메뉴 건너뛰기




Volumn 9, Issue 5, 2011, Pages 364-373

Alemtuzumab: What is the secret to safe therapy?

Author keywords

Alemtuzumab; Chronic lymphocytic leukemia; Fludarabine; Minimal residual disease; Monoclonal antibody

Indexed keywords

ALEMTUZUMAB; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; FLUDARABINE; RITUXIMAB; VALACICLOVIR; VALGANCICLOVIR;

EID: 79959840618     PISSN: 15430790     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (9)

References (45)
  • 1
    • 77949479415 scopus 로고    scopus 로고
    • State-of-the-art treatment of chronic lymphocytic leukemia
    • Hallek M. State-of-the-art treatment of chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program. 2009;440-449.
    • (2009) Hematology Am Soc Hematol Educ Program , pp. 440-449
    • Hallek, M.1
  • 2
    • 79959813697 scopus 로고    scopus 로고
    • Campath (alemtuzumab) full prescribing information. Cambridge, MA: Genzyme Corporation
    • Campath (alemtuzumab) full prescribing information. Cambridge, MA: Genzyme Corporation; 2009.
    • (2009)
  • 3
    • 0037092951 scopus 로고    scopus 로고
    • Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study
    • Keating MJ, Flinn I, Jain V, et al. Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study. Blood. 2002;99:3554-3561.
    • (2002) Blood , vol.99 , pp. 3554-3561
    • Keating, M.J.1    Flinn, I.2    Jain, V.3
  • 4
    • 37649004407 scopus 로고    scopus 로고
    • Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia
    • Hillmen P, Skotnicki AB, Robak T, et al. Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia. J Clin Oncol. 2007;25:5616-5623.
    • (2007) J Clin Oncol , vol.25 , pp. 5616-5623
    • Hillmen, P.1    Skotnicki, A.B.2    Robak, T.3
  • 5
    • 27244451794 scopus 로고    scopus 로고
    • Fludarabine in combination with alemtuzumab is effective and feasible in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: Results of a phase II trial
    • Elter T, Borchmann P, Schulz H, et al. Fludarabine in combination with alemtuzumab is effective and feasible in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: results of a phase II trial. J Clin Oncol. 2005;23:7024-7031.
    • (2005) J Clin Oncol , vol.23 , pp. 7024-7031
    • Elter, T.1    Borchmann, P.2    Schulz, H.3
  • 6
    • 0037085770 scopus 로고    scopus 로고
    • Campath-1H and fludarabine in combination are highly active in refractory chronic lymphocytic leukemia
    • Kennedy B, Rawstron A, Carter C, et al. Campath-1H and fludarabine in combination are highly active in refractory chronic lymphocytic leukemia. Blood. 2002;99:2245-2247.
    • (2002) Blood , vol.99 , pp. 2245-2247
    • Kennedy, B.1    Rawstron, A.2    Carter, C.3
  • 7
    • 11144357712 scopus 로고    scopus 로고
    • Management guidelines for use of alemtuzumab in B-cell chronic lymphocytic leukemia
    • Keating M, Coutre S, Rai K, et al. Management guidelines for use of alemtuzumab in B-cell chronic lymphocytic leukemia. Clin Lymphoma. 2004;4:220-227.
    • (2004) Clin Lymphoma , vol.4 , pp. 220-227
    • Keating, M.1    Coutre, S.2    Rai, K.3
  • 8
    • 70450265546 scopus 로고    scopus 로고
    • Management guidelines for the use of alemtuzumab in chronic lymphocytic leukemia
    • Osterborg A, Foa R, Bezares RF, et al. Management guidelines for the use of alemtuzumab in chronic lymphocytic leukemia. Leukemia. 2009;23:1980-1988.
    • (2009) Leukemia , vol.23 , pp. 1980-1988
    • Osterborg, A.1    Foa, R.2    Bezares, R.F.3
  • 10
    • 0030897222 scopus 로고    scopus 로고
    • Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia
    • Osterborg A, Dyer MJ, Bunjes D, et al. Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia. J Clin Oncol. 1997;15:1567-1574.
    • (1997) J Clin Oncol , vol.15 , pp. 1567-1574
    • Osterborg, A.1    Dyer, M.J.2    Bunjes, D.3
  • 11
    • 0042071567 scopus 로고    scopus 로고
    • Phase II study of alemtuzumab in chronic lymphoproliferative disorders
    • Ferrajoli A, O'Brien SM, Cortes JE, et al. Phase II study of alemtuzumab in chronic lymphoproliferative disorders. Cancer. 2003;98:773-778.
