Psychotropic drug use in community-dwelling elderly people - Characteristics of persistent and incident users

European Journal of Clinical Pharmacology

Volumn 67, Issue 7, 2011, Pages 731-739

  Rikala, Maria ^a   Korhonen, Maarit Jaana ^b   Sulkava, Raimo ^a,c   Hartikainen, Sirpa ^a,d  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

^d Leppavirta Health Centre   (Finland)

Author keywords

Elderly; Incidence; Persistent use; Psychotropic drugs

Indexed keywords

ANTIDEPRESSANT AGENT; BENZODIAZEPINE DERIVATIVE; NEUROLEPTIC AGENT;

AGED; AGING; ARTICLE; COGNITION; COHORT ANALYSIS; COMMUNITY; CONTROLLED STUDY; DEPRESSION; DRUG USE; FEMALE; FOLLOW UP; FUNCTIONAL STATUS; HEALTH STATUS; HUMAN; LIFE SATISFACTION; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PRIORITY JOURNAL; PROSPECTIVE PRICING; RANDOMIZED CONTROLLED TRIAL; SELF EVALUATION;

AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; COHORT STUDIES; DRUG PRESCRIPTIONS; DRUG UTILIZATION; FEMALE; GERIATRIC ASSESSMENT; HEALTH SERVICES FOR THE AGED; HUMANS; MALE; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; PSYCHOTROPIC DRUGS; QUESTIONNAIRES; RISK FACTORS; SUBSTANCE-RELATED DISORDERS;

EID: 79959765562     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-011-0996-5     Document Type: Article

References (43)

