Avastin in the treatment for radiation necrosis: Exciting results from a recent randomized trial

World Neurosurgery

Volumn 75, Issue 1, 2011, Pages 4-5

  Rahman, Maryam ^a   Hoh, Brian L ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; CORTICOSTEROID; DEXAMETHASONE; IRINOTECAN; TEMOZOLOMIDE; MONOCLONAL ANTIBODY;

BRAIN METASTASIS; CANCER RADIOTHERAPY; CORTICOSTEROID THERAPY; GLIOBLASTOMA; HEAD AND NECK CARCINOMA; HUMAN; HYPOXIA; LUNG EMBOLISM; RADIATION NECROSIS; SAGITTAL SINUS THROMBOSIS; SHORT SURVEY; UNSPECIFIED SIDE EFFECT; BRAIN TUMOR; NECROSIS; NOTE; PATHOLOGY; RADIATION INJURY; RANDOMIZED CONTROLLED TRIAL (TOPIC); TREATMENT OUTCOME;

ANTIBODIES, MONOCLONAL; BRAIN NEOPLASMS; HUMANS; NECROSIS; RADIATION INJURIES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 79959818893     PISSN: 18788750     EISSN: 18788769     Source Type: Journal    
DOI: 10.1016/j.wneu.2011.01.012     Document Type: Short Survey

References (19)

1. Brandes AA, Franceschi E, Tosoni A, Blatt V, Pession A, Tallini G, Bertorelle R, Bartolini S, Calbucci F, Andreoli A, Frezza G, Leonardi M, Spagnolli F, Ermani M: MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients. J Clin Oncol 26:2192-2197, 2008.
2. Brandsma D, Stalpers L, Taal W, Sminia P, Van Den Bent MJ: Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas. Lancet Oncol 9:453-461, 2008. (Pubitemid 351597795)
3. Chamberlain MC, Glantz MJ, Chalmers L, Van Horn A, Sloan AE: Early necrosis following concurrent Temodar and radiotherapyinpatients with glioblastoma. J Neurooncol 82:81-83, 2007.
4. Chaskis C, Neyns B, Michotte A, De Ridder M, Everaert H: Pseudoprogression after radiotherapy with concurrent temozolomide for high-grade glioma: clinical observations and working recommendations. Surg Neurol 72:423-428, 2009.
5. Covarrubias DJ, Rosen BR, Lev MH: Dynamic magnetic resonance perfusion imaging of brain tumors. Oncologist 9:528-537, 2004. (Pubitemid 39332316)
6. De Wit MC, De Bruin HG, Eijkenboom W, Sillevis Smitt PA, Van Den Bent MJ: Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression. Neurology 63:535-537, 2004. (Pubitemid 39031388)
7. Furuse M, Kawabata S, Kuroiwa T, Miyatake SI: Repeated treatments with bevacizumab for recurrent radiation necrosis in patients with malignant brain tumors: a report of 2 cases. J Neurooncol In press.
8. Giglio P, Gilbert MR: Cerebral radiation necrosis. Neurologist 9:180-188, 2003. (Pubitemid 36944725)
9. Gonzalez J, Kumar AJ, Conrad CA, Levin VA: Effect of bevacizumab on radiation necrosis of the brain. Int J Radiat Oncol Biol Phys 67:323-326, 2007. (Pubitemid 46108339)
10. Hegi ME, Diserens AC, Gorlia T, Hamou MF, De Tribolet N, Weller M, Kros JM, Hainfellner JA, Mason W, Mariani L, Bromberg JE, Hau P, Mirimanoff RO, Cairncross JG, Janzer R C, Stupp R: MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352:997-1003, 2005. (Pubitemid 40349502)
11. Kim JH, Chung YG, Kim CY, Kim HK, Lee HK: Upregulation of VEGF and FGF2 in normal rat brain after experimental intraoperative radiation therapy. J Korean Med Sci 19:879-886, 2004. (Pubitemid 40104884)
12. Kumar AJ, Leeds NE, Fuller GN, Van Tassel P, Maor MH, Sawaya RE, Levin VA: Malignant gliomas: MR imaging spectrum of radiation therapy-and chemotherapy-induced necrosis of the brain after treatment. Radiology 217:377-384, 2000.
13. Levin VA, Bidaut L, Hou P, Kumar AJ, Wefel JS, Bekele BN, Prabhu S, Loghin M, Gilbert MR, Jackson EF: Randomized double-blind placebo-controlled trial of bevacizumab therapy for radiation necrosis of the central nervous system. Int J Radiat Oncol Biol Phys In press.
14. Li YQ, Ballinger JR, Nordal RA, Su ZF, Wong CS: Hypoxia in radiation-induced blood-spinal cord barrier breakdown. Cancer Res 61:3348-3354, 2001. (Pubitemid 32695024)
15. Nordal RA, Nagy A, Pintilie M, Wong CS: Hypoxia and hypoxia-inducible factor-1 target genes in central nervous system radiation injury: a role for vascular endothelial growth factor. Clin Cancer Res 10:3342-3353, 2004. (Pubitemid 38685439)
16. Stupp R, Hegi ME, Mason WP, Van Den Bent MJ, Taphoorn MJ, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, Hau P, Brandes AA, Gijtenbeek J, Marosi C, Vecht CJ, Mokhtari K, Wesseling P, Villa S, Eisenhauer E, Gorlia T, Weller M, Lacombe D, Cairncross JG, Mirimanoff RO; European Organisation for Research and Treatment of Cancer Brain Tumour and Radiation Oncology Groups; National Cancer Institute of Canada Clinical Trials Group: Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysisofthe EORTC-NCIC trial. Lancet Oncol 10:459-466, 2009.
17. Stupp R, Mason WP, Van Den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO; European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987-996, 2005.
18. Torcuator R, Zuniga R, Mohan YS, Rock J, Doyle T, Anderson J, Gutierrez J, Ryu S, Jain R, Rosenblum M, Mikkelsen T: Initial experience with bevacizumab treatment for biopsy confirmed cerebral radiation necrosis. J Neurooncol 94:63-68, 2009.
19. Wong CS, Van Der Kogel AJ: Mechanisms of radiation injury to the central nervous system: implications for neuroprotection. Mol Interv 4:273-284, 2004.