    • (2003) Cancer , vol.98 , pp. 773-778
    • Ferrajoli, A.1    O'Brien, S.M.2    Cortes, J.E.3
  • 12
    • 11144357657 scopus 로고    scopus 로고
    • Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions
    • Lozanski G, Heerema NA, Flinn IW, et al. Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions. Blood. 2004;103:3278-3281.
    • (2004) Blood , vol.103 , pp. 3278-3281
    • Lozanski, G.1    Heerema, N.A.2    Flinn, I.W.3
  • 13
    • 69849107362 scopus 로고    scopus 로고
    • Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia: Clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group
    • Stilgenbauer S, Zenz T, Winkler D, et al. Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia: clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group. J Clin Oncol. 2009;27:3994-4001.
    • (2009) J Clin Oncol , vol.27 , pp. 3994-4001
    • Stilgenbauer, S.1    Zenz, T.2    Winkler, D.3
  • 14
    • 0037106502 scopus 로고    scopus 로고
    • Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine
    • Rai KR, Freter CE, Mercier RJ, et al. Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine. J Clin Oncol. 2002;20:3891-3897.
    • (2002) J Clin Oncol , vol.20 , pp. 3891-3897
    • Rai, K.R.1    Freter, C.E.2    Mercier, R.J.3
  • 15
    • 21144456107 scopus 로고    scopus 로고
    • Eradication of minimal residual disease in B-cell chronic lymphocytic leukemia after alemtuzumab therapy is associated with prolonged survival
    • Moreton P, Kennedy B, Lucas G, et al. Eradication of minimal residual disease in B-cell chronic lymphocytic leukemia after alemtuzumab therapy is associated with prolonged survival. J Clin Oncol. 2005;23:2971-2979.
    • (2005) J Clin Oncol , vol.23 , pp. 2971-2979
    • Moreton, P.1    Kennedy, B.2    Lucas, G.3
  • 16
    • 15244362778 scopus 로고    scopus 로고
    • A pilot study of low-dose subcutaneous alemtuzumab therapy for patients with chemotherapy-refractory chronic lymphocytic leukemia
    • Cortelezzi A, Pasquini MC, Sarina B, et al. A pilot study of low-dose subcutaneous alemtuzumab therapy for patients with chemotherapy-refractory chronic lymphocytic leukemia. Haematologica. 2005;90:410-412.
    • (2005) Haematologica , vol.90 , pp. 410-412
    • Cortelezzi, A.1    Pasquini, M.C.2    Sarina, B.3
  • 17
    • 70450267533 scopus 로고    scopus 로고
    • Low-dose subcutaneous alemtuzumab in refractory chronic lymphocytic leukaemia (CLL): Results of a prospective, single-arm multicentre study
    • Cortelezzi A, Pasquini MC, Gardellini A, et al. Low-dose subcutaneous alemtuzumab in refractory chronic lymphocytic leukaemia (CLL): results of a prospective, single-arm multicentre study. Leukemia. 2009;23:2027-2033.
    • (2009) Leukemia , vol.23 , pp. 2027-2033
    • Cortelezzi, A.1    Pasquini, M.C.2    Gardellini, A.3
  • 18
    • 0036683449 scopus 로고    scopus 로고
    • Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL)
    • Lundin J, Kimby E, Bjorkholm M, et al. Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL). Blood. 2002;100:768-773.
    • (2002) Blood , vol.100 , pp. 768-773
    • Lundin, J.1    Kimby, E.2    Bjorkholm, M.3
  • 19
    • 31444453579 scopus 로고    scopus 로고
    • Alemtuzumab induces caspase-independent cell death in human chronic lymphocytic leukemia cells through a lipid raft-dependent mechanism
    • Mone AP, Cheney C, Banks AL, et al. Alemtuzumab induces caspase-independent cell death in human chronic lymphocytic leukemia cells through a lipid raft-dependent mechanism. Leukemia. 2006;20:272-279.
    • (2006) Leukemia , vol.20 , pp. 272-279
    • Mone, A.P.1    Cheney, C.2    Banks, A.L.3
  • 20
    • 0027283918 scopus 로고
    • Efficient complement-mediated lysis of cells containing the CAMPATH-1 (CDw52) antigen
    • Xia MQ, Hale G, Waldmann H. Efficient complement-mediated lysis of cells containing the CAMPATH-1 (CDw52) antigen. Mol Immunol. 1993;30: 1089-1096.
