Statistical adjustments for brain size in volumetric neuroimaging studies: Some practical implications in methods

Psychiatry Research - Neuroimaging

Volumn 193, Issue 2, 2011, Pages 113-122

  O'Brien, Liam M ^a   Ziegler, David A ^b   Deutsch, Curtis K ^c,d,e   Frazier, Jean A ^f   Herbert, Martha R ^c,g   Locascio, Joseph J ^b,c  

^a Colby College   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e MCLEAN HOSPITAL   (United States)

^f UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Morphometry; MRI; Regression models; Statistics

Indexed keywords

ANALYSIS OF COVARIANCE; ARTICLE; BODY SIZE; BRAIN SIZE; CEPHALOMETRY; CHILD; COMPARATIVE STUDY; CONCEPTUAL FRAMEWORK; DATA ANALYSIS; FEMALE; HUMAN; IMAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; MATHEMATICAL AND STATISTICAL PROCEDURES; METHODOLOGY; MORPHOMETRICS; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SCHOOL CHILD; STATISTICAL MODEL; STATISTICAL PARAMETERS; VOLUMETRY;

ADOLESCENT; BRAIN; BRAIN MAPPING; CHILD; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; ORGAN SIZE; STATISTICS AS TOPIC;

EID: 79959747111     PISSN: 09254927     EISSN: 18727506     Source Type: Journal    
DOI: 10.1016/j.pscychresns.2011.01.007     Document Type: Article

References (44)

