Structures of dimeric dihydrodiol dehydrogenase apoenzyme and inhibitor complex: Probing the subunit interface with site-directed mutagenesis

Proteins: Structure, Function and Genetics

Volumn 70, Issue 1, 2008, Pages 176-187

  Carbone, Vincenzo ^a   Endo, Satoshi ^b   Sumii, Rie ^b   Chung, Roland P T ^a   Matsunaga, Toshiyuki ^b   Hara, Akira ^b   El Kabbani, Ossama ^a  

^a MONASH UNIVERSITY   (Australia)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Dimeric dihydrodiol dehydrogenase; Inhibitor complex; Inter subunit interaction; Site directed mutagenesis; X ray crystallography

Indexed keywords

4 HYDROXYACETOPHENONE; APOENZYME; AROMATIC HYDROCARBON; ASPARTIC ACID; CATECHOL; DIHYDRODIOL DEHYDROGENASE; DIMER; DINUCLEOTIDE; GLUCOSE FRUCTOSE OXIDOREDUCTASE; GLYCEROL; LEUCINE; LYSINE; MONOMER; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OLIGOMER; OXIDOREDUCTASE; PHENYLALANINE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITOR COMPLEX; HYDROGEN BOND; OXIDATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA, COMPLEMENTARY; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR PROBES; MUTAGENESIS, SITE-DIRECTED; OXIDOREDUCTASES; PROTEIN STRUCTURE, SECONDARY;

MAMMALIA; PROKARYOTA; ZYMOMONAS MOBILIS;

EID: 37448999171     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21566     Document Type: Article

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