    • (1993) Mol Immunol , vol.30 , pp. 1089-1096
    • Xia, M.Q.1    Hale, G.2    Waldmann, H.3
  • 21
    • 12744279711 scopus 로고    scopus 로고
    • Proapoptotic activity of alemtuzumab alone and in combination with rituximab or purine nucleoside analogues in chronic lymphocytic leukemia cells
    • Smolewski P, Szmigielska-Kaplon A, Cebula B, et al. Proapoptotic activity of alemtuzumab alone and in combination with rituximab or purine nucleoside analogues in chronic lymphocytic leukemia cells. Leuk Lymphoma. 2005;46: 87-100.
    • (2005) Leuk Lymphoma , vol.46 , pp. 87-100
    • Smolewski, P.1    Szmigielska-Kaplon, A.2    Cebula, B.3
  • 22
    • 76649142414 scopus 로고    scopus 로고
    • Analysis of minimal residual disease from the phase 2 multicenter study of subcutaneous alemtuzumab combined with fludarabine for treatment of relapsed/refractory B-cell chronic lymphocytic leukemia
    • ASH Annual Meeting Abstracts, Abstract 3111
    • Flowers C, Rosenthal H, Brown J, et al. Analysis of minimal residual disease from the phase 2 multicenter study of subcutaneous alemtuzumab combined with fludarabine for treatment of relapsed/refractory B-cell chronic lymphocytic leukemia. Blood (ASH Annual Meeting Abstracts). 2007;110:Abstract 3111.
    • (2007) Blood , pp. 110
    • Flowers, C.1    Rosenthal, H.2    Brown, J.3
  • 23
    • 77956205101 scopus 로고    scopus 로고
    • Improved progression-free survival (PFS) of alemtuzumab (CampathR, MabCampathR) plus fludarabine (FludaraR) versus fludarabine alone as second-line treatment of patients with B-cell chronic lymphocytic leukemia: Preliminary results from a phase III randomized trial
    • ASH Annual Meeting Abstracts, Abstract 537
    • Engert A, Gercheva L, Robak T, et al. Improved progression-free survival (PFS) of alemtuzumab (CampathR, MabCampathR) plus fludarabine (FludaraR) versus fludarabine alone as second-line treatment of patients with B-cell chronic lymphocytic leukemia: preliminary results from a phase III randomized trial. Blood (ASH Annual Meeting Abstracts). 2009;114:Abstract 537.
    • (2009) Blood , pp. 114
    • Engert, A.1    Gercheva, L.2    Robak, T.3
  • 24
    • 79959855156 scopus 로고    scopus 로고
    • Combined fludarabine, cyclophosphamide, and alemtuzumab (FCC), an active regimen for treated patients with chronic lymphocytic leukemia
    • ASH Annual Meeting Abstracts, Abstract 3133
    • Montillo M, Miqueleiz S, Tedeschi A, et al. Combined fludarabine, cyclophosphamide, and alemtuzumab (FCC), an active regimen for treated patients with chronic lymphocytic leukemia. Blood (ASH Annual Meeting Abstracts). 2007;110:Abstract 3133.
    • (2007) Blood , pp. 110
    • Montillo, M.1    Miqueleiz, S.2    Tedeschi, A.3
  • 25
    • 71649096001 scopus 로고    scopus 로고
    • Chemoimmunotherapy with fludarabine, cyclophosphamide and alemtuzumab in patients with relapsed/refractory CLL: Interim analysis of the CLL2L trial of the German CLL Study Group
    • ASH Annual Meeting Abstracts, Abstract 3170 and presented poster
    • Elter T, James R, Stilgenbauer S, Ritgen M, Hallek M, Engert A. Chemoimmunotherapy with fludarabine, cyclophosphamide and alemtuzumab in patients with relapsed/refractory CLL: interim analysis of the CLL2L trial of the German CLL Study Group. Blood (ASH Annual Meeting Abstracts). 2008;112:Abstract 3170 and presented poster.
