 614-617.
44. Premkumar K, Thirunavukkarasu C, Abraham, SK, Santhiya ST, Ramesh A (2006). Protective effect of saffron (Crocus sativus L.) aqueous extract against genetic damage induced by anti-tumor agents in mice. Hum. Exp. Toxicol., 25: 79-84.
45. Rios JL, Recio MC, Ginger RM, Manz S (1996). An update review of saffron and its active constituents. Phytother. Res., 10: 189-193.
46. Salomi MJ, Nair SC, Panikkar KR (1991). Cytotoxicity and non mutagenicity of Nigella sativa and saffron (Crocus sativus) in vitro. Proc. Ker. Sci. Congr., 5: 244.
47. Salomi MJ (1991). Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice. Nutr. Cancer, 16(1): 67-72.
48. Sigura M, Saito H, Abe K (1995). Etanol extract of Crocus sativus L. antagonizes the inhibitory action of ethanol on hippocampal long-term potentiation in vivo. Phytother. Res., 9: 100-104.
49. Tarantilis PA, Morjani H, Polissou M, Manafait M (1994). Inhibition of growth and induction of differentiation of promyelocytic leukemia (HL- 60) by carotenoids from Crocus sativus L. Anticancer Res., 14: 1913-1918.
50. Verma SK, Bordia A (1998). Antioxidant property of saffron in man. Indian J. Med. Sci., 52(5): 205-207.
51. Xuan B (1999). Effects of crocin analogs on ocular flow and retinal function. J. Ocul. Pharmacol. Ther., 15(2): 143-52.
52. Zhang Y, Shoyama Y, Sugiura M, Saito H (1994). Effect of Crocus sativus L. On the ethanol-induced impairment of passive avoidance performances in mice. Biol. Pharm. Bull., 17: 217-221.