Differential expression of DUSP6 with expression of ERK and Ki-67 in non-small cell lung carcinoma

Pathology Research and Practice

Volumn 207, Issue 7, 2011, Pages 428-432

  Lee, Hyunjung ^a   Kim, Jin Man ^a   Huang, Song Mei ^a   Park, Seung Kiel ^a   Kim, Dong Hoon ^b   Kim, Do Hyung ^c   Lee, Choong Sik ^a   Suh, Kwang Sun ^a   Yi, Eunhee S ^d   Kim, Kyung Hee ^a  

^a Chungnam National University   (South Korea)

^b Sungkyunkwan University School of Medicine   (South Korea)

^c Eulji University   (South Korea)

^d MAYO CLINIC   (United States)

Author keywords

Adenocarcinoma; Dual specificity phosphatase 6; Extracellular signal regulated kinase; Lung; Squamous cell carcinoma

Indexed keywords

DUAL SPECIFICITY PHOSPHATASE 6; KI 67 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE;

ANALYTICAL PARAMETERS; ARTICLE; CANCER GROWTH; CANCER RESISTANCE; CORRELATION ANALYSIS; CPG ISLAND; DISEASE ASSOCIATION; DNA METHYLATION; DNA SEQUENCE; DOWN REGULATION; HETEROZYGOSITY; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; NEGATIVE FEEDBACK; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SQUAMOUS CELL CARCINOMA;

ADENOCARCINOMA; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; DNA, NEOPLASM; DUAL SPECIFICITY PHOSPHATASE 6; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; KI-67 ANTIGEN; LUNG NEOPLASMS; PNEUMONECTOMY; TUMOR MARKERS, BIOLOGICAL;

EID: 79959727255     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2011.05.004     Document Type: Article

References (17)

1. Furukawa T., Yatsuoka T., Youssef E.M., et al. Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer. Cytogenet. Cell Genet. 1998, 82:156-159.
2. Peyssonnaux C., Eychene A. The Raf/MEK/ERK pathway: new concepts of activation. Biol. Cell 2001, 93:53-62.
3. Bermudez O., Pages G., Gimond C. The dual-specificity MAP kinase phosphatases: critical roles in development and cancer. Am. J. Physiol. Cell Physiol. 2010, 299:C189-202.
4. Keyse S.M. Dual-specificity MAP kinase phosphatases (MKPs) and cancer. Cancer Metastasis Rev. 2008, 27:253-261.
5. Chiappinelli K.B., Rimel B.J., Massad L.S., Goodfellow P.J. Infrequent methylation of the DUSP6 phosphatase in endometrial cancer. Gynecol. Oncol. 2010, 119:146-150.
6. Zhang Z.F., Kobayashi S., Borczuk A.C., et al. Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells. Carcinogenesis 2010, 31:577-586.
7. Ekerot M., Stavridis M.P., Delavaine L., et al. Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter. Biochem. J. 2008, 412:287-298.
8. Furukawa T., Tanji E., Xu S., Horii A. Feedback regulation of DUSP6 transcription responding to MAPK1 via ETS2 in human cells. Biochem. Biophys. Res. Commun. 2008, 377:317-320.
9. Jurek A., Amagasaki K., Gembarska A., Heldin C.H., Lennartsson J. Negative and positive regulation of MAPK phosphatase 3 controls platelet-derived growth factor-induced Erk activation. J. Biol. Chem. 2009, 284:4626-4634.
10. Furukawa T., Sunamura M., Motoi F., Matsuno S., Horii A. Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer. Am. J. Pathol. 2003, 162:1807-1815.
11. Xu S.H., Furukawa T., Kanai N., Sunamura M., Horii A. Abrogation of DUSP6 by hypermethylation in human pancreatic cancer. J. Hum. Genet. 2005, 50:159-167.
12. Okudela K., Yazawa T., Woo T., et al. Down-regulation of DUSP6 expression in lung cancer: its mechanism and potential role in carcinogenesis. Am. J. Pathol. 2009, 175:867-881.
13. Greene F.L.P.D., Fleming I.D., et al. AJCC Cancer Staging Manual 2002, Springer-Verlag, New York, NY. 6th ed.
14. Sica G., Yoshizawa A., Sima C.S., et al. A grading system of lung adenocarcinomas based on histologic pattern is predictive of disease recurrence in stage I tumors. Am. J. Surg. Pathol. 2010, 34:1155-1162.
15. Allred D.C., Harvey J.M., Berardo M., Clark G.M. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod. Pathol. 1998, 11:155-168.
16. Xu S., Furukawa T., Kanai N., Sunamura M., Horii A. Abrogation of DUSP6 by hypermethylation in human pancreatic cancer. J. Hum. Genet. 2005, 50:159-167.
17. Nyunoya T., Monick M.M., Powers L.S., Yarovinsky T.O., Hunninghake G.W. Macrophages survive hyperoxia via prolonged ERK activation due to phosphatase down-regulation. J. Biol. Chem. 2005, 280:26295-26302.