    • (2008) Blood , pp. 112
    • Elter, T.1    James, R.2    Stilgenbauer, S.3    Ritgen, M.4    Hallek, M.5    Engert, A.6
  • 26
    • 77953446272 scopus 로고    scopus 로고
    • Chemoimmuno-therapy with fludarabine, cyclophosphamide and alemtuzumab (FC-Cam) in patients with relapsed or genetic high-risk CLL: Final analysis of the CLL2L trial of the German CLL Study Group
    • ASH Annual Meeting Abstracts, Abstract 209
    • Elter T, James R, Stilgenbauer S, et al. Chemoimmuno-therapy with fludarabine, cyclophosphamide and alemtuzumab (FC-Cam) in patients with relapsed or genetic high-risk CLL: final analysis of the CLL2L trial of the German CLL Study Group. Blood (ASH Annual Meeting Abstracts). 2009;114:Abstract 209.
    • (2009) Blood , pp. 114
    • Elter, T.1    James, R.2    Stilgenbauer, S.3
  • 27
    • 38049094162 scopus 로고    scopus 로고
    • Combined cyclophosphamide, fludarabine, alemtuzumab, and rituximab (CFAR), an active regimen for heavily treated patients with CLL
    • ASH Annual Meeting Abstracts, Abstract 31
    • Wierda WG, O'Brien S, Faderl S, et al. Combined cyclophosphamide, fludarabine, alemtuzumab, and rituximab (CFAR), an active regimen for heavily treated patients with CLL. Blood (ASH Annual Meeting Abstracts). 2006; 108:Abstract 31.
    • (2006) Blood , pp. 108
    • Wierda, W.G.1    O'Brien, S.2    Faderl, S.3
  • 28
    • 45149110164 scopus 로고    scopus 로고
    • Combined cyclophosphamide, fludarabine, alemtuzumab, and rituximab (CFAR), an active frontline regimen for high-risk patients with CLL
    • ASH Annual Meeting Abstracts, Abstract 628
    • Wierda WG, O'Brien S, Ferrajoli A, et al. Combined cyclophosphamide, fludarabine, alemtuzumab, and rituximab (CFAR), an active frontline regimen for high-risk patients with CLL. Blood (ASH Annual Meeting Abstracts). 2007;110:Abstract 628.
    • (2007) Blood , pp. 110
    • Wierda, W.G.1    O'Brien, S.2    Ferrajoli, A.3
  • 29
    • 77950308297 scopus 로고    scopus 로고
    • Immunochemotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) versus fludarabine (F), cyclophosphamide (C) and MabCampath (Cam) (FCCam) in previously untreated patients (pts) with advanced B-chronic lymphocytic leukemia (B-CLL): Experience on safety and efficacy within a randomised multicenter phase III trial of the French Cooperative Group on CLL and WM (FCGCLL/MW)
    • ASH Annual Meeting Abstracts, Abstract 538
    • Lepretre S, Aurran T, Mahe B, et al. Immunochemotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) versus fludarabine (F), cyclophosphamide (C) and MabCampath (Cam) (FCCam) in previously untreated patients (pts) with advanced B-chronic lymphocytic leukemia (B-CLL): experience on safety and efficacy within a randomised multicenter phase III trial of the French Cooperative Group on CLL and WM (FCGCLL/MW) and the "Groupe Ouest-est d'Etudes Des Leucemies Aigues et Autres Maladies du Sang" (GOELAMS): CLL2007FMP (for fit medically patients). Blood (ASH Annual Meeting Abstracts). 2009;114:Abstract 538.
    • (2009) Blood , pp. 114
    • Lepretre, S.1    Aurran, T.2    Mahe, B.3
  • 31
    • 79959840597 scopus 로고    scopus 로고
    • Polish Lymphoma Research Group Web site. Geisler C. HOVON68 CLL protocol: annual safety report 2008, Accessed April 4
    • Polish Lymphoma Research Group Web site. Geisler C. HOVON68 CLL protocol: annual safety report 2008. http://www.plrg.pl/images/stories/badania/hovon/HOVON68CLL_Annual_Safety_ Report_2008.pdf. Accessed April 4, 2010.
    • (2010)
  • 32
    • 0038724252 scopus 로고    scopus 로고
    • Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies
    • Faderl S, Thomas DA, O'Brien S, et al. Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies. Blood. 2003;101:3413-3415.
    • (2003) Blood , vol.101 , pp. 3413-3415
    • Faderl, S.1    Thomas, D.A.2    O'Brien, S.3
  • 33
    • 33746812059 scopus 로고    scopus 로고
    • Continuous infusion/subcutaneous alemtuzumab (Campath-1H) plus rituximab is active for patients with relapsed/ refractory chronic lymphocytic leukemia (CLL)
    • ASH Annual Meeting Abstracts, Abstract 2963
    • Faderl S, Ferrajoli A, Wierda W, et al. Continuous infusion/subcutaneous alemtuzumab (Campath-1H) plus rituximab is active for patients with relapsed/ refractory chronic lymphocytic leukemia (CLL). Blood (ASH Annual Meeting Abstracts). 2005;106:Abstract 2963.
