Reduced intraepidermal nerve fibre density in lesional and nonlesional prurigo nodularis skin as a potential sign of subclinical cutaneous neuropathy

British Journal of Dermatology

Volumn 165, Issue 1, 2011, Pages 85-91

  Schuhknecht, B ^a   Marziniak, M ^a   Wissel, A ^a   Phan, N Q ^a   Pappai, D ^a   Dangelmaier, J ^a   Metze, D ^a   Stander S ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PROTEIN GENE PRODUCT 9.5; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; EPIDERMIS; FEMALE; HUMAN; HUMAN TISSUE; HYPERKERATOSIS; HYPOPLASIA; IMMUNOHISTOCHEMISTRY; INTRAEPIDERMAL NERVE FIBRE DENSITY; MAJOR CLINICAL STUDY; MALE; NERVE FIBER; NEUROPATHY; NONMYELINATED NERVE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PRURIGO; PRURIGO NODULARIS; SKIN BIOPSY; SKIN DEFECT; SKIN NERVE; SKIN NODULE;

ADULT; AGED; AGED, 80 AND OVER; BIOPSY; COHORT STUDIES; EPIDERMIS; FEMALE; HUMANS; MALE; MIDDLE AGED; NERVE FIBERS; NEURAL CONDUCTION; OBSERVER VARIATION; PERIPHERAL NERVOUS SYSTEM DISEASES; PRURIGO;

EID: 79959747665     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2011.10306.x     Document Type: Article

References (49)

