Combined structural and functional investigation of a C-3′′- ketoreductase involved in the biosynthesis of dTDP-l-digitoxose

Biochemistry

Volumn 50, Issue 26, 2011, Pages 5905-5917

  Kubiak, Rachel L ^a   Holden, Hazel M ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ANTITUMOR ANTIBIOTICS; CATALYTIC ROLE; CONFORMATIONAL CHANGE; GLUCOSE 1-PHOSPHATE; HIGH-RESOLUTION STRUCTURES; KETO GROUPS; LYSINE MUTATION; MUTANT PROTEINS; NATURAL PRODUCTS; OXIDOREDUCTASES; SOIL-DWELLING; TERNARY COMPLEX; WILD-TYPE ENZYMES;

AMIDES; AMINO ACIDS; ANTIBIOTICS; BIOCHEMISTRY; BIOSYNTHESIS; ENZYMES; FRUCTOSE; GLUCOSE; INVESTMENTS; PROTEINS;

CATALYST ACTIVITY;

DIGITOXOSE; KIJD10 PROTEIN; LYSINE; NICOTINAMIDE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TYROSINE; UNCLASSIFIED DRUG;

ACTINOMADURA KIJANIATA; ARTICLE; BACTERIUM; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; PRIORITY JOURNAL; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; WILD TYPE;

ACTINOMYCETALES; ALCOHOL OXIDOREDUCTASES; BENZENE; BINDING SITES; HEXOSES; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; NADP; NUCLEOSIDE DIPHOSPHATE SUGARS; PROTEIN CONFORMATION;

ACTINOMADURA KIJANIATA; BACTERIA (MICROORGANISMS);

EID: 79959782300     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200514b     Document Type: Article

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