Neoadjuvant chemoradiation for clinically advanced non-small cell lung cancer: An analysis of 233 patients

Annals of Thoracic Surgery

Volumn 92, Issue 1, 2011, Pages 233-243

  Kim, Anthony W ^a   Liptay, Michael J ^b   Bonomi, Philip ^b   Warren, William H ^b   Basu, Sanjib ^b   Farlow, Erin C ^b   Faber, L Penfield ^b,c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

^c University Surgeons   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; CISPLATIN; ETOPOSIDE; FLUOROURACIL; PACLITAXEL;

ADJUVANT CHEMOTHERAPY; ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ADVANCED CANCER; AGED; ARTICLE; BRONCHOPLEURAL FISTULA; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; ESOPHAGUS PERFORATION; FEMALE; HEART ARRHYTHMIA; HEMOPTYSIS; HUMAN; LUNG LOBECTOMY; LUNG NON SMALL CELL CANCER; LUNG RESECTION; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MULTIPLE CYCLE TREATMENT; OVERALL SURVIVAL; PRIORITY JOURNAL; RESPIRATORY FAILURE; RETROSPECTIVE STUDY; THROMBOEMBOLISM;

ADULT; AGED; ANALYSIS OF VARIANCE; CARCINOMA, NON-SMALL-CELL LUNG; CHEMOTHERAPY, ADJUVANT; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; KAPLAN-MEIER ESTIMATE; LUNG NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOADJUVANT THERAPY; NEOPLASM STAGING; PNEUMONECTOMY; POSTOPERATIVE COMPLICATIONS; PROPORTIONAL HAZARDS MODELS; RADIOTHERAPY, ADJUVANT; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 79959790394     PISSN: 00034975     EISSN: 15526259     Source Type: Journal    
DOI: 10.1016/j.athoracsur.2011.03.001     Document Type: Article

References (28)