1. Accioly-Filho LW, Nogueira A, Ramos-de-Silva M,. Prurigo nodularis of Hyde: an update. J Eur Acad Dermatol Venereol 2000; 14: 75-82. (Pubitemid 32898943)
2. Vaidya DC, Schwartz RA,. Prurigo nodularis: a benign dermatosis derived from a persistent pruritus. Acta Dermatovenerol Croat 2008; 16: 38-44. (Pubitemid 351738201)
3. Lezcano L, Di Martino Ortiz B, Rodríguez Masi M, et al. Prurigo nodularis. Arch Argent Pediatr 2008; 106: 446-9.
4. Weigelt N, Metze D, Ständer S,. Prurigo nodularis: systematic analysis of 58 histological criteria in 136 patients. J Cutan Pathol 2010; 37: 578-86.
5. Lindley RP, Payne CM,. Neural hyperplasia is not a diagnostic prerequisite in nodular prurigo. A controlled morphometric microscopic study of 26 biopsy specimens. J Cutan Pathol 1989; 16: 14-18. (Pubitemid 19065872)
6. Rowland Payne CM, Wilkinson JD, McKee PH, et al. Nodular prurigo-a clinicopathological study of 46 patients. Br J Dermatol 1985; 113: 431-9. (Pubitemid 16217390)
7. Ikoma A, Steinhoff M, Ständer S, et al. The neurobiology of itch. Nat Rev Neurosci 2006; 7: 535-47. (Pubitemid 43995431)
8. Boulais N, Misery L,. The epidermis: a sensory tissue. Eur J Dermatol 2008; 18: 119-27. (Pubitemid 351554798)
9. Lauria G, Cornblath DR, Johansson O, et al. EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy. Eur J Neurol 2005; 12: 747-58. (Pubitemid 41495131)
10. Smith AG, Howard JR, Kroll R, et al. The reliability of skin biopsy with measurement of intraepidermal nerve fiber density. J Neurol Sci 2005; 228: 65-9. (Pubitemid 39656496)
11. Sommer F, Hensen P, Böckenholt B, et al. Underlying diseases and co-factors in patients with severe chronic pruritus: a 3-year retrospective study. Acta Derm Venereol (Stockh) 2007; 87: 510-16. (Pubitemid 351373395)
12. Hays AP,. Utility of skin biopsy to evaluate peripheral neuropathy. Curr Neurol Neurosci Rep 2010; 10: 101-7.
13. Wöpking S, Scherens A, Haussleiter IS, et al. Significant difference between three observers in the assessment of intraepidermal nerve fiber density in skin biopsy. BMC Neurol 2009; 31: 9-13.
14. Lauria G, Lombardi R, Camozzi F, et al. Skin biopsy for the diagnosis of peripheral neuropathy. Histopathology 2009; 54: 273-85.
15. England JD, Gronseth GS, Franklin G, et al. Practice parameter: the evaluation of distal symmetric polyneuropathy: the role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review). Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. PM R 2009; 1: 14-22.
16. Wang L, Hilliges M, Jernberg T, et al. Protein gene product 9.5-immunoreactive nerve fibres and cells in human skin. Cell Tissue Res 1990; 261: 25-33. (Pubitemid 20205948)
17. Hilliges M, Wang L, Johansson O,. Ultrastructural evidence for nerve fibers within all vital layers of the human epidermis. J Invest Dermatol 1995; 104: 134-7.
18. Johansson O, Wang L, Hilliges M, et al. Intraepidermal nerves in human skin: PGP 9.5 immunohistochemistry with special reference to the nerve density in skin from different body regions. J Peripher Nerv Syst 1999; 4: 43-52. (Pubitemid 29152256)
19. Zylka MJ, Rice FL, Anderson DJ,. Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron 2005; 45: 17-25. (Pubitemid 40075346)
20. Pautrier LM,. Le néurome de la lichénification circonscrite nodulaire chronique (lichen ruber obtusus corné prurigo nodularis). Ann Dermatol Syphiligr 1934; 7: 897-919.
21. Abadía Molina F, Burrows NP, Jones RR, et al. Increased sensory neuropeptides in nodular prurigo: a quantitative immunohistochemical analysis. Br J Dermatol 1992; 127: 344-51.
22. Cowan MA,. Neurohistological changes in prurigo nodularis. Arch Dermatol 1964; 89: 754-8.
23. Doyle JA, Connolly SM, Hunziker N, Winkelmann RK,. Prurigo nodularis: a reappraisal of the clinical and histologic features. J Cutan Pathol 1979; 6: 392-403. (Pubitemid 10248833)
24. Feuerman EJ, Sandbank M,. Prurigo nodularis. Histological and electron microscopical study. Arch Dermatol 1975; 111: 1472-7.
25. Harris B, Harris K, Penneys NS,. Demonstration by S-100 protein staining of increased numbers of nerves in the papillary dermis of patients with prurigo nodularis. J Am Acad Dermatol 1992; 26: 56-8.
26. Johansson O, Liang Y, Heilborn JD, et al. Langerhans cells in prurigo nodularis investigated by HLA-DR and S-100 immunofluorescence double staining. J Dermatol Sci 1998; 17: 24-32. (Pubitemid 28253043)