1. Arndt S., Cohen G., Alliger R.J., Swayze V.W., Andreasen N.C. Problems with ratio and proportion measures of imaged cerebral structures. Psychiatry Research: Neuroimaging 1991, 40:79-89.
2. Bartholomeusz H.H., Courchesne E., Karns C.M. Relationship between head circumference and brain volume in healthy normal toddlers, children, and adults. Neuropediatrics 2002, 33:239-241.
3. Bolton P.F., Roobol M., Allsopp L., Pickles A. Association between idiopathic infantile macrocephaly and autism spectrum disorders. Lancet 2001, 358:726-727.
4. Buckner R.L., Head D., Parker J., Fotenos A.F., Marcus D., Morris J.C., Snyder A.Z. A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: reliability and validation against manual measurement of total intracranial volume. Neuroimage 2004, 23:724-738.
5. Bush E.C., Allman J.M. The scaling of white matter to gray matter in cerebellum and neocortex. Brain, Behavior and Evolution 2003, 61:1-5.
6. Caviness V.S., Meyer J., Makris N., Kennedy D.N. MRI-based topographic parcellation of human neocortex: an anatomically specified method with estimate reliability. Journal of Cognitive Neuroscience 1996, 8:566-587.
7. Changizi M.A. Principles underlying mammalian neocortical scaling. Biological Cybernetics 2001, 84:207-215.
8. Chen K.H.M., Chuah L.Y.M., Sim S.K.Y., Chee W.L. Hippocampal region-specific contributions to memory performance in normal elderly. Brain and Cognition 2010, 72:400-407.
9. Cheong J.L.Y., Hunt R.W., Anderson P.J., Howard K., Thompson D.K., Wang H.X., Bear M.J., Inder T.E., Dotle L.W. Head growth in preterm infants: correlation with magnetic resonance imaging and neurodevelopmental outcome. Pediatrics 2008, 121:E1534-E1540.
10. Cnaan A., Laird N.M., Slasor P. Using the general linear mixed model to analyse unbalanced repeated measures and longitudinal data. Statistics in Medicine 1997, 16:2349-2380.
11. Fidler D.J., Bailey J.N., Smalley S.L. Macrocephaly in autism and other pervasive developmental disorders. Developmental Medicine and Child Neurology 2000, 42:737-740.
12. Filipek P.A., Richelme C., Kennedy D.N., Caviness V.S. The young adult human brain: an MRI-based morphometric analysis. Cerebral Cortex 1994, 4:344-360.
13. Fombonne E., Roge B., Claverie J., Courty S., Fremolle J. Microcephaly and macrocephaly in autism. Journal of Autism and Developmental Disorders 1999, 29:113-119.
14. Frazier J.A., Breeze J.L., Makris N., Giuliano A.S., Herbert M.R., Seidman L., Biederman J., Hodge S.M., Dieterich M.E., Gerstein E., Kennedy D.N., Rauch S.L., Cohen B., Caviness V.S. Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorder. Bipolar Disorders 2005, 7:555-569.
15. Goldstein J.M., Goodman J.M., Seidman L.J., Kennedy D.N., Makris N., Lee H., Tourville J., Caviness V.S., Faraone S.V., Tsuang M.T. Cortical abnormalities in schizophrenia identified by structural magnetic resonance imaging. Archives of General Psychiatry 1999, 56:537-547.
16. Goldstein J.M., Seidman L.J., Makris N., Ahern T., O'Brien L.M., Caviness V.S., Kennedy D.N., Faraone S.V., Tsuang M.T. Hypothalamic abnormalities in schizophrenia: sex effects and genetic vulnerability. Biological Psychiatry 2007, 61:935-945.
17. Greenberg D.L., Messer D.F., Payne M.E., MacFall J.R., Provenzale J.M., Steffens D.C., Krishman R.R. Aging, gender, and the elderly adult brain: an examination of analytical strategies. Neurobiology of Aging 2008, 29:290-302.
18. Herbert M.R., Ziegler D.A., Deutsch C.K., O'Brien L.M., Lange N., Bakardjiev A., Hodgson J., Adrien K.T., Steele S., Makris N., Kennedy D., Harris G.J., Caviness V.S. Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys. Brain 2003, 126:1182-1192.
19. Herbert M.R., Zuegler D.A., Makris N., Filipek P.A., Kemper T.L., Normandin J.J., Sanders H.A., Kennedy D.N., Caviness V.S. Localization of white matter volume increase in autism and developmental language disorder. Annals of Neurology 2004, 55:530-540.
20. Kennedy D.N., Lange N., Makris N., Bates J., Meyer J., Caviness V.S. Gyri of the human neocortex: an MRI-based analysis of volume and variance. Cerebral Cortex 1998, 8:372-384.
21. Kutner M.H., Nachtsheim C.J., Neter J., Li W. Applied Linear Statistical Models 2005, 278-289. McGraw-Hill, New York.
22. Lainhart J.E., Piven J., Wzorek M., Landa R., Santangelo S.L., Coon H., Folstein S.E. Macrocephaly in children and adults with autism. Journal of the American Academy of Child and Adolescent Psychiatry 1997, 36:282-290.
23. Leonard C.M., Towler S., Welcome S., Halderman L.K., Otto R., Eckhart M.A., Chiarello C. Size matters: cerebral volume influences sex differences in neuroanatomy. Cerebral Cortex 2008, 18:2920-2931.