1. L.P. Faber, C.F. Kittle, and W.H. Warren Preoperative chemotherapy and irradiation for stage III non-small cell lung cancer Ann Thorac Surg 47 1989 669 675 discussion 6767
2. R.T. Eagan, C. Ruud, R.E. Lee, P.C. Pairolero, and M.H. Gail Pilot study of induction therapy with cyclophosphamide, doxorubicin, and cisplatin (CAP) and chest irradiation prior to thoracotomy in initially inoperable stage III M0 non-small cell lung cancer Cancer Treat Rep 71 1987 895 900
3. A. Skarin, M. Jochelson, and T. Sheldon Neoadjuvant chemotherapy in marginally resectable stage III M0 non-small cell lung cancer: long-term follow-up in 41 patients J Surg Oncol 40 1989 266 274
4. A.W. Kim, L.P. Faber, and W.H. Warren Pneumonectomy after chemoradiation therapy for non-small cell lung cancer: does "side" really matter? Ann Thorac Surg 88 2009 937 943 discussion 944
5. Z. Mansour, E.A. Kochetkova, and N. Santelmo Persistent N2 disease after induction therapy does not jeopardize early and medium term outcomes of pneumonectomy Ann Thorac Surg 86 2008 228 233
6. P. Bonomi, Rowland, and S.G. Taylor Phase II trial of etoposide, cisplatin, continuous infusion 5-fluorouracil, and simultaneous split-course radiation therapy in stage III non-small-cell bronchogenic carcinoma K.% Semin Oncol 13 1986 115 120
7. D. Recine, K. Rowland, and S. Reddy Combined modality therapy for locally advanced non-small cell lung carcinoma Cancer 66 1990 2270 2278
8. S. Reddy, L.P. Faber, and L.A. Baumann Preoperative radiation therapy in regionally localized stage III non-small cell lung carcinoma: long-term results and patterns of failure Int J Radiat Oncol Biol Phys 19 1990 287 292
9. M.A. Taylor, S. Reddy, and M.S. Lee Combined modality treatment using BID radiation for locally advanced non-small cell lung carcinoma Cancer 73 1994 2599 2606
10. M.J. Edelman, M. Suntharalingam, and W. Burrows Phase I/II trial of hyperfractionated radiation and chemotherapy followed by surgery in stage III lung cancer Ann Thorac Surg 86 2008 903 910
11. M.J. Krasna, Z. Gamliel, and W.M. Burrows Pneumonectomy for lung cancer after preoperative concurrent chemotherapy and high-dose radiation Ann Thorac Surg 89 2010 200 206 discussion 206
12. M. Suntharalingam, R. Paulus, and M.J. Edelman RTOG 0229: A phase II trial of neoadjuvant therapy with concurrent chemotherapy and high-dose radiotherapy (XRT) followed by resection and consolidative therapy for LA-NSCLC J Clin Oncol 28 2010 15S (Abstract 7024)
13. R. Bueno, W.G. Richards, and S.J. Swanson Nodal stage after induction therapy for stage IIIA lung cancer determines patient survival Ann Thorac Surg 70 2000 1826 1831
14. J.L. Port, R.J. Korst, and P.C. Lee Surgical resection for residual N2 disease after induction chemotherapy Ann Thorac Surg 79 2005 1686 1690
15. N. Lorent, P. DeLeyn, and Y. Lievens Long-term survival of surgically staged IIIA-N2 non-small-cell lung cancer treated with surgical combined modality approach: analysis of a 7-year prospective experience Ann Oncol 15 2004 1645 1653
16. C. Dooms, E. Verbeken, and S. Stroobants Prognostic stratification of stage IIIA-N2 non-small-cell lung cancer after induction chemotherapy: a model based on the combination of morphometric-pathologic response in mediastinal nodes and primary tumor response on serial 18-fluoro-2-deoxy-glucose positron emission tomography J Clin Oncol 26 2008 1128 1134
17. R.J. Cerfolio, L. Maniscalco, and A.S. Bryant The treatment of patients with stage IIIA non-small cell lung cancer from N2 disease: who returns to the surgical arena and who survives Ann Thorac Surg 86 2008 912 920 discussion 91220
18. R.J. Cerfolio, A.S. Bryant, V.L. Jones, and R.M. Cerfolio Pulmonary resection after concurrent chemotherapy and high dose (60Gy) radiation for non-small cell lung cancer is safe and may provide increased survival Eur J Cardiothorac Surg 35 2009 718 723 discussion 723
19. J. Deslauriers, J. Gregoire, and L.F. Jacques Sleeve lobectomy versus pneumonectomy for lung cancer: a comparative analysis of survival and sites or recurrences Ann Thorac Surg 77 2004 1152 1156 discussion 1156
20. J.E. Bauman, M.S. Mulligan, and R.G. Martins Salvage lung resection after definitive radiation (>59 Gy) for non-small cell lung cancer: surgical and oncologic outcomes Ann Thorac Surg 86 2008 1632 1638 discussion 16389
21. S. Takeda, H. Maeda, and T. Okada Results of pulmonary resection following neoadjuvant therapy for locally advanced (IIIA-IIIB) lung cancer Eur J Cardiothorac Surg 30 2006 184 189
22. A. Carretta, P. Ciriaco, and G. Melloni Results of surgical treatment after neoadjuvant chemotherapy for stage III non-small cell lung cancer World J Surg 32 2008 2636 2642
23. M.T. Jaklitsch, J.E. Herndon 2nd, and M.M. DeCamp Jr Nodal downstaging predicts survival following induction chemotherapy for stage IIIA (N2) non-small cell lung cancer in CALGB protocol #8935 J Surg Oncol 94 2006 599 606
24. G.A. Silvestri, M.K. Gould, and M.L. Margolis Noninvasive staging of non-small cell lung cancer: ACCP evidenced-based clinical practice guidelines (2nd edition) Chest 132 2007 178 201S
25. R.J. Cerfolio, and A.S. Bryant Survival of patients with unsuspected N2 (stage IIIA) nonsmall-cell lung cancer Ann Thorac Surg 86 2008 362 366 discussion 3667
26. M. Inoue, N. Sawabata, and S. Takeda Results of surgical intervention for p-stage IIIA (N2) non-small cell lung cancer: acceptable prognosis predicted by complete resection in patients with single N2 disease with primary tumor in the upper lobe J Thorac Cardiovasc Surg 127 2004 1100 1106
27. P. Misthos, E. Sepsas, J. Kokotsakis, I. Skottis, and A. Lioulias The significance of one-station N2 disease in the prognosis of patients with nonsmall-cell lung cancer Ann Thorac Surg 86 2008 1626 1630
28. F. Tanaka, K. Yanagihara, and Y. Otake Prognostic factors in resected pathologic (p-) stage IIIA-N2, non-small-cell lung cancer Ann Surg Oncol 11 2004 612 618