HOXC11-SRC-1 regulation of S100beta in cutaneous melanoma: New targets for the kinase inhibitor dasatinib

British Journal of Cancer

Volumn 105, Issue 1, 2011, Pages 118-123

  Deblacam, C ^a   Byrne, C ^a   Hughes, E ^a   McIlroy, M ^a   Bane, F ^a   Hill, A D K ^a   Young, L S ^a  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

Author keywords

dasatinib; HOXC11; melanoma; S100beta; SRC 1

Indexed keywords

BIOLOGICAL MARKER; DASATINIB; MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HOXC 11; TRANSCRIPTION FACTOR SRC 1; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DISEASE COURSE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MELANOMA; MELANOMA CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INTERACTION; REGULATORY MECHANISM; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOPRECIPITATION; MELANOMA; NERVE GROWTH FACTORS; NUCLEAR RECEPTOR COACTIVATOR 1; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; PYRIMIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; S100 PROTEINS; SKIN NEOPLASMS; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 79959767761     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2011.193     Document Type: Article

References (21)

1. Allore RJ, Friend WC, O'Hanlon D, Neilson KM, Baumal R, Dunn RJ, Marks A (1990) Cloning and expression of the human S100 beta gene. J Biol Chem 265: 15537-15543
2. Donato R, Sorci G, Riuzzi F, Arcuri C, Bianchi R, Brozzi F, Tubaro C, Giambanco I (2009) S100B's double life: intracellular regulator and extracellular signal. Biochim Biophys Acta 3: 1008-1022
3. Gregory CW, He B, Johnson Jr RT, Ford OH, Mohler JL, French FS, Wilson EM (2001) A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy. Cancer Res 61: 4315-4319 (Pubitemid 32685750)
4. Jiang H, Shah S, Hilt DC (1993) Organization, sequence, and expression of the murine S100 beta gene. Transcriptional regulation by cell type-specific cis-acting regulatory elements. J Biol Chem 268: 20502-20511 (Pubitemid 23278962)
5. Kavanagh DO, McIlroy M, Myers E, Bane F, Crotty TB, McDermott E, Hill AD, Young LS (2010) The role of oestrogen receptor {alpha} in human thyroid cancer: contributions from coregulatory proteins and the tyrosine kinase receptor HER2. Endocr Relat Cancer 17: 255-264
6. Kluger HM, Dudek AZ, McCann C, Ritacco J, Southard N, Jilaveanu LB (2010) A Phase 2 trial of Dasatinib in advanced melanoma. Cancer 117: 2202-2208
7. Maeda K, Hamada J, Takahashi Y, Tada M, Yamamoto Y, Sugihara T, Moriuchi T (2005) Altered expressions of HOX genes in human cutaneous malignant melanoma. Int J Cancer 114: 436-441 (Pubitemid 40279966)
8. McIlroy M, McCartan D, Early S, O Gaora P, Pennington S, Hill AD, Young LS (2010) Interaction of developmental transcription factor HOXC11 with steroid receptor coactivator SRC-1 mediates resistance to endocrine therapy in breast cancer. Cancer Res 70: 1585-1594
9. Mocellin S, Zavagno G, Nitti D (2008) The prognostic value of serum S100beta in patients with cutaneous melanoma: a meta-analysis. Int J Cancer 123: 2370-2376
10. Modi PK, Kanungo MS (2010) Age-dependent expression of S100b in the brain of mice. Cell Mol Neurobiol 30: 709-716
11. Redmond AM, Bane FT, Stafford AT, McIlroy M, Dillon MF, Crotty TB, Hill AD, Young LS (2009) Coassociation of estrogen receptor and p160 proteins predicts resistance to endocrine treatment; SRC-1 is an independent predictor of breast cancer recurrence. Clin Cancer Res 15: 2098-2106
12. Riker AI, Enkemann SA, Fodstad O, Liu S, Ren S, Morris C, Xi Y, Howell P, Metge B, Samant RS, Shevde LA, Li W, Eschrich S, Daud A, Ju J, Matta J (2008) The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis. BMC Med Genomics 1: 13
13. Samuel S, Naora H (2005) Homeobox gene expression in cancer: insights from developmental regulation and deregulation. Eur J Cancer 41: 2428-2437 (Pubitemid 41540620)
14. Shah N, Sukumar S (2010) The Hox genes and their roles in oncogenesis. Nat Rev Cancer 10: 361-371
15. Shah YM, Rowan BG (2005) The Src kinase pathway promotes tamoxifen agonist action in Ishikawa endometrial cells through phosphorylation-dependent stabilization of estrogen receptor (alpha) promoter interaction and elevated steroid receptor coactivator 1 activity. Mol Endocrinol 19: 732-748 (Pubitemid 40349444)
16. Shang Y, Brown M (2002) Molecular determinants for the tissue specificity of SERMs. Science 295: 2465-2468 (Pubitemid 34270263)
17. Talpaz M, Shah NP, Kantarjian H, Donato N, Nicoll J, Paquette R, Cortes J, O'Brien S, Nicaise C, Bleickardt E, Blackwood-Chirchir MA, Iyer V, Chen TT, Huang F, Decillis AP, Sawyers CL (2006) Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 354(24): 2531-2541 (Pubitemid 43882349)
18. Vallabhaneni S, Nair BC, Cortez V, Challa R, Chakravarty D, Tekmal RR, Vadlamudi RK (2010) Significance of ER-Src axis in hormonal therapy resistance. Breast Cancer Res Treat; e-pub ahead of print
19. Wang S, Yuan Y, Liao L, Kuang SQ, Tien JC, O'Malley BW, Xu J (2009) Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation. Proc Natl Acad Sci USA 106: 151-156
20. Zhang X, Hamada J, Nishimoto A, Takahashi Y, Murai T, Tada M, Moriuchi T (2007) HOXC6 and HOXC11 increase transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwannian cells. J Cell Mol Med 11: 299-306 (Pubitemid 46693328)
21. Zimmer DB, Cornwall EH, Landar A, Song W (1995) The S100 protein family: history, function, and expression. Brain Res Bull 37: 417-429