    • (2005) Blood , pp. 106
    • Faderl, S.1    Ferrajoli, A.2    Wierda, W.3
  • 34
    • 8644274039 scopus 로고    scopus 로고
    • A pilot trial of rituximab and alemtuzumab combination therapy in patients with relapsed and/or refractory chronic lymphocytic leukemia (CLL)
    • Nabhan C, Patton D, Gordon LI, et al. A pilot trial of rituximab and alemtuzumab combination therapy in patients with relapsed and/or refractory chronic lymphocytic leukemia (CLL). Leuk Lymphoma. 2004;45:2269-2273.
    • (2004) Leuk Lymphoma , vol.45 , pp. 2269-2273
    • Nabhan, C.1    Patton, D.2    Gordon, L.I.3
  • 35
    • 62549086165 scopus 로고    scopus 로고
    • A phase II trial of alemtuzumab and rituximab in patients with previously untreated CLL
    • ASH Annual Meeting Abstracts, Abstract 2056
    • Frankfurt O, Hamilton E, Acharya S, Duffey S, Raji A, Rosen ST. A phase II trial of alemtuzumab and rituximab in patients with previously untreated CLL. Blood (ASH Annual Meeting Abstracts). 2007;110:Abstract 2056.
    • (2007) Blood , pp. 110
    • Frankfurt, O.1    Hamilton, E.2    Acharya, S.3    Duffey, S.4    Raji, A.5    Rosen, S.T.6
  • 36
    • 55749093568 scopus 로고    scopus 로고
    • Early treatment of high-risk chronic lymphocytic leukemia with alemtuzumab and rituximab
    • Zent CS, Call TG, Shanafelt TD, et al. Early treatment of high-risk chronic lymphocytic leukemia with alemtuzumab and rituximab. Cancer. 2008;113: 2110-2118.
    • (2008) Cancer , vol.113 , pp. 2110-2118
    • Zent, C.S.1    Call, T.G.2    Shanafelt, T.D.3
  • 37
    • 2942694373 scopus 로고    scopus 로고
    • Consolidation with alemtuzumab in patients with chronic lymphocytic leukemia (CLL) in first remission-experience on safety and efficacy within a randomized multicenter phase III trial of the German CLL Study Group (GCLLSG)
    • Wendtner CM, Ritgen M, Schweighofer CD, et al. Consolidation with alemtuzumab in patients with chronic lymphocytic leukemia (CLL) in first remission-experience on safety and efficacy within a randomized multicenter phase III trial of the German CLL Study Group (GCLLSG). Leukemia. 2004;18:1093-1101.
    • (2004) Leukemia , vol.18 , pp. 1093-1101
    • Wendtner, C.M.1    Ritgen, M.2    Schweighofer, C.D.3
  • 38
    • 57649088296 scopus 로고    scopus 로고
    • Consolidation with alemtuzumab improves progression-free survival in patients with chronic lymphocytic leukaemia (CLL) in first remission: Long-term follow-up of a randomized phase III trial of the German CLL Study Group (GCLLSG)
    • Schweighofer CD, Ritgen M, Eichhorst BF, et al. Consolidation with alemtuzumab improves progression-free survival in patients with chronic lymphocytic leukaemia (CLL) in first remission: long-term follow-up of a randomized phase III trial of the German CLL Study Group (GCLLSG). Br J Haematol. 2009;144: 95-98.
    • (2009) Br J Haematol , vol.144 , pp. 95-98
    • Schweighofer, C.D.1    Ritgen, M.2    Eichhorst, B.F.3
  • 39
    • 33744793781 scopus 로고    scopus 로고
    • Alemtuzumab as consolidation after a response to fludarabine is effective in purging residual disease in patients with chronic lymphocytic leukemia
    • Montillo M, Tedeschi A, Miqueleiz S, et al. Alemtuzumab as consolidation after a response to fludarabine is effective in purging residual disease in patients with chronic lymphocytic leukemia. J Clin Oncol. 2006;24:2337-2342.
