Carbon black nanoparticles impair acetylation of aromatic amine carcinogens through inactivation of arylamine N -acetyltransferase enzymes

ACS Nano

Volumn 5, Issue 6, 2011, Pages 4504-4511

  Sanfins, Elodie ^a   Dairou, Julien ^a   Hussain, Salik ^a   Busi, Florent ^a   Chaffotte, Alain F ^b   Rodrigues Lima, Fernando ^a   Dupret, Jean Marie ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b INSTITUT PASTEUR   (France)

Author keywords

enzyme; irreversible inhibition; lung Clara cells; protein conformation; xenobiotic metabolism

Indexed keywords

ACETYL TRANSFERASE; AROMATIC AMINES; ARYL AMINES; ARYLAMINE N-ACETYLTRANSFERASES; BIOPHYSICAL ANALYSIS; CONFORMATIONAL CHANGE; HUMAN CARCINOGEN; IRREVERSIBLE INHIBITIONS; IRREVERSIBLE LOSS; LUNG CLARA CELLS; PROTEIN CONFORMATION; TOXICOLOGICAL EFFECTS; XENOBIOTIC METABOLISM;

AMINES; AROMATIC COMPOUNDS; BIOLOGICAL ORGANS; CARBON BLACK; CARCINOGENS; CATALYSTS; DETOXIFICATION; ENZYME ACTIVITY; NANOPARTICLES;

ACETYLATION;

CARCINOGEN; METAL NANOPARTICLE; NANOPARTICLE; REACTIVE OXYGEN METABOLITE; RECOMBINANT PROTEIN; XENOBIOTIC AGENT;

ACETYLATION; ARTICLE; BIOPHYSICS; CHEMISTRY; CYTOLOGY; ESCHERICHIA COLI; HUMAN; KINETICS; LUNG; METABOLISM; METHODOLOGY; NANOTECHNOLOGY; PLASMID; PROTEIN CONFORMATION; SOOT;

ACETYLATION; BIOPHYSICS; CARCINOGENS; ESCHERICHIA COLI; HUMANS; KINETICS; LUNG; METAL NANOPARTICLES; NANOPARTICLES; NANOTECHNOLOGY; PLASMIDS; PROTEIN CONFORMATION; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; SOOT; XENOBIOTICS;

EID: 79959780091     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn103534d     Document Type: Article

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