Pharmacokinetics of intravenous amiodarone and its electrocardiographic effects on healthy Japanese subjects

Heart and Vessels

Volumn 26, Issue 3, 2011, Pages 274-281

  Shiga, Tsuyoshi ^a   Tanaka, Takanori ^b   Irie, Shin ^b   Hagiwara, Nobuhisa ^a   Kasanuki, Hiroshi ^a,c  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b Medical Co LTA Clinical Pharmacology Center   (Japan)

^c WASEDA UNIVERSITY   (Japan)

Author keywords

Amiodarone; Desethylamiodarone; Healthy subjects; Pharmacokinetics

Indexed keywords

AMIODARONE; DEETHYLAMIODARONE; GLUCOSE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BRADYCARDIA; CONTINUOUS INFUSION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISTRIBUTION VOLUME; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE COMPARISON; DRUG DOSE ESCALATION; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; ELECTROCARDIOGRAM; HOLTER MONITORING; HUMAN; HUMAN EXPERIMENT; HYPOTENSION; INJECTION SITE PAIN; JAPANESE; KERATOSCOPY; LABORATORY TEST; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NORMAL HUMAN; PAIN; PHASE 1 CLINICAL TRIAL; PHYSICAL EXAMINATION; PR INTERVAL; PRIORITY JOURNAL; PULSE RATE; QRS COMPLEX; QTC INTERVAL; RANDOMIZED CONTROLLED TRIAL; RR INTERVAL; SINGLE DRUG DOSE; STEADY STATE; SUPINE POSITION; SYSTOLIC BLOOD PRESSURE; THORAX RADIOGRAPHY; THYROID FUNCTION TEST; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADULT; AMIODARONE; ANTI-ARRHYTHMIA AGENTS; AREA UNDER CURVE; ASIAN CONTINENTAL ANCESTRY GROUP; BIOTRANSFORMATION; BLOOD PRESSURE; COMPUTER SIMULATION; ELECTROCARDIOGRAPHY, AMBULATORY; HALF-LIFE; HEART RATE; HUMANS; INFUSIONS, INTRAVENOUS; JAPAN; MALE; MODELS, BIOLOGICAL; YOUNG ADULT;

EID: 79959740837     PISSN: 09108327     EISSN: 16152573     Source Type: Journal    
DOI: 10.1007/s00380-010-0047-7     Document Type: Article

References (20)

1. Podrid PJ (1995) Amiodarone: reevaluation of an old drug. Ann Intern Med 122:689-700
2. Shiga T, Wakaumi M, Imai T, Suzuki T, Hosaka F, Yamada Y, Matsuda N, Shoda M, Sugiura R, Hagiwara N, Kasanuki H (2002) Effect of low-dose amiodarone on atrial fibrillation or flutter in Japanese patients with heart failure. Circ J 66:600-604 (Pubitemid 34733504)
3. Shiga T, Wakaumi M, Matsuda N, Shoda M, Hagiwara N, Sato K, Kasanuki H (2001) Amiodarone-induced thyroid dysfunction and ventricular tachyarrhythmias during long-term therapy in Japan. Jpn Circ J 65:958-960
4. Yamada Y, Shiga T, Matsuda N, Hagiwara N, Kasanuki H (2007) Incidence and predictors of pulmonary toxicity in Japanese patients receiving low-dose amiodarone. Circ J 71:1610-1616 (Pubitemid 47529665)
5. Suzuki S, Yamashita T, Otsuka T, Sagara K, Uejima T, Oikawa Y, Yajima J, Koike A, Nagashima K, Kirigaya H, Ogasawara K, Sawada H, Yamazaki T, Aizawa T (2009) Treatment strategy and clinical outcomes in Japanese patients with atrial fibrillation. Heart Vessels 24:287-293
6. Takahashi A, Shiga T, Shoda M, Tanizaki K, Manaka T, Ejima K, Kasanuki H, Hagiwara N (2010) Gender difference in arrhythmic occurrences in patients with nonischemic dilated cardiomyopathy and implantable cardioverter-defibrillator. Heart Vessels 25:150-154
7. Chow MS (1996) Intravenous amiodarone: pharmacology, pharmacokinetics, and clinical use. Ann Pharmacother 30:637-643
8. Vadiei K, Troy S, Korth-Bradley J, Chiang ST, Zimmerman JJ (1997) Population pharmacokinetics of intravenous amiodarone and comparison with two-stage pharmacokinetic analysis. J Clin Pharmacol 37:610-617 (Pubitemid 27443542)
9. Roden DM (1993) Pharmacokinetics of amiodarone: implications for drug therapy. Am J Cardiol 72:45F-50F
10. Vadiei K, O'Rangers EA, Klamerus KJ, Kluger J, Kazierad DJ, Leese PT, Chow MS, Zimmerman JJ (1996) Pharmacokinetics of intravenous amiodarone in patients with impaired left ventricular function. J Clin Pharmacol 36:720-727 (Pubitemid 26295776)
11. Kamiya K, Nishiyama A, Yasui K, Hojo M, Sanguinetti MC, Kodama I (2001) Short- and long-term effects of amiodarone on the two components of cardiac delayed rectifier K(+) current. Circulation 103:1317-1324 (Pubitemid 32221358)
12. Kodama I, Kamiya K, Toyama J (1999) Amiodarone: ionic and cellular mechanisms of action of the most promising class III agent. Am J Cardiol 84:20R-28R
13. Ikeda N, Nademanee K, Kannan R, Singh BN (1984) Electrophysiologic effects of amiodarone: experimental and clinical observation relative to serum and tissue concentrations. Am Heart J 108:890-898 (Pubitemid 14015515)
14. Desai AD, Chun S, Sung RJ (1997) The role of intravenous amiodarone in the management of cardiac arrhythmias. Ann Intern Med 127:294-303 (Pubitemid 27352051)
15. Morady F, DiCarlo LA Jr, Krol RB, Baerman JM, de Buitleir M (1986) Acute and chronic effects of amiodarone on ventricular refractoriness, intraventricular conduction and ventricular tachycardia induction. J Am Coll Cardiol 7:148-157 (Pubitemid 16132469)
16. Cinelli P, Romano S, Castaldo G, de Scalzi M, Citi S, de Leonardis V (1984) Computerized M-mode echocardiography in the assessment of cardiovascular effects during intravenous administration of amiodarone. Methods Find Exp Clin Pharamcol 6:27-32 (Pubitemid 14135222)
17. Munoz A, Karila P, Gallay P, Zettelmeier F, Messner P, Mery M, Grolleau R (1988) A randomized hemodynamic comparison of intravenous amiodarone with and without Tween 80. Eur Heart J 9:142-148
18. Remme WJ, Kruyssen HA, Look MP, van Hoogenhuyze DC, Krauss XH (1991) Hemodynamic effects and tolerability of intravenous amiodarone in patients with impaired left ventricular function. Am Heart J 122(1 Pt 1):96-103
19. Cushing DJ, Adams MP, Cooper WD, Zhang B, Lipicky RJ, Kowey PR (2009) Evaluation of the effects of PM101, a cyclodextrin-based formulation of intravenous amiodarone, on blood pressure in healthy humans. Am J Cardiol 104:1152-1157
20. Kowey PR, Marinchak RA, Rials SJ, Filart RA (1997) Intravenous amiodarone. J Am Coll Cardiol 29:1190-1198 (Pubitemid 27201934)