1. Aparasu RR, Mort JR, Brandt H (2003) Psychotropic prescription use by community-dwelling elderly in the United States. J Am Geriatr Soc 51:671-677 (Pubitemid 36541432)
2. Hartikainen S, Rahkonen T, Kautiainen H, Sulkava R (2003) Use of psychotropics among home-dwelling nondemented and demented elderly. Int J Geriatr Psychiatry 18:1135-1141 (Pubitemid 38049247)
3. Guthrie B, Clark SA, McCowan C (2010) The burden of psychotropic drug prescribing in people with dementia: a population database study. Age Ageing 39:637-642
4. Hartikainen S, Lönnroos E, Louhivuori K (2007) Medication as a risk factor for falls: critical systematic review. J Gerontol A Biol Sci Med Sci 62:1172-1181 (Pubitemid 47599431)
5. Woolcott JC, Richardson KJ, Wiens MO et al (2009) Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med 169:1952-1960
6. Ashton H (2005) The diagnosis and management of benzodiazepine dependence. Curr Opin Psychiatry 18:249-255
7. Glass J, Lanctôt KL, Herrmann N, Sproule BA, Busto UE (2005) Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits. Br Med J 19(331):1169
8. Gill SS, Bronskill SE, Normand SL et al (2007) Antipsychotic Drug Use and Mortality in Older Adults with Dementia. Ann Intern Med 146:775-786 (Pubitemid 351650498)
9. Ballard C, Hanney ML, Theodoulou M et al (2009) The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomised placebo-controlled trial. Lancet Neurol 8:151-157
10. Alexopoulos GS, Katz IR, Reynolds CF 3rd, Carpenter D, Docherty JP, Ross RW (2001) Pharmacotherapy of depression in older patients: A summary of the expert consensus guidelines. J Psychiatr Pract 7:361-376
11. American Psychiatric Association (2007) Practice guideline for the treatment of patients with Alzheimer's disease and other dementias. 2nd edn. Available at: http://www.psychiatryonline.com/pracGuide/PracticePDFs/ AlzPG101007.pdf. Accessed 4 Jan 2011
12. Alexopoulos GS, Streim J, Carpenter D, Docherty JP (2004) Expert Consensus Panel for Using Antipsychotic Drugs in Older Patients Using antipsychotic drugs in older patients. J Clin Psychiatry 65[Suppl 2]:5-99
13. Simon GE, VonKorff M, Barlow W, Pabiniak C, Wagner E (1996) Predictors of chronic benzodiazepine use in a health maintenance organization sample. J Clin Epidemiol 49:1067-1073 (Pubitemid 26319043)
14. Isacson D (1997) Long-term benzodiazepine use: factors of importance and the development of individual use patterns over time - a 13-year follow-up in a Swedish community. Soc Sci Med 44:1871-1880
15. Fang SY, Chen CY, Chang IS, Wu EC, Chang CM, Lin KM (2009) Predictors of the incidence and discontinuation of longterm use of benzodiazepines: a population-based study. Drug Alcohol Depend 104:140-146
16. Cunningham CM, Hanley GE, Morgan S (2010) Patterns in the use of benzodiazepines in British Columbia: examining the impact of increasing research and guideline cautions against long-term use. Health Policy 97:122-129
17. Dealberto MJ, Seeman T, McAvay GJ, Berkman L (1997) Factors related to current and subsequent psychotropic drug use in an elderly cohort. J Clin Epidemiol 50:357-364 (Pubitemid 27165714)
18. Egan M, Moride Y, Wolfson C, Monette J (2000) Long-term continuous use of benzodiazepines by older adults in Quebec: prevalence, incidence, and risk factors. J Am Geriatr Soc 48:811-816 (Pubitemid 30457421)
19. Jorm AF, Grayson D, Creasey H, Waite L, Broe GA (2000) Longterm benzodiazepine use by elderly people living in the community. Aust N Z J Public Health 24:7-10 (Pubitemid 30113593)
20. Fourrier A, Letenneur L, Dartiques JF, Moore N, Bégaud B (2001) Benzodiazepine use in an elderly community-dwelling population. Characteristics of users and factors associated with subsequent use. Eur J Clin Pharmacol 57:419-425 (Pubitemid 33787193)
21. Gray SL, Eggen AE, Blough D, Buchner D, LaCroix AZ (2003) Benzodiazepine use in older adults enrolled in a health maintenance organization. Am J Geriatr Psychiatry 11:568-576 (Pubitemid 37093384)
22. Fortin D, Préville M, Ducharme C et al (2007) Factors associated with long-term benzodiazepine use among elderly women and men in Quebec. J Women Aging 19:37-52
23. Alvarenga JM, Loyola Filho AI, Firmo JO, Lima-Costa MF, Uchoa E (2008) Prevalence and sociodemographic characteristics associated with benzodiazepines use among community dwelling older adults: the Bambuí Health and Aging Study (BHAS). Rev Bras Psiquiatr 30:7-11 (Pubitemid 351507992)
24. Soudry A, Dufouil C, Ratchie K, Dartiques JF, Tzourio C, Alpérovitch A (2008) Factors associated with changes in antidepressant use in a community-dwelling elderly cohort: the Three-City Study. Eur J Clin Pharmacol 64:51-59
25. Stowell KR, Chang CC, Bilt J, Stoehr GP, Ganguli M (2008) Sustained benzodiazepines use in a community sample of older adults. J Am Geriatr Soc 56:2285-2291
26. Luijendijk HJ, Tiemeier H, Hofman A, Heeringa J, Stricker BH (2008) Determinants of chronic benzodiazepine use in the elderly: a longitudinal study. Br J Clin Pharmacol 65:593-599 (Pubitemid 351365131)
27. Lechevallier-Michel N, Berr C, Fourrier-Réglat A (2005) Incidence and characteristics of benzodiazepine use in an elderly cohort: the EVA study. Therapie 60:561-566
28. Bartlett G, Abrahamowicz M, Grad R, Sylvestre MP, Tamplyn R (2009) Association between risk factors for injurious falls and new benzodiazepine prescribing in elderly persons. BMC Fam Pract 6(10):1
29. Rikala M, Korhonen MJ, Sulkava R, Hartikainen S (2010) The effects of medication assessment on psychotropic drug use in the community-dwelling elderly. Int Psychogeriatr 14:1-12 (Epub ahead of print)
30. Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198
31. Sheikh JI, Yesavage JA (1986) Geriatric depression scale (GDS): recent evidence and development of a shorter version. Clin Gerontol 5:165-173 (Pubitemid 17221439)
32. Lawton MP, Brody EM (1969) Assessment of older people: selfmaintaining and instrumental activities of daily living. Gerontologist 9:179-186
33. WHO Collaborating Centre for Drug Statistics Methodology (2009) Guidelines for ATC classification and DDD assignment 2010, Oslo. Available at: http://www.whocc.no/filearchive/publications/2010guidelines.pdf. Accessed 4 Jan 2011
34. McIntosh A, Cohen A, Turnbull N, et al (2004) Clinical guidelines and evidence review for panic disorder and generalised anxiety disorder. Sheffield: University of Sheffield/London: National Collaborating Centre for Primary Care. Available at: http://www.nice.org.uk/nicemedia/live/10960/29636/29636.pdf. Accessed 4 Jan 2011
35. American Psychiatric Association (2007) Practice guideline for the treatment of patients with obsessive-compulsive disorder. Arlington, VA: American Psychiatric Association. Available at: http://www.psychiatryonline.com/ pracGuide/loadGuidelinePdf.aspx?file=OCDPracticeGuidelineFinal05- 04-07 . Accessed 4 Jan 2011
36. Bartlett G, Abrahamowicz M, Tamblyn R, Grad R, Capek R, du Berger R (2004) Longitudinal patterns of new Benzodiazepine use in the elderly. Pharmacoepidemiol Drug Saf 13:669-682 (Pubitemid 39378276)
37. Saastamoinen L, Enlund H, Klaukka T (2008) Repeat prescribing in primary care: a prescription study. Pharm World Sci 30:605-609
38. Iliffe S, Curran HV, Collins R, Yuen Kee SC, Fletcher S, Woods B (2004) Attitudes to long-term use of benzodiazepine hypnotics by older people in general practice: findings from interviews with service users and providers. Aging Ment Health 8:242-248 (Pubitemid 38639439)
39. Cook JM, Biyanova T, Masci C, Coyne JC (2007) Older patient perspectives on long-term anxiolytic benzodiazepine use and discontinuation: A qualitative study. J Gen Intern Med 22:1094-1100 (Pubitemid 47038041)
40. Dickinson R, Knapp P, House AO et al (2010) Long-term prescribing of antidepressants in the older population: a qualitative study. Br J Gen Pract 60:144-155
41. Cook JM, Marshall R, Masci C, Coyne JC (2007) Physicians' perspectives on prescribing benzodiazepines for older adults: a qualitative study. J Gen Intern Med 22:303-307 (Pubitemid 46941221)
42. Rikala M, Hartikainen S, Sulkava R, Korhonen MJ (2010) Validity of the Finnish Prescription Register for measuring psychotropic drug exposures among elderly Finns: a population-based intervention study. Drugs Aging 27:337-349
43. Dekker FW, de Mutsert R, van Dijk PC, Zoccali C, Jager KJ (2008) Survival analysis: time-dependent effects and time-varying risk factors. Kidney Int 74:994-997