Human β-Defensin-2 Induction in Nasal Mucosa after Administration of Bacterial Lysates

Archives of Medical Research

Volumn 42, Issue 3, 2011, Pages 189-194

  Guaní Guerra, Eduardo ^a,b   Negrete García, María Cristina ^b   Montes Vizuet, Rosalía ^b   Asbun Bojalil, Juan ^a   Terán, Luis M ^b  

^a National Polytechnic Institute (ESM IPN)   (Mexico)

^b INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS   (Mexico)

Author keywords

Antimicrobial peptides; Bacterial lysates; Defensins; Host defense; Immunostimulants; Nasal mucosa

Indexed keywords

BACTERIUM LYSATE; BETA DEFENSIN 2; COLECALCIFEROL;

ADULT; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NASAL BIOPSY; NASAL LAVAGE; NONHUMAN; NORMAL HUMAN; NOSE MUCOSA; NOSE OBSTRUCTION;

ADOLESCENT; ADULT; BACTERIA; BETA-DEFENSINS; CELL EXTRACTS; CHOLECALCIFEROL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; FEMALE; HUMANS; IMMUNITY, INNATE; MALE; NASAL LAVAGE FLUID; NASAL MUCOSA; YOUNG ADULT;

EID: 79959742240     PISSN: 01884409     EISSN: 18735487     Source Type: Journal    
DOI: 10.1016/j.arcmed.2011.04.003     Document Type: Article

References (32)

1. Mason C.M., Nelson S. Pulmonary host defenses and factors predisposing to lung infection. Clin Chest Med 2005, 26:11-17.
2. Blouquit-Laye S., Chinet T. Ion and liquid transport across the bronchiolar epithelium. Respir Physiol Neurobiol 2007, 159:278-282.
3. Brandtzaeg P. Mucosal immunity: induction, dissemination, and effector functions. Scand J Immunol 2009, 70:505-515.
4. Bals R. Epithelial antimicrobial peptides in host defense against infection. Respir Res 2000, 1:141-150.
5. Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 2003, 3:710-720.
6. Schutte B.C., Mitros J.P., Bartlett J.A., et al. Discovery of five conserved beta-defensin gene clusters using a computational search strategy. Proc Natl Acad Sci USA 2002, 99:2129-2133.
7. Yang D., Biragyn A., Kwak L.W., et al. Mammalian defensins in immunity: more than just microbicidal. Trends Immunol 2002, 23:291-296.
8. Guaní-Guerra E., Santos-Mendoza T., Lugo-Reyes S.O., et al. Antimicrobial peptides: general overview and clinical implications in human health and disease. Clin Immunol 2010, 135:1-11.
9. Raj P.A., Dentino A.R. Current status of defensins and their role in innate and adaptive immunity. FEMS Microbiol Lett 2002, 206:9-18.
10. Lai Y., Gallo R.L. AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense. Trends Immunol 2009, 30:131-141.
11. Harder J., Meyer-Hoffert U., Teran L.M., et al. Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia. Am J Respir Cell Mol Biol 2000, 22:714-721.
12. Selleri S., Arnaboldi F., Palazzo M., et al. Toll-like receptor agonists regulate beta-defensin 2 release in hair follicle. Br J Dermatol 2007, 156:1172-1177.
13. Schaad U.B., Mütterlein R., Goffin H. BV-Child Study Group. Immunostimulation with OM-85 in children with recurrent infections of the upper respiratory tract: a double-blind, placebo-controlled multicenter study. Chest 2002, 122:2042-2049.
14. Steurer-Stey C., Lagler L., Straub D.A., et al. Oral purified bacterial extracts in acute respiratory tract infections in childhood: a systematic quantitative review. Eur J Pediatr 2007, 166:365-376.
15. Rozy A., Chorostowska-Wynimko J. Bacterial immunostimulants-mechanism of action and clinical application in respiratory diseases. Pneumonol Alergol Pol 2008, 76:353-359.
16. Keul R., Roth M., Papakonstantinou E., et al. Induction of interleukin 6 and interleukin 8 expression by Broncho-Vaxom (OM-85 BV) via C-Fos/serum responsive element. Thorax 1996, 51:150-154.
17. Roth M. Characterization of intracellular signal transduction and transcription factors involved in bronchovaxom (OM85BV) induced expression of interleukin-6 and interleukin 8 in human pulmonary fibroblast. Eur Respir Rev 1996, 6:171-175.
18. Broug-Holub E., Persoons J.H., Schornagel K., Kraal G. Changes in cytokine and nitric oxide secretion by rat and alveolar macrophages after oral administration of bacterial extracts. Clin Exp Immunol 1995, 101:302-307.
19. Mauel J., Van Pham T., Kreis B., Bauer J. Stimulation by a bacterial extract (Broncho Vaxom) of the metabolic and functional activities of murine macrophages. Int J Immunopharmacol 1989, 11:637-645.
20. Grünberg K., Timmers M.C., Smits H.H., et al. Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin-8 in nasal lavage in asthmatic subjects in vivo. Clin Exp Allergy 1997, 27:36-45.
21. Belda J., Parameswaran K., Keith P.K., et al. Repeatability and validity of cell and fluid-phase measurements in nasal fluid: a comparison of two methods of nasal lavage. Clin Exp Allergy 2001, 31:1111-1115.
22. Salzman N.H., Chou M.M., de Jong H., et al. Enteric salmonella infection inhibits Paneth cell antimicrobial peptide expression. Infect Immun 2003, 71:1109-1115.
23. Jacobsen F., Mittler D., Hirsch T., et al. Transient cutaneous adenoviral gene therapy with human host defense peptide hCAP-18/LL-37 is effective for the treatment of burn wound infections. Gene Ther 2005, 12:1494-1502.
24. Paupe J. Immunotherapy with an oral bacterial extract (OM-85 BV) for upper respiratory infections. Respiration 1991, 58:150-154.
25. Jara-Perez J.V., Berber A. Primary prevention of acute respiratory tract infections in children using a bacterial immunostimulant: a double-masked, placebo-controlled clinical trial. Clin Ther 2000, 22:748-759.
26. Gutierrez-Taraugo M.D., Berbe A. Safety and efficacy of two courses of OM-85 BV in the prevention of respiratory tract infections in children during 12 months. Chest 2001, 119:1742-1748.
27. Chen P.H., Fang S.Y. Expression of human beta-defensin 2 in human nasal mucosa. Eur Arch Otorhinolaryngol 2004, 261:238-241.
28. Vora P., Youdim A., Thomas L.S., et al. Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells. J Immunol 2004, 173:5398-5405.
29. Amlie-Lefond C., Paz D.A., Connelly M.P., et al. Innate immunity for biodefense: a strategy whose time has come. J Allergy Clin Immunol 2005, 116:1334-1342.
30. Sørensen O.E., Thapa D.R., Rosenthal A., et al. Differential regulation of beta-defensin expression in human skin by microbial stimuli. J Immunol 2005, 174:4870-4879.
31. Schauber J., Dorschner R.A., Yamasaki K., et al. Control of the innate epithelial antimicrobial response is cell-type specific and dependent on relevant microenvironmental stimuli. Immunology 2006, 118:509-519.
32. Wang T.T., Nestel F.P., Bourdeau V., et al. Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol 2004, 173:2909-2912.