27. Johansson O, Liang Y, Marcusson JA, et al. Eosinophil cationic protein- and eosinophil-derived neurotoxin/eosinophil protein X-immunoreactive eosinophils in prurigo nodularis. Arch Dermatol Res 2000; 292: 371-8. (Pubitemid 30618102)
28. Johansson O, Liang Y, Emtestam L,. Increased nerve growth factor- and tyrosine kinase A-like immunoreactivities in prurigo nodularis skin-an exploration of the cause of neurohyperplasia. Arch Dermatol Res 2002; 293: 614-19. (Pubitemid 34209126)
29. Liang Y, Marcusson JA, Johansson O,. Light and electron microscopic immunohistochemical observations of p75 nerve growth factor receptor- immunoreactive dermal nerves in prurigo nodularis. Arch Dermatol Res 1999; 291: 14-21. (Pubitemid 29047922)
30. Liang Y, Jacobi HH, Reimert CM, et al. CGRP-immunoreactive nerves in prurigo nodularis-an exploration of neurogenic inflammation. J Cutan Pathol 2000; 27: 359-66. (Pubitemid 30427113)
31. Runne U, Orfanos CE,. Cutaneous neural proliferation in highly pruritic lesions of chronic prurigo. Arch Dermatol 1977; 113: 787-91. (Pubitemid 8131180)
32. Sandbank M,. Cutaneous nerve lesions in prurigo nodularis. Electron microscopic study of two patients. J Cutan Pathol 1976; 3: 125-32.
33. Vaalasti A, Suomalainen H, Rechardt L,. Calcitonin gene-related peptide immunoreactivity in prurigo nodularis: a comparative study with neurodermatitis circumscripta. Br J Dermatol 1989; 120: 619-23. (Pubitemid 19143292)
34. Liang Y, Heilborn JD, Marcusson JA, et al. Increased NGFr immunoreactive, dermal nerve fibers in prurigo nodularis. Eur J Dermatol 1996; 6: 563-7.
35. Liang Y, Marcusson JA, Jacobi HH, et al. Histamine-containing mast cells and their relationship to NGFr-immunoreactive nerves in prurigo nodularis: a reappraisal. J Cutan Pathol 1998; 25: 189-98. (Pubitemid 28188029)
36. Gøransson LG, Mellgren SI, Lindal S, et al. The effect of age and gender on epidermal nerve fiber density. Neurology 2004; 62: 774-7. (Pubitemid 38298955)
37. Bakkers M, Merkies IS, Lauria G, et al. Intraepidermal nerve fiber density and its application in sarcoidosis. Neurology 2009; 73: 1142-8.
38. Lauria G, Holland N, Hauer P, et al. Epidermal innervation: changes with aging, topographic location, and in sensory neuropathy. J Neurol Sci 1999; 164: 172-8. (Pubitemid 29288649)
39. Yamaoka J, Di ZH, Sun W, et al. Changes in cutaneous sensory nerve fibers induced by skin-scratching in mice. J Dermatol Sci 2007; 46: 41-51. (Pubitemid 46366632)
40. Kido M, Takeuchi S, Esaki H, et al. Scratching behavior does not necessarily correlate with epidermal nerve fiber sprouting or inflammatory cell infiltration. J Dermatol Sci 2010; 58: 130-5.
41. Lönndahl L, Lonne-Rahm SB, Nordlind K, et al. Decreased innervation of eczematous skin in NC/Nga atopic mice during chronic mild stress. Immunopharmacol Immunotoxicol 2010; 32: 147-52.
42. Devigili G, Tugnoli V, Penza P, et al. The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology. Brain 2008; 131: 1912-25. (Pubitemid 351957452)
43. Radtke C, Vogt PM, Devor M, et al. Keratinocytes acting on injured afferents induce extreme neuronal hyperexcitability and chronic pain. Pain 2010; 148: 94-102.
44. Tominaga M, Ogawa H, Takamori K,. Possible roles of epidermal opioid systems in pruritus of atopic dermatitis. J Invest Dermatol 2007; 127: 2228-35. (Pubitemid 47258501)
45. Bharati A, Wilson NJ,. Peripheral neuropathy associated with nodular prurigo. Clin Exp Dermatol 2007; 32: 67-70. (Pubitemid 46006372)
46. Batta K, Foulds IS, Colloby P,. Nodular prurigo occurring in the same distribution as sciatic pain from a prolapsed intervertebral disc. Br J Dermatol 1999; 141: 170-1. (Pubitemid 29333723)
47. Garcia-Moreno JM, Castilla JM, Garcia-Escudero A, Izquierdo G, Multifocal motor neuropathy with conduction blocks and prurigo nodularis. A paraneoplastic syndrome in a patient with non-Hodgkin B-cell lymphoma? Neurologia 2004; 19: 220-4. (Pubitemid 38715528)
48. Gencoglan G, Inanir I, Gunduz K,. Therapeutic hotline: treatment of prurigo nodularis and lichen simplex chronicus with gabapentin. Dermatol Ther 2010; 23: 194-8.
49. Dereli T, Karaca N, Inanir I, et al. Gabapentin for the treatment of recalcitrant chronic prurigo nodularis. Eur J Dermatol 2008; 18: 85-6. (Pubitemid 351158184)