    • (2006) J Clin Oncol , vol.24 , pp. 2337-2342
    • Montillo, M.1    Tedeschi, A.2    Miqueleiz, S.3
  • 40
    • 70350749633 scopus 로고    scopus 로고
    • Fludarabine followed by alemtuzumab consolidation for previously untreated chronic lymphocytic leukemia: Final report of Cancer and Leukemia Group B study 19901
    • Byrd JC, Peterson BL, Rai KR, et al. Fludarabine followed by alemtuzumab consolidation for previously untreated chronic lymphocytic leukemia: final report of Cancer and Leukemia Group B study 19901. Leuk Lymphoma. 2009;50: 1589-1596.
    • (2009) Leuk Lymphoma , vol.50 , pp. 1589-1596
    • Byrd, J.C.1    Peterson, B.L.2    Rai, K.R.3
  • 41
    • 51249108295 scopus 로고    scopus 로고
    • Consolidation therapy with subcutaneous alemtuzumab results in severe infectious toxicity in previously untreated CLL patients who achieve a complete response after fludarabine and rituximab induction therapy: Interim safety analysis of the CALGB Study 10101
    • ASH Annual Meeting Abstracts, Abstract 755
    • Lin TS, Donohue KA, Lucas MS, et al. Consolidation therapy with subcutaneous alemtuzumab results in severe infectious toxicity in previously untreated CLL patients who achieve a complete response after fludarabine and rituximab induction therapy: interim safety analysis of the CALGB Study 10101. Blood (ASH Annual Meeting Abstracts). 2007;110:Abstract 755.
    • (2007) Blood , pp. 110
    • Lin, T.S.1    Donohue, K.A.2    Lucas, M.S.3
  • 42
    • 77950311326 scopus 로고    scopus 로고
    • Consolidation therapy with subcutaneous (SC) alemtuzumab after fludarabine and rituximab (FR) induction therapy improves the complete response (CR) rate in chronic lymphocytic leukemia (CLL) and eradicates minimal residual disease (MRD) but is associated with severe infectious toxicity: Final analysis of CALGB study 10101
    • ASH Annual Meeting Abstracts, Abstract 210
    • Lin TS, Donohue KA, Byrd JC, et al. Consolidation therapy with subcutaneous (SC) alemtuzumab after fludarabine and rituximab (FR) induction therapy improves the complete response (CR) rate in chronic lymphocytic leukemia (CLL) and eradicates minimal residual disease (MRD) but is associated with severe infectious toxicity: final analysis of CALGB study 10101. Blood (ASH Annual Meeting Abstracts). 2009;114:Abstract 210.
    • (2009) Blood , pp. 114
    • Lin, T.S.1    Donohue, K.A.2    Byrd, J.C.3
  • 43
    • 34548028700 scopus 로고    scopus 로고
    • Population pharmacokineticspharmacodynamics of alemtuzumab (Campath) in patients with chronic lymphocytic leukaemia and its link to treatment response
    • Mould DR, Baumann A, Kuhlmann J, et al. Population pharmacokineticspharmacodynamics of alemtuzumab (Campath) in patients with chronic lymphocytic leukaemia and its link to treatment response. Br J Clin Pharmacol. 2007;64:278-291.
    • (2007) Br J Clin Pharmacol , vol.64 , pp. 278-291
    • Mould, D.R.1    Baumann, A.2    Kuhlmann, J.3
  • 44
    • 3843129540 scopus 로고    scopus 로고
    • Blood concentrations of alemtuzumab and antiglobulin responses in patients with chronic lymphocytic leukemia following intravenous or subcutaneous routes of administration
    • Hale G, Rebello P, Brettman LR, et al. Blood concentrations of alemtuzumab and antiglobulin responses in patients with chronic lymphocytic leukemia following intravenous or subcutaneous routes of administration. Blood. 2004;104: 948-955.
    • (2004) Blood , vol.104 , pp. 948-955
    • Hale, G.1    Rebello, P.2    Brettman, L.R.3
  • 45
    • 33750199616 scopus 로고    scopus 로고
    • Updated guidelines on the management of cytomegalovirus reactivation in patients with chronic lymphocytic leukemia treated with alemtuzumab
    • O'Brien SM, Keating MJ, Mocarski ES. Updated guidelines on the management of cytomegalovirus reactivation in patients with chronic lymphocytic leukemia treated with alemtuzumab. Clin Lymphoma Myeloma. 2006;7:125-130.
    • (2006) Clin Lymphoma Myeloma , vol.7 , pp. 125-130
    • O'Brien, S.M.1    Keating, M.J.2    Mocarski, E.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.