24. Locascio J.J., Cordray D.S. A reanalysis of Lord paradox. Educational and Psychological Measurement 1983, 43:115-126.
25. Makris N., Oscar-Berman M., Jaffin S.K., Hodge S.M., Kennedy D.N., Caviness V.S., Marinkovic K., Breiter H.C., Gasic G.P., Harris G.J. Biological Psychiatry 2008, 64:192-202.
26. Mathalon D.H., Sullivan E.V., Rawles J.M., Pfefferbaum A. Correction for head size in brain-imaging measurements. Psychiatry Research: Neuroimaging 1993, 50:121-139.
27. McCaffery P., Deutsch C.K. Macrocephaly and the control of brain growth in autistic disorders. Progress in Neurobiology 2005, 77:38-56.
28. Mormino E.C., Kluth J.T., Madison C.M., Rabinovici G.D., Baker S.L., Miller B.L., Koeppe R.A., Mathis C.A., Weiner M.W., Jagust W.J., Initiative Alzheimer's Disease Neuroimaging Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. Brain 2009, 132:1310-1323.
29. O'Brien L.M., Ziegler D.A., Deutsch C.K., Kennedy D.N., Goldstein J.M., Seidman L.J., Hodge S., Makris N., Caviness V., Frazier J.A., Herbert M.R. Adjusting whole brain and cranial size in volumetric brain studies: a review of common adjustment factors and statistical methods. Harvard Review of Psychiatry 2006, 14:141-151.
30. Peters M., Jancke L., Staiger J.F., Schlaug G., Huang Y., Steinmetz H. Unresolved problems in comparing brain sizes in Homo Sapiens. Brain and Cognition 1998, 37:254-285.
31. Rademacher J., Galaburda A.M., Kennedy D.N., Filipek P.A., Caviness V.S. Human cerebral cortex: localization, parcellation, and morphometry with magnetic resonance imaging. Journal of Cognitive Neuroscience 1992, 4:352-374.
32. Rauch S.L., Makris N., Cosgrove G.R., Kim H., Cassem E.H., Price B.H., Baer L., Savage C.R., Caviness V.S., Jenike M.A., Kennedy D.N. A magnetic resonance imaging study of regional cortical volumes following stereotactic anterior cingulotomy. CNS Spectrums 2001, 6:214-222.
33. Rice S.A., Bigler E.D., Cleavinger H.B., Tate D.F., Sayer J., McMahon W., Ozonoff S., Lu J., Lainhart J.E. Macrocephaly, corpus callosum morphology, and autism. Journal of Child Neurology 2005, 20:34-41.
34. Ridgway B.J., Henley S.M., Lehman M., Hobbs N., Clarkson M.J., Macmanus D.G., Ourselin S., Fox N.C. Head size, age, and gender adjustments in MRI studies: a necessary nuisance?. Neuroimage 2010, 53:1244-1255.
35. Seidman L.J., Faraone S.V., Goldstein J.M., Goodman J.M., Kremen W.S., Toomey R., Tourville J., Kennedy D., Makris N., Caviness V.S., Tsuang M.T. Thalamic and amygdala-hippocampal volume reductions in first-degree relatives of patients with schizophrenia: an MRI-based morphometric analysis. Biological Psychiatry 1999, 46:941-954.
36. Sullivan E.V. Compromised pontocerebellar and cerebellothalamocortical systems: speculations on their contributions to cognitive and motor impairment in nonammesic alcoholism. Alcocholism: Clinical and Experimental Research 2003, 27:1409-1419.
37. Sullivan E.V., Rosenbloom M.J., Desmond, J.E.S.V., Pfefferbaum A. Sex differences in corpus callosum size: relationship to age and intracranial size. Neurobiology of Aging 2001, 22:603-611.
38. Takayanagi Y., Kawasaki Y., Nakamura K., Takahasi T., Orikabe L., Toyoda E., Mozue Y., Sato Y., Itokawa M., Yamasue H., Kasai K., Kurachi M., Okazaki Y., Matsushita M., Suzuki M. Differentiation of first-episode schizophrenia patients from healthy controls using ROI-based multiple structural brain variables. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2010, 34:10-17.
39. Takeoka M., Riviello J.J., Duffy F.H., Kim F., Kennedy D.N., Makris N., Caviness V.S., Holmes G.L. Bilateral volume reduction of the superior temporal areas in Landau-Kleffner syndrome. Neurology 2004, 63:289-292.
40. Tobias R.D. Multiple Comparisons and Multiple Tests: Using the SAS System Workbook 2000, SAS Publishing, Cary, NC.
41. Ueda K., Fujiwara H., Miyata J., Hirao K., Saze T., Kawada R., Fujimoto S., Tanaka Y., Sawamoto N., Fukuyama H., Murai T. Investigating association of brain volumes with intracranial capacity in schizophrenia. Neuroimage 2010, 49:2503-2508.
42. Van Petten C. Relationship between hippocampal volume and memory ability in healthy individuals across the lifespan: review and meta-analysis. Neuropsychologia 2004, 42:1394-1413.
43. Vidal C.N., Nicholson R., Boire J.-Y., Barra V., DeVito T.J., Hayashi K.M., Geaga J.A., Drost D.J., Williamson P.C., Nagalingam R., Toga A.W., Thompson P.M. Three-dimensional mapping of the lateral ventricles in autism. Psychiatry Research: Neuroimaging 2008, 163:106-115.
44. Zhang K., Sejnowski T.J. A universal scaling law between gray matter and white matter of cerebral cortex. Proceedings of the National Academy of Sciences of the United States of America 2000, 